Copper Dissolution and Hydrogen Peroxide Formation in Aqueous Media

Olszowka, S. A.; Manning, M. A.; Barkatt, Aaron

doi:10.5006/1.3315954

Cited by 20 publications

(11 citation statements)

References 2 publications

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“…57,58 It has been demonstrated that Cu NP dissolution produces hydrogen peroxide and ROS as a byproduct of the process. 38 In comparison, the dissolution of CuO NPs does not generate ROS, though intracellular ROS have been detected in other studies. 59 Previously, we demonstrated that the likely mechanistic cause of the different toxicity between Cu NP and CuO NP in embryonic zebrafish was due to the ability of each NP generating ROS.…”

Section: Discussionmentioning

confidence: 81%

“…[35][36][37] The dissolution of metallic Cu generates ROS, while similar ROS generation from the dissolution of CuO is unclear. 38,39 In addition, Cu NPs can form a thin oxidized surface layer when exposed to an oxygenated ambient environment, transforming the surface reactivity and adsorption properties of the particle. 40 Additionally, Cu and CuO NPs may also have different aggregation tendencies (even if primary particle size is held constant) due to the difference in their surface interactions with each other and the surrounding environment.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Cu and CuO nanoparticle ecological responses using laboratory small-scale microcosms

Harper

Crandon

et al. 2020

Environ. Sci.: Nano

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Assessment of Cu and CuO nanoparticle ecological responses using laboratory small-scale microcosms

Harper

Crandon

et al. 2020

Environ. Sci.: Nano

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“…40 In the presence of oxygen, Cu NPs can form superoxide and hydrogen peroxide in addition to releasing Cu ions. 21,41 These reactions do not occur to the same extent with CuO NPs, as CuO dissolution proceeds by hydrolysis to form various Cu hydroxyl complexes. 42 Based on this finding, we propose that it is the ability of Cu NPs to generate ROS, rather than their dissolution or another nano-specific mechanism, that makes them more toxic than CuO NPs.…”

Section: Discussionmentioning

confidence: 99%

“…16,19,20 One key difference between Cu and CuO is that the dissolution of metallic Cu can generate reactive oxygen species (ROS), while the dissolution of CuO does not. 20,21 ROS is known to contribute to the toxicity of many nanomaterials, but the release of ions and their resulting toxicity can make it difficult to differentiate which mechanism is dominating.…”

Section: Introductionmentioning

confidence: 99%

Reactive oxygen species generation is likely a driver of copper based nanomaterial toxicity

Denluck

Crandon

et al. 2018

Environ. Sci.: Nano

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Determining the specific nanomaterial features that elicit adverse biological responses is important to inform risk assessments, develop targeted applications, and rationally design future nanomaterials. Embryonic zebrafish are often employed to study nanomaterial-biological interactions, but few studies address the role of the chorion in nanomaterial exposure and toxicity. Here, we used chorion-intact (CI) or dechorionated (DC) embryonic zebrafish to investigate the influence of the chorion on copper-based nanoparticle toxicity. We found that despite higher dissolution and uptake, CuO NPs were less toxic than Cu NPs regardless of chorion status and did not cause 100 % mortality at even the highest exposure concentration. The presence of the chorion inhibited Cu toxicity: DC exposures to Cu NPs had an LC50 of 2.5 ± 0.3 mg/L compared to a CI LC50 of 13.7 ± 0.8 mg/L. This highlights the importance of considering zebrafish chorion status during nanotoxicological investigations, as embryo sensitivity increased by one order of magnitude or more when chorions were removed. Agglomerate size, zeta potential, and dissolved Cu did not sufficiently explain the differences in toxicity between Cu NPs and CuO NPs; however, reactive oxygen species (ROS) generation did. Cu NPs generated ROS in a concentration-dependent manner, while CuO did not and generated less than Cu NPs. We believe that the differences between the toxicities of Cu NPs and CuO NPs are due in part to their ability to generate ROS which could and should be a hazard consideration for risk assessments.

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“…3a. Subsequently, the formed Cu(OH) 2 reacted with H 2 O 2 to form intermediates such as Cu þ , CuO 2 , and CuOH; the intermediates are unstable and tend to revert gradually to Cu(OH) 2 [19]. This phenomenon leads to Cu(OH) 2 recrystallization during H 2 O 2 oxidation (Fig.…”

Section: Resultsmentioning

confidence: 92%