High myopia, or extreme nearsightedness, is a leading cause of blindness worldwide, especially when it progresses to pathologic myopia. Currently, no method exists to assess myopia development and severity quantitatively in vivo. Myopia is typically evaluated with measurements of axial length and refractive error. While these measures are useful to provide guidance for vision correction and are correlated with increased risk of pathologic myopia, they provide no direct information about the progression of pathologic changes within the eye tissues. Nor can these measures alone predict the likelihood of vision-threatening staphyloma formation in the posterior region of the eye.In myopia, images are focused anterior to, rather than upon, the retina. 1 More than 95% of myopia cases result from excessive axial length in the eye. 2 Globally, myopia affects up to 2.3 billion people, 3 and the prevalence is rising