Copresence of High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon

Nagi, Karim; Gupta, Ishita; Jurdi, Nawaf; Yasmeen, Amber; Vranić, Semir; Batist, Gerald; Moustafa, Ala-Eddin Al

doi:10.3390/ijms22158118

Cited by 10 publications

(13 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, since our study reports a fairly low prevalence of HPV 16 (4%) infections in the Qatari CRC population, the absence of HPV reported by Khabaz [ 45 ] may be due to the use of detection methods that were based on detecting only HPV 16 and HPV 18 infections, which may be low-occurring in the GCC region. Further, in the larger MENA region, a higher prevalence of HPV in CRC was noted in Syria (54%) [ 32 ] and Lebanon (64%) [ 50 ], which is comparable to the results from our study. Interestingly, the highest prevalence of HPV in CRC in the MENA region comes from Turkey, where studies reported 81% [ 51 ] and 82% [ 52 ] of CRC samples to have HPV infections.…”

Section: Discussionsupporting

confidence: 89%

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

et al. 2023

Self Cite

View full text Add to dashboard Cite

High-risk human papillomaviruses (HPVs) are considered risk factors in the origin of several human malignancies, such as breast, cervical, head and neck, as well as colorectal cancers. However, there are no data reported on the HPV status in colorectal cancer in the State of Qatar. Therefore, we herein examined the presence of high-risk HPVs (16, 18, 31, 33, 35, 45, 51, 52, and 59), using polymerase chain reaction (PCR) in a cohort of 100 Qatari colorectal cancer patients, and their association with tumor phenotype. We found that high-risk HPV types 16, 18, 31, 35, 45, 51, 52, and 59 were present in 4, 36, 14, 5, 14, 6, 41, and 17% of our samples, respectively. Overall, 69 (69%) of the 100 samples were HPV positive; among these, 34/100 (34%) were positive for single HPV subtypes, while 35/100 (35%) of the samples were positive for two or more HPV subtypes. No significant association was noted between the presence of HPV and tumor grade, stage, or location. However, the presence of coinfection of HPV subtypes strongly correlated with advanced stage (stage 3 and 4) colorectal cancer, indicating that the copresence of more than one HPV subtype can significantly worsen the prognosis of colorectal cancer. The results from this study imply that coinfection with high-risk HPV subtypes is associated with the development of colorectal cancer in the Qatari population.

show abstract

Section: Discussionsupporting

confidence: 89%

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Finally, the reported data relied on a single methodology (PCR assay for all three viruses). Nevertheless, our previous studies exploring the presence of HPV and EBV in different types of cancers using PCR and IHC generated comparable results [ 19 , 34 , 53 , 54 , 55 ].…”

Section: Discussionmentioning

confidence: 87%

Incidence of HPVs, EBV, and MMTV-Like Virus in Breast Cancer in Qatar

Gupta¹,

Al-Sarraf²,

Farghaly³

et al. 2022

Intervirology

Self Cite

View full text Add to dashboard Cite

Introduction: Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these oncoviruses and their crosstalk in breast cancer is still unclear. Methods: We explored the co-presence of high-risk HPVs, EBV, and MMTV-like virus in 74 breast cancer samples from Qatar using PCR. Results: We found the presence of HPV and EBV in 65% and 49% of our cancer samples cohort; 47% of the samples are positive for both oncoviruses. The MMTV-like virus alone was detected in 15% of the samples with no significant association with clinicopathological features. The three oncoviruses were co-present in 14% of the cases; No significant association was noted between the co-presence of these viruses and the clinicopathological features. Conclusion: Despite the presence of the oncoviruses, additional studies are necessary to understand their interactions in human breast carcinogenesis.

show abstract

“…In Lebanon, our group reported HPV prevalence in 60 cases out of the 94 CRC samples (64%), with HPV-16 and HPV-18 as the most frequent HR-HPV subtypes [17].…”

Section: In Levant Countriesmentioning

confidence: 85%

“…On the other hand, high-risk HPVs (types -16, -18, -31, -33, -35, -39, -45, -51, -52, -55, -56, -58, -59, -68, -73, -82, and -83) have oncogenic potential and are associated with the development of human cancers [9]; HPV 16 and HPV18 are frequently present in cervical cancer where more than 96% of these cancers are positive for these viruses [14,15]. Subsequently, high-risk HPVs are shown to be involved in a subset of other genital cancers in addition to head and neck, colorectal, and breast cancers [16][17][18][19][20]. Several studies investigated the presence of HPVs in cancer and found the presence of high-risk HPVs correlated with vascular invasion, lymph node metastasis, and tumor grade and size [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

et al. 2022

Self Cite

View full text Add to dashboard Cite

The human papillomavirus (HPV) is a non-enveloped double-stranded DNA virus capable of infecting skin and mucosa epithelial cells. Commonly, HPV infection is associated with sexually transmitted diseases and is considered the leading cause of cervical cancer and other carcinomas of the anogenital tract. However, several studies reported their involvement in cancers of non-sexual regions, including colorectal, head and neck, and breast cancers. There are several studies from the Middle East and North Africa (MENA) regions on the potential association between high-risk HPVs and cancer; nevertheless, there are limited studies that address the significance of HPV vaccination as a potential guard against these cancers. In the current review, we present a comprehensive description of the current HPV-associated cancers prevalence rates in the MENA region, demonstrating their steady increase with time, especially in African regions. Moreover, we discuss the potential impact of vaccination against HPV infections and its outcome on human health in this region.

show abstract

Copresence of High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon

Cited by 10 publications

References 95 publications

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

Coinfection of HPVs Is Associated with Advanced Stage in Colorectal Cancer Patients from Qatar

Incidence of HPVs, EBV, and MMTV-Like Virus in Breast Cancer in Qatar

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

Contact Info

Product

Resources

About