Corneal nerve plexus changes induced by Oxaliplatin chemotherapy and Ergothioneine antioxidant supplementation

Tyler, Ellen F.; Misra, Stuti; McGhee, Charles N J; Zhang, Jie

doi:10.1111/ceo.13685

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…It is a powerful antioxidant with excellent ROS (reactive oxygen species) scavenging capacity and strong inhibition of lipid peroxides [2,3]. It also plays important roles in the improvement of a variety of diseases, including cancer, inflammation, depression and neurological diseases [4][5][6][7][8][9]. Human beings cannot synthesize EGT directly, but EGT can be ingested through diet [10].…”

Section: Introductionmentioning

confidence: 99%

Ergothioneine Production by Submerged Fermentation of a Medicinal Mushroom Panus conchatus

Zhu

Han

et al. 2022

Fermentation

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Ergothioneine is a natural and safe antioxidant that plays an important role in anti-aging and the prevention of various diseases. This study aimed to report on a kind of medicinal mushroom of Panus conchatus with great potential for the bioproduction of ergothioneine. The effect of different nutritional and environmental conditions on the growth of Panus conchatus and ergothioneine production were investigated. Molasses and soy peptone were found to promote cell growth of Panus conchatus and enhance ergothioneine accumulation. Adding precursors of histidine, methionine and cysteine could increase ergothioneine production and the highest ergothioneine concentration of 148.79 mg/L was obtained. Finally, the extraction and purification processes were also established to obtain the crude ergothioneine extract for further antioxidant property evaluation. The ergothioneine from Panus conchatus showed high antioxidant activity with good stability in a lower pH environment. This study provided a new strain and process for the bioproduction of ergothioneine.

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Section: Introductionmentioning

confidence: 99%

Ergothioneine Production by Submerged Fermentation of a Medicinal Mushroom Panus conchatus

Zhu

Han

et al. 2022

Fermentation

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show abstract

“…EGT is a powerful antioxidant, an excellent scavenger of reactive oxygen species (ROS) and an inhibitor of lipid peroxides (Chaves et al 2019;Pahila et al 2017). It has been linked to the improvement of a variety of diseases, including cancer, in ammation, depression and neurological diseases (Yoshida et al 2019;Cheah et al 2017;Cao et al 2020;Nakamichi et al 2016;Nishida et al 2018;Tyler et al 2020). Human beings cannot synthesize EGT directly, but EGT can be ingested through diet (Han et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Process Development of Ergothioneine by Submerged Fermentation of a Novel Medicinal Mushroom Panus Conchatus

Zhu

Han

et al. 2021

Preprint

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Ergothioneine is a natural and safe antioxidant playing an important role in anti-aging and the prevention of various diseases. Mushrooms are the main dietary source of ergothioneine. This study aims to report a kind of medicinal mushroom Panus conchatus with great potential for the bioproduction of ergothioneine. Molasses and soy peptone could promote cell growth of Panus conchatus and enhance the accumulation of ergothioneine. Meanwhile, three precursors of cysteine, histidine and methionine were added to the broth, and the highest ergothioneine concentration of 148.79mg/L was obtained when adding 0.4 g/L cysteine. Finally, the crude ergothioneine extract was purified and further evaluated. The ergothioneine from Panus conchatus showed higher antioxidant activity than vitamin C and glutathione with good stability at lower pH environment. This research would provide a new method for the bioproduction of ergothioneine and lay foundation for the in-depth study about the exploration of natural products from Panus conchatus.

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“…between ocular surface dysfunction and sub-basal corneal nerve damage in neuropathic conditions, particularly diabetic peripheral neuropathy [16][17][18] , evidence is minimal for chemotherapy-induced peripheral neuropathy 19,20 . In-vivo corneal confocal microscopy has been proposed as a useful clinical and research instrument for detecting small nerve fiber changes of the corneal sub-basal nerve plexus in ocular diseases particularly dry eye disease 21 , as well as in the context of diabetic peripheral neuropathy 22,23 with emerging evidence with neurotoxic chemotherapy from both human and animal studies 19,24 . Images acquired from in-vivo corneal confocal microscopy can be reliably and accurately evaluated for corneal nerve parameters with particular software programs such as ACCMetrics 25,26 .…”

mentioning

confidence: 99%

A cross-sectional study of ocular surface discomfort and corneal nerve dysfunction after paclitaxel treatment for cancer

Chiang

Goldstein

Trinh

et al. 2021

Sci Rep

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Ocular surface dysfunction is common in patients receiving anti-cancer drug treatment. The effects of paclitaxel, a neurotoxic chemotherapeutic drug, on ocular surface discomfort associated with dry eye disease was investigated. Patients with cancer who had completed paclitaxel treatment between 3 and 24 months prior to assessment (n = 29) and age- and sex-matched healthy control subjects (n = 29) were recruited and assessed with the Ocular Surface Disease Index (OSDI) to measure ocular surface discomfort. In-vivo corneal confocal microscopy was used to evaluate corneal nerve parameters in the right eye. Peripheral neurotoxicity was assessed using patient-reported outcomes and clinical grading scales. The paclitaxel group had significantly worse OSDI total scores compared with controls (Median, Md = 19.3 and Md = 0, p = 0.007, respectively). Corneal nerve fiber and inferior whorl lengths were reduced in the paclitaxel group compared with controls (14.2 ± 4.0 and 14.4 ± 4.0 mm/mm2 vs. 16.4 ± 4.0 and 16.9 ± 4.9 mm/mm2, respectively, p = 0.04). When analyzed by presence of peripheral neuropathy, paclitaxel-treated patients with neuropathy showed worse OSDI total scores compared to those without peripheral neuropathy post-treatment (p = 0.001) and healthy controls (p < 0.001). More severe ocular discomfort and worse visual function was associated with greater peripheral neurotoxicity symptoms (r = 0.60, p = 0.001) and neuropathy severity (r = 0.49, p = 0.008), respectively. Patients who have been treated with paclitaxel have a higher risk of ocular surface discomfort associated with dry eye disease, particularly those with peripheral neuropathy. Future longitudinal studies should investigate the clinical impact of corneal nerve reduction in dry eye disease.

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Corneal nerve plexus changes induced by Oxaliplatin chemotherapy and Ergothioneine antioxidant supplementation

Cited by 8 publications

References 5 publications

Ergothioneine Production by Submerged Fermentation of a Medicinal Mushroom Panus conchatus

Ergothioneine Production by Submerged Fermentation of a Medicinal Mushroom Panus conchatus

Process Development of Ergothioneine by Submerged Fermentation of a Novel Medicinal Mushroom Panus Conchatus

A cross-sectional study of ocular surface discomfort and corneal nerve dysfunction after paclitaxel treatment for cancer

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