Cord blood irisin at the extremes of fetal growth

Baka, Stavroula; Malamitsi‐Puchner, Ariadne; Boutsikou, Τheodora; Boutsikou, Maria; Marmarinos, Antonios; Hassiakos, Dimitrios; Gourgiotis, Dimitrios; Briana, Despina D.

doi:10.1016/j.metabol.2015.07.020

Cited by 27 publications

(24 citation statements)

References 41 publications

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“…The newborn irisin concentrations in our study were similar to those reported by Baka et al [15]. However, irisin levels did not correlate with newborn weight in this study, which differed from the results of Çağlar et al and Baka et al [15, 29].…”

Section: Discussionsupporting

confidence: 59%

“…However, irisin levels did not correlate with newborn weight in this study, which differed from the results of Çağlar et al and Baka et al [15, 29]. We also found no correlation between umbilical artery irisin and gestational age, which is similar to the results of Ebert el al.…”

Section: Discussioncontrasting

confidence: 51%

“…Interestingly, irisin levels are lower in pregnant women with gestational DM (GDM) compared to body mass index (BMI)-matched glucose tolerant patients [12–14]. Maternal metabolic alterations can lead to complications such as macrosomia in newborns, and recent reports have shown that newborn irisin levels correlated with birthweight [15]. In addition, lower irisin levels have been found in cord blood samples from newborns with intrauterine growth restriction, which may result in less browning of adipose tissue in these babies [16].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn

et al. 2016

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IntroductionIrisin is considered to be a myokine and adipokine that may also participate in reproductive functions, as it increases significantly throughout pregnancy. However, the regulation of circulating irisin and its relationship with other cytokines has not been assessed thus far in pregnant women and their offspring.ObjectiveThe aim of this study was to evaluate differences in irisin and cytokine concentrations between women at the end of pregnancy and their offspring, as well as the relationship between maternal and newborn irisin and maternal and newborn biomarkers.MethodsTwenty-eight mother/newborn pairs were included in this study. The following biomarkers were evaluated in maternal venous and arterial umbilical cord blood samples: irisin, 27 cytokine panel, total antioxidant capacity (TAC), total plasma protein, and free fatty acid concentration.ResultsThe newborns had significantly lower irisin concentrations compared to their mothers (p = 0.03), but this difference was present only in babies born from mothers without labor prior to cesarean section delivery (p = 0.01). No significant differences in maternal and newborn irisin concentrations were found between diabetic and non-diabetic mothers or between overweight/obese and normal weight mothers. A significant positive correlation was found between TAC level and irisin concentration in newborns. Maternal and newborn interleukin (IL)-1β, IL-1RA, IL-5, IL-7, and interferon gamma-induced protein (IP)-10 levels were significantly positively correlated with irisin concentrations in both study groups. In addition, maternal IL1β, IL-5, IL-7, and IP-10 levels positively predicted maternal irisin concentrations. Furthermore, arterial cord blood TAC and IL-1β and IL1-RA levels positively predicted newborn irisin concentrations. Multiple regression analyses showed that maternal IL-13 negatively predicted offspring irisin levels (p = 0.03) and that maternal IL-1β positively predicted newborn irisin concentrations (p = 0.046).ConclusionNo evidence was found that serum irisin concentrations in mothers at pregnancy termination or those of their newborns correlated with maternal body mass index, the presence of diabetes mellitus, or free fatty acid levels. However, the results of this study indicated that cytokines might predict irisin concentration in mothers and their offspring, although interactions between irisin levels during pregnancy and the newborn have not yet been fully elucidated.

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Section: Discussionsupporting

confidence: 59%

Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

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Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn

et al. 2016

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“…Baka et al [22] observed lower irisin in SGA than AGA, but similar levels between LGA and AGA. They also observed that irisin was positively correlated with birth-weight.…”

Section: Study Aim Main Findingsmentioning

confidence: 86%

“…Clinical studies Baka (2015) [22] Humans; cross-sectional Evaluation of cord blood irisin in LGA, SGA and AGA singleton full-term pregnancies.…”

Section: Study Aim Main Findingsmentioning

confidence: 99%