Copper(II) and manganese(III) complexes of N′-[(2-hydroxy phenyl) carbonothioyl] pyridine-2-carbohydrazide: novel therapeutic agents for cancer

Shrivastav, Anuraag; Singh, Nand K.; Tripathi, Pratibha; George, Theresa; Dimmock, Jonathan R.; Sharma, Rajendra K.

doi:10.1016/j.biochi.2006.03.004

Cited by 36 publications

(11 citation statements)

References 46 publications

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“…Our results suggest that another aspect of the NIP71/hsc70 overexpression could be to regulate elevated NMT activity in tumor cells. It has recently been shown that the knock down of NMT results in apoptosis (31,32). Our results suggest a novel relationship of NIP71/hsc70 and NMT and assign an important function of NIP71/hsc70 to regulate NMT activity in OSCC.…”

Section: Resultssupporting

confidence: 54%

Elevated N-myristoyltransferase activity and expression in oral squamous cell carcinoma

Shrivastav

Sharma²,

Bajaj³

et al. 2007

Oncol Rep

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Abstract. N-myristoyltransferase (NMT) catalyzes the myristoylation of proteins involved in signal transduction, cellular transformation, differentiation, proliferation and oncogenesis. In this study, we report for the first time on the elevated NMT activity in oral squamous cell carcinoma (OSCC). Increased activity is marked with increased staining for NMT in the OSCC samples compared to the normal adjacent tissues. In addition, we observed increased staining for the N-myristoyltransferase inhibitor protein 71 (NIP71) in the OSCC samples compared to the control tissues. These findings suggest the regulatory relationship between NMT and NIP71 during tumorigenesis. It is possible that the increased activity results in the overexpression of NIP71 in an effort to control NMT activity.

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Section: Resultssupporting

confidence: 54%

Elevated N-myristoyltransferase activity and expression in oral squamous cell carcinoma

Shrivastav

Sharma²,

Bajaj³

et al. 2007

Oncol Rep

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“…The aromatic protons were observed in the range of 7.23-8.72 ppm. Assignment of the 13 C NMR spectral data of the ligands is based on 13 C shifts in similar hydrazone ligands [38,40]. The signals observed at 163.72 and 153.66 ppm in H 2 L 1 ligand and 156.7 and 151.62 ppm in H 2 L 2 ligand can be assigned to C=O and C=N, respectively.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

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Two pentadentate carbohydrazone ligands, H 2 L 1 and H 2 L 2 , were prepared by the reaction of the bifunctional compound carbohydrazide with 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde, respectively. Reactions of the ligands with oxovanadium(IV), cerium(III), thorium(IV), and dioxouranium(VI) ions yielded binary complexes. Reactions of the ligands with the dioxouranium(VI) ion in the presence of secondary ligands (8-hydroxyquinoline, glycine, salicylaldehyde, or benzoylacetone) yielded ternary complexes. The ligands and metal complexes were characterized by different techniques such as elemental and thermal analyses, IR, 1 H and 13 C NMR, electronic, ESR, mass spectra, and powder XRD as well as magnetic susceptibility and conductivity measurements. The coordinating sites are phenolic oxygen, azomethine nitrogen, and carbonyl oxygen. In complexes, the ligands act as dibasic pentadentate except ternary dioxouranium(VI) complexes, obtained using glycine or benzoylacetone, in which the ligands act as monobasic pentadentate. The XRD patterns for the H 2 L 1 ligand, its binary dioxouranium(VI) complex, and its 8-hydroxyquinoline ternary complex indicate crystalline nature and the grain size was estimated. The H 2 L 1 ligand and its binary complex have triclinic systems while the ternary complex has a monoclinic system with different unit-cell parameters. The ligands and some of their metal complexes showed antimicrobial activity toward some Gram-positive and Gram-negative bacteria, yeast (Candida albicans), and fungus (Aspergillus fumigatus), and MIC values were determined. The DNA binding properties of the oxovanadium(IV) complexes of H 2 L 1 and H 2 L 2 ligands were investigated by electronic absorption spectroscopy and viscosity measurements. The results indicated that these complexes bind to DNA via an intercalation binding mode with an intrinsic binding constant K b of 2.55 9 10 4 and 3 9 10 4 M -1 , respectively.

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“…Four human alimentary system carcinoma cell lines, SGC7901 (gastric tumor cell line), EC109 (esophagus tumor cell line), SMMC7721 (liver tumor cell line), and HT29 (colon tumor cell line), were utilized in our work. These cell lines were chosen to explore the potential selectivity of our copper(II) complexes towards different human alimentary system carcinoma cell lines and all have been previously used in studies with copper complexes that are cytotoxic [18][19][20][21]. IC 50 values indicated that 2 and 3 have promising cytotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity towards human alimentary system carcinoma cells resulting from diverse copper(II) complexes

Zhao

Peng

Guo

et al. 2014

Journal of Coordination Chemistry

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To investigate the potential cytotoxicity of copper(II)-based complexes, three coordination compounds with heterocyclic ligands, Cu(pbmbt)Cl 2 (CH 3 OH) (1), Cu 2 (ddbib) 2 (NO 3 ) 4 ·3CH 3 OH (2), and Cu 3 (ttmtmb) 2 Cl 6 ·2.5H 2 O (3), which include mononuclear, dinuclear, and trinuclear structures, have been synthesized from reactions of corresponding copper(II) salts with 1-imidazole (ddbib), and 1,1′,1′′-((2,4,6-trimethylbenzene-1,3,5-triyl)tris(methylene)tris(2-methyl-1H-benzoimidazole) (ttmtmb), respectively. IC 50 values revealed that 2 and 3 show strong cytotoxicity, whereas 1 is weakly cytotoxic after being tested against a panel of several human alimentary system carcinoma cell lines (SGC7901, EC109, SMMC7721, and HT29). The number of copper centers and different structures could make a tremendous difference on their cytotoxicity. Three coordination compounds with heterocyclic ligands were constructed to investigate the potential cytotoxicity of copper(II)-based complexes. IC 50 values revealed that complexes 2 and 3 show strong cytotoxicity, whereas complex 1 is weakly cytotoxic after being tested by MTT assay against a panel of several human alimentary system carcinoma cell lines.

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Copper(II) and manganese(III) complexes of N′-[(2-hydroxy phenyl) carbonothioyl] pyridine-2-carbohydrazide: novel therapeutic agents for cancer

Cited by 36 publications

References 46 publications

Elevated N-myristoyltransferase activity and expression in oral squamous cell carcinoma

Elevated N-myristoyltransferase activity and expression in oral squamous cell carcinoma

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Cytotoxicity towards human alimentary system carcinoma cells resulting from diverse copper(II) complexes

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