Copper‐based Metal‐organic Framework for Non‐enzymatic Electrochemical Detection of Glucose

Abstract

A non-enzymatic electrochemical glucose sensor based on a Cu-based metal-organic framework (Cu-MOF) modified electrode was developed. The Cu-MOF was prepared by a simple ionothermal synthesis, and the characterizations of the Cu-MOF were studied by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), single-crystal X-ray powder diffraction (SCXRD), and X-ray powder diffraction (XRD). Electrochemical behaviors of the Cu-MOF modified electrode to glucose were measured by differential pulse voltammetry (DPV). The electrochemical results showed that the Cu-MOF modified electrode exhibited an excellent electro-catalytic oxidation towards glucose in the range of 0.06 mM to 5 mM with a sensitivity of 89 mA/mM cm 2 and a detection limit of 10.5 nM. Moreover, the fabricated sensor showed a high selectivity to the oxidation of glucose in coexistence with other interferences. The sensor was satisfactorily applied to the determination of glucose in urine samples. With the significant electrochemical performances, MOFs may provide a suitable platform in the construction of kinds of electrochemical sensors and/or biosensors and hold a great promise for sensing applications.

Highly Oriented Nitrogen‐doped Carbon Nanotube Integrated Bimetallic Cobalt Copper Organic Framework for Non‐enzymatic Electrochemical Glucose and Hydrogen Peroxide Sensor

“…Similarly, the electrooxidation mechanism of glucose in copper nanoparticles consists of the following steps:[23, 45] …”

Electrochemically Activated Conductive Ni-Based MOFs for Non-enzymatic Sensors Toward Long-Term Glucose Monitoring

“…The effects of scan rate were tested in the range of 10-100 mV s −1 in the presence of 2 mM glucose in 0.1 M KOH (Figure 5). (Sun et al, 2018) Ni-BTC CV 0.55 5-3000; 3500-6000 - (Chen et al, 2020) Ni-BDC CV 0.63 10-800 - (Gumilar et al, 2020) Ni/Co-TCPP CV 0.40 1.0-3800 - (Li et al, 2020a) NiO/Cu-TCPP CV 0.50 3-300 - (Li et al, 2020a) NiCo-MOFs nanosheets CV 0.50 1-8000 - (Li et al, 2019) Ag/Co-MOFs CV 0.55 5-550 30 times (Liu et al, 2019) Ni HITP,2,3,6,7,10, The anodic peak current was proportional to the square root of the scan rate (v 1/2 ), linearly following the linear regression equation:…”

“…They have been applied in various fields including gas sorption and separation, catalysis, sensors, cancer therapy, and drug delivery (Li et al, 2009;Lu et al, 2018;Zhou et al, 2018;Liang et al, 2019;Rojas et al, 2019;Wang et al, 2020). For electrochemical glucose sensors, Cu-MOFs, Co-MOFs, Ni-MOFs, and their metal oxide composites have been developed (Sun et al, 2018;Li et al, 2020b;Liu et al, 2020;Qiao et al, 2020;Shahrokhian et al, 2020). Conductive Ni 3 (2,3,6,7,10,11-hexaiminotriphenylene) 2 (2,3,6,7,10,11-hexaiminotriphenylene=HITP) MOFs exhibit very high electrical conductivity, exceeding those of previous semiconducting metal-organic graphene analogs and other conductive MOFs, which are even higher than some of the best organic conductors (Sheberla et al, 2014).…”

MOF‐Derived Spinel NiCo2O4 Hollow Nanocages for the Construction of Non‐enzymatic Electrochemical Glucose Sensor

“…It is worth mentioning that MOFs and their derivatives exhibit multiple functions in the field of glucose sensing. MOFs and their derivatives can be used not only as enzyme immobilization platforms for enzymatic sensors [39,40], but also as electrocatalysts for enzyme-independent sensors [22,41].…”