Copper/Zinc Ratio Can Be a Marker to Diagnose Ectopic Pregnancy and Is Associated with the Oxidative Stress Status of Ectopic Pregnancy Cases

Tok, Abdullah; Özer, Alev; Baylan, Filiz Alkan; Kurutas, Ergul

doi:10.1007/s12011-020-02327-0

Cited by 13 publications

(6 citation statements)

References 39 publications

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“…Gao et al found a positive correlation between plasma Zn content and GPx activity and a negative correlation between plasma Zn content and MDA content [ 51 ]. However, other authors negatively related serum Zn to GPx and positively to SOD and found no significant relationship with CAT and MDA content, whereas serum Cu content positively relates to GPx and negatively relates to SOD and CAT; no significant relationship with MDA was found [ 52 ]. It has been described how Zn supplementation increases SOD activity but has no effect on GPx activity [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Sánchez-González

Moreno

Aranda

et al. 2022

Biology

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Our aim was to examine whether vanadium (IV) corrects alterations in zinc, copper and manganese homeostasis, observed in streptozotocin-induced hyperglycemic rats, and whether such changes are related to divalent metal transporter 1 (DMT1) mRNA expression, and antioxidant and proinflammatory parameters. Four groups of Wistar rats were examined: control; hyperglycemic (H); hyperglycemic treated with 1 mg V/day (HV); and hyperglycemic treated with 3 mg V/day (HVH). Vanadium was supplied in drinking water as bis(maltolato)oxovanadium(IV) for five weeks. Zinc, copper and manganese were measured in food, excreta, serum and tissues. DMT1 mRNA expression was quantified in the liver. Hyperglycemic rats showed increased Zn and Cu absorption and content in the liver, serum, kidneys and femurs; DMT1 expression also increased (p < 0.05 in all cases). HV rats showed no changes compared to H rats other than decreased DMT1 expression (p < 0.05). In the HVH group, decreased absorption and tissular content of studied elements (p < 0.05 in all cases) and DMT1 expression compared to H (p < 0.05) were observed. Liver zinc, copper and manganese content correlated positively with glutathione peroxidase activity and negatively with catalase activity (p < 0.05 in both cases). In conclusion, treatment with 3 mg V/d reverted the alterations in zinc and copper homeostasis caused by hyperglycemia, possibly facilitated by decreased DMT1 expression.

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Section: Discussionmentioning

confidence: 99%

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Sánchez-González

Moreno

Aranda

et al. 2022

Biology

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“…The Cu/Zn ratio is considered a clinically useful index compared to the concentration of Cu or Zn alone [ 17 ]. The Cu/Zn ratio has been reported to be a useful diagnostic marker for ectopic pregnancy related to oxidative stress in humans [ 18 ]. Uterine torsion induces significant oxidative stress at the tissue level due to the increased production of free radicals, as indicated by the high levels of malondialdehyde, superoxide dismutase, and glutathione [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Trace element concentrations in blood samples from dairy cows with uterine torsion and their neonatal calves

Kazama,

Sugita,

Onda

2023

Vet World

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Background and Aim: Mineral deficiencies can lead to dystocia and abnormalities in neonates. Stillbirth of neonatal calves in dairy cows due to dystocia has become an economic problem. Uterine torsion (UT) is a common form of dystocia observed in dairy cows. However, to the best of our knowledge, there have been no reports on the characteristics of serum trace element concentrations in dairy cows with UT. This study aimed to comprehensively measure serum trace element concentrations in dairy cows with UT and dystocia. Materials and Methods: Dairy cows with (n = 15) and without (n = 27) UT and neonates (n = 9 and n = 26, respectively) were included in this study. Blood samples (10 mL) were collected, and serum trace element concentrations were evaluated using inductively coupled plasma mass spectrophotometry. Results: The mortality rate at birth was significantly higher in calves delivered by cows with UT than those delivered by cows without UT. The odds ratio for mortality rate at birth in dairy cows with UT was 7.85. Serum zinc (Zn) levels were significantly lower in cows with UT than in cows without UT (p = 0.01). The copper: Zn ratio was significantly higher in cows with UT than in cows without torsion (p = 0.05). In contrast, serum Cobalt (Co) concentrations were significantly higher in neonates from cows with UT than in neonates from cows without UT (p = 0.01). Conclusion: Uterine torsion is associated with a high mortality rate at birth and considerable economic losses. Cows with UT had low serum Zn levels, and neonates born to these cows had high serum Co levels. Keywords: cattle, dystocia, mortality calves, neonate, trace elements.

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“…In the present study, reduced GSH content and GPx activity and increased MDA level in TP indicated changes in the balance of the oxidant–antioxidant system, which impaired mitochondrial activity and ciliary motility in the tubal epithelium. 3 …”

Section: Discussionmentioning

confidence: 99%

“… 2 An imbalance between oxidant and antioxidant processes may alter the tubal environment and reduce tubal ciliary pulsation and smooth-muscle contractions which, in turn, increase the risk of TP by disrupting transport mechanisms in the embryo. 3 However, few studies have focused on lipid peroxidation in TP.…”

Section: Introductionmentioning

confidence: 99%

Shikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity

Lai¹,

Zeng²,

Chen³

et al. 2022

DDDT

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Background Albeit oxidative stress has been implied in the pathogenesis of tubal pregnancy (TP), there are scant data to suggest that ferroptosis occurs in TP. Shikonin plays a pivotal role in redox status, but whether it can regulate ferroptosis to treat TP remains unknown. Methods We collected and analyzed ferroptosis-related indices from the villous tissue (VT) of women suffering from TP and from women with a normal pregnancy. In vitro, we used shikonin and/or RAS-selective lethal 3 (RSL3) to intervene HTR-8/SVneo cells and further detected ferroptosis indices and cell functions. Finally, the expression of the nuclear factor erythroid 2-related factor 2 (Nrf2) is pharmacologically activated to explore the effect of Nrf2 on shikonin regulating ferroptosis. Results Increased malondialdehyde content, reduced levels of glutathione and glutathione peroxidase (GPx), and upregulated protein expression which promoted ferroptosis were observed in the VT of TP patients, suggesting that ferroptosis occurred during TP. In vitro, shikonin enhanced ferroptosis sensitivity in HTR-8/SVneo cells induced by RSL3 via amplifying lipid peroxidation, which mainly included increasing cellular reactive oxygen species (ROS), lipid ROS and Fe 2+ level. RSL3 and/or shikonin inhibited Nrf2 and downregulated protein expression of SLC7A11 and GPx4 caused by RSL3 + shikonin co-treatment, which could be reversed under activation of Nrf2. Hence, shikonin facilitated lipid peroxidation by inhibiting Nrf2 signaling. Additionally, shikonin and/or RSL3 potently inhibited the invasion and migration of HTR-8/SVneo cells. Conclusion This study firstly showed that ferroptosis may be involved in TP pathogenesis and shikonin potentially targeted ferroptosis to treat TP.

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Copper/Zinc Ratio Can Be a Marker to Diagnose Ectopic Pregnancy and Is Associated with the Oxidative Stress Status of Ectopic Pregnancy Cases

Cited by 13 publications

References 39 publications

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Effect of Bis(maltolato)oxovanadium(IV) on Zinc, Copper, and Manganese Homeostasis and DMT1 mRNA Expression in Streptozotocin-Induced Hyperglycemic Rats

Trace element concentrations in blood samples from dairy cows with uterine torsion and their neonatal calves

Shikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity

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