Copper-catalyzed steroid reactions

Abstract

We review the most important achievements of the last decade in the field of steroid synthesis in the presence of copper catalysts. This method shows great promise to allow the development of novel molecules with different functions using copper as catalyst. New functional steroidsCu catalyst steroid

Studies on the Chemical Transformations of 6‐Methylchromone‐3‐carbonitrile under Nucleophilic Conditions

“…Also, reaction of carbonitrile 1 with N ′‐[(4‐methoxyphenyl)methylidene]‐2‐cyanoacetohydrazide ( 5 ) in boiling ethanol containing few drops of DBU yielded the unexpected 2‐amino‐5‐cyano‐ N ′‐[(4‐methoxyphenyl)methylidene]‐8‐methyl‐6‐oxo‐6 H ‐1‐benzoxocine‐3‐carbohydrazide ( 6 ) . The expected product from the latter reaction, 2‐amino‐ N ′‐[(4‐methoxyphenyl)methylidene]‐7‐methyl‐5‐oxo‐5 H ‐chromeno [2,3‐ b ]pyridine‐3‐carbohydrazide ( 7 ), via intermediate F , was excluded based on the spectral data (Scheme ).…”

Steroidal lactams: a review

“…Even after decades of research, the total synthesis of steroid nuclei by improved strategies continues to receive considerable attention. Numerous methods [28][29][30][31][32][33][34] have been exploited for the total synthesis of steroids which are widely distributed in nature, and which possess practical medical importance. Research into steroid total synthesis continues to this day.…”

A short review on selena and tellurasteroids

“…Research into steroid total synthesis continues to this day. [28][29][30][31] The fact that the introduction of a heteroatom in steroid structures can cause extensive changes in biological activity has long intrigued medicinal chemists. Naturally occurring steroid nuclei have been modified in several ways to recognize the structural and stereochemical features required for the display of specific, selective physiological activity and for finding more active compounds, free from undesirable or harmful side effects.…”