Coronary Stents

Garg, Scot; Serruys, Patrick W.

doi:10.1016/j.jacc.2010.06.007

Cited by 448 publications

(121 citation statements)

References 379 publications

(293 reference statements)

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“…Second generation drug-eluting stents (DES) such as everolimus-eluting stents (EES) and zotarolimus-eluting stents are the treatment of choice for ACS patients because of their superiority in terms of reducing subsequent revascularizations [3]. The most critical limit of DES as metal stent is the permanent caging of the coronary vessel, which increases the risk of neointima proliferation and very late stent thrombosis (ST) and may render surgical revascularization no longer feasible for patients with severe diffuse disease [4][5][6][7]. Recently, bioresorbable vascular scaffolds (BRS) were introduced, which provide temporary vessel scaffolding with drug delivery capacity but do not carry the limitations of a permanent metallic stent in the long term [8,9].…”

Section: Introductionmentioning

confidence: 99%

Impact of postdilatation on performance of bioresorbable vascular scaffolds in patients with acute coronary syndrome compared with everolimus-eluting stents: A propensity score-matched analysis from a multicenter “real-world” registry

et al. 2016

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Background: Safety and efficacy of bioresorbable vascular scaffolds (BRS) and the role of postdilatation on outcome in acute coronary syndrome (ACS) patients compared with those of everolimus-eluting stents (EES) remain unknown. The aim of the study is to compare the safety and efficacy of BRS with EES in ACS and without, comparable to EES patients (6.0% vs. 12.6% vs. 4.7%, p < 0.001). The same trend was observed for TLR (3.4% vs. 8.4% vs. 1.9%, p < 0.001 (Cardiol J 2016; 23, 4: 374-383)

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Section: Introductionmentioning

confidence: 99%

Impact of postdilatation on performance of bioresorbable vascular scaffolds in patients with acute coronary syndrome compared with everolimus-eluting stents: A propensity score-matched analysis from a multicenter “real-world” registry

et al. 2016

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“…Fast-release ZES (Endeavour, Medtronic) has shown a significant difference in clinical performance against paclitaxel-eluting stents (PES), as shown by significant risk reduction in late and very late stent thrombosis, cardiac death, and myocardial infarction [14,15]. On the other hand, at longer follow-up the excellent safety profile did not translate into efficacy, with inferior rates of angiographic surrogates of restenosis and target vessel failure when compared to SES and PES [15][16][17]. Following these results, fast-release ZES were replaced by slow-release counterparts yielding improved neointimal inhibition [7] and non-inferior clinical outcomes when compared to everolimus eluting stents [18].…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent vascular response following delivery of sirolimus via fast releasing, biodegradable polymer stent matrix: an experimental study in the porcine coronary model of restenosis

et al. 2015

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A b s t r a c tBackground: Fast releasing, rapamycin-eluting stents, although safe, showed inferior results with regard to inhibition of restenosis.Aim: Therefore, we report vascular effects of a novel, biodegradable polymer stent matrix with elevated sirolimus dose and fast release kinetics (ed-frSES, Alex, Balton) in the porcine coronary in-stent restenosis model. Methods:A total of 19 stents were implanted with 120% overstretch in the coronary arteries of seven domestic pigs: seven ed-frSES with 1.3 μg/mm 2 of sirolimus, eight frSES with 1 μg/mm 2 of sirolimus, and eight bare metal stents (BMS). For the following 28 days, coronary angiography was performed, animals were sacrificed, and the stented segments harvested for histopathological evaluation. Results:In angiography at 28 days the late lumen loss was lowest in the elevated dose sirolimus eluting stent (SES) (ed-frSES: 0.20 ± 0.2 vs. frSES: 0.80 ± 0.5 vs. BMS: 0.96 ± 0.5 mm, p < 0.01). This was confirmed in the morphometric evaluation in histopathology as represented by a significant and dose-dependent decrease in the percentage area of stenosis (ed-frSES: 22.4 ± 12.7% vs. frSES: 35 ± 10.7% vs. BMS: 47.5 ± 12.5%, p < 0.01). There was no peri-strut inflammation in any of the groups. However, the endothelialisation score was numerically not meaningfully decreased in ed-frSES (ed-frSES: 2.93 vs. frSES: 3. vs. BMS: 3, p = 0.05). Signs of fibrin were also noted in ed-frSES (ed-frSES: 0.4 vs. frSES: 0 vs. BMS: 0, p = 0.05). Conclusions:Sirolimus dose-dependent vascular response was reported. The elevated dose, fast releasing SES shows satisfactory vascular healing, similar to regular dose, fast release SES, with improved efficacy in restenosis inhibition.

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“…[3] Fourty years ago, coronary artery bypass surgery (CABG) was the popular revascularization treatment used to treat obstructive coronary artery diseases. However, it was claimed that frequent coronary closures occurred and hence emergency surgical revascularization was necessary [4,5].…”

Section: Introductionmentioning

confidence: 99%

Non Linear Bending Analysis on Stent Materials used as Cardiovascular Implants

Kumar¹,

Ramesha²

2017

International Advanced Research Journal in Science, Engineering

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Cardiovascular disease such as atherosclerosis is one of the most common diseases in modern days which may cause pain and heart attack. Stenting is non surgical method to treat the atherosclerosis. Due to its efficiency and simplicity, the use of coronary stents in interventional procedures has rapidly increased and different stents have been introduced in the market. In order to have better output of the stent implantation, it is needed to analyze the mechanical behavior of this device before manufacturing and utilizing. The aim of this work is to investigate the biomechanical behavior of stent such as non linear bending analysis at different loading conditions by using different biomaterials. One of the most effective methods to investigate the biomechanical behavior of the stent is finite element method. A commercially available finite element package ABAQUS6.10 has been used for the analysis.

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Coronary Stents

Cited by 448 publications

References 379 publications

Impact of postdilatation on performance of bioresorbable vascular scaffolds in patients with acute coronary syndrome compared with everolimus-eluting stents: A propensity score-matched analysis from a multicenter “real-world” registry

Impact of postdilatation on performance of bioresorbable vascular scaffolds in patients with acute coronary syndrome compared with everolimus-eluting stents: A propensity score-matched analysis from a multicenter “real-world” registry

Dose-dependent vascular response following delivery of sirolimus via fast releasing, biodegradable polymer stent matrix: an experimental study in the porcine coronary model of restenosis

Non Linear Bending Analysis on Stent Materials used as Cardiovascular Implants

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