Correction of Lipid Metabolism Disorders in Diabetes Mellitus with Peptide Drugs

Елагина, Анна Александровна; Lyashev, Yu. D.; Lyashev, A. Yu.; Pronyaeva, T V; Chahine, Abou

doi:10.1007/s10517-020-04764-2

“…It is demonstrated that T2DM patients with lipid metabolism disorder have a higher risk of DPN. Some studies have shown that even if the blood glucose is normal, it cannot recover the nerve damage caused by long-term hyperglycemia and that DPN can occur independently of the blood glucose level, which also confirms that the disorder of lipid metabolism is also an important risk factor for promoting DPN [ 36 ]. Lipid metabolism is an important biochemical reaction in which fat finally produces substances needed by the human body through a series of complex reactions so as to maintain the normal life activities of the human body.…”

Section: Discussionmentioning

confidence: 92%

Correlation Analysis and Intervention Study on Disturbance of Lipid Metabolism and Diabetic Peripheral Neuropathy

Wang

¹

,

Li

²

,

Ren

³

2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the significance and clinical value of dynamic monitoring of lipid metabolism indexes in patients with diabetic peridiabetic lesions. Methods. A total of 192 patients with type 2 diabetes (T2DM) treated in our hospital from October 2019 to July 2021 were divided into two groups according to whether they were complicated with peripheral neuropathy (DPN). The patients in the observation group were randomly assigned into group A ( n = 45 ) and group B ( n = 45 ) according to the method of random number table. The patients were assigned into control group ( n = 102 ) and observation group ( n = 90 ), and the patients in the observation group were randomly divided into two groups ( n = 45 ). All the patients in the three groups were given routine hypoglycemic treatment, and group B was observed to dynamically monitor the indexes of lipid metabolism and regulate blood lipids on the basis of routine hypoglycemic treatment. The indexes of lipid metabolism, including total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C)/low-density lipoprotein cholesterol (LDL-C), were detected before treatment. The receiver operating curve (ROC) was applied to elucidate the efficacy of TC, TG, and HDL-C and LDL-C in predicting peripheral neuropathy (DPN) in patients with T2DM. The indexes of lipid metabolism and neurological function of patients were determined after the treatment. The difference was considered to be statistically significant ( P < 0.05 ). Results. In contrast to the control, the serum levels of TG, TC, and LDL-C in the observation group were significantly higher, with HDL-C significantly lower. ROC curve analysis indicated that the area under the curve (AUC) of serum TG level to predict peripheral neuropathy in patients with T2DM was 0.753 (95% CI = 0.604 − 0.901 , P = 0.007 ). When the Youden index reached the maximum (0.677), with corresponding sensitivity and specificity 77.18% and 82.58%, respectively, and the critical value was 2.31 mmol/L, the AUC of serum TC level for predicting peripheral neuropathy in patients with T2DM was 0.851 (95% CI = 0.735 ~ 0.967 P < 0.001 ); when the Youden index reaches its maximum (0.750), with the sensitivity and specificity 84.44% and 92.06%, respectively, and the critical value is 4.52 mmol/L, the AUC of predicting peripheral neuropathy in patients with T2DM by serum LDL-C level was 0.799 (95% CI = 0.52 ~ 0.946 , P = 0.001 ); when the Youden index reaches its maximum (0.706), with sensitivity and specificity 80.58% and 87.24%, respectively, and the critical value is 3.36 mmol/L, the AUC of serum HDL-C level for predicting DPN in patients with T2DM was 0.727 (95% CI = 0.568 ~ 0.886 P = 0.014 ). When the Youden index reached the maximum (0.640), the sensitivity and specificity were 74.56% and 83.25%, respectively, the critical value is 1.51 mmol/L. The AUC in predicting DPN in patients with T2DM was 0.919 (95% CI = 0.839 ~ 0.978 P < 0.001 ); when the Jordan index reached the maximum (0.786), the sensitivity and specificity were 91.75% and 95.82%, respectively. Compared with group A, the levels of serum TG, TC, and LDL-C in group B decreased significantly, while the level of HDL-C increased ( P < 0.05 ). The motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and peroneal nerve in group B were higher than those in group A ( P < 0.05 ). Conclusion. Diabetic patients with severe lipid metabolic disorders have a higher risk of DPN. Combined detection of lipid metabolism indexes such as TC, TG, and HDL-C and LDL-C is effective in predicting diabetic patients with DPN. In clinic, through dynamic monitoring of lipid metabolism indexes, we can actively regulate the level of blood lipids in patients with T2DM, which can delay the occurrence and development of DPN to a certain extent, as well as improving the prognosis of patients with diabetes.

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“…Although significant progress has been achieved in the knowledge and development of hypolipidemic medications, side effects have also become apparent ( Olzmann and Carvalho, 2019 ). Currently used hypolipidemic drugs administered to regulate LMD are suboptimal as they may cause liver or kidney damage, adverse gastrointestinal reactions, and organismic and other side effects of drug resistance ( Elagina et al, 2020 ). As natural cholesterol-lowering active food ingredients are urgently needed, functional compounds isolated from natural foods are increasingly acknowledged to alleviate LMD ( Li et al, 2019 ; Yang et al, 2020 ; Zhang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids

Tong

¹

,

Wu

²

,

Chen

³

et al. 2023

Current Research in Food Science

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“…Excessive alcohol consumption and/or alcohol-carbohydrate mixtures can damage subcellular components, cells, organs, and the whole organism [1][2][3]. Mostly, alcohol causes oxidative stress [4,5].…”

Section: Introductionmentioning

confidence: 99%

Bio protectors’ effect on the composition of some amino acids under alcohol-induced oxidative stress

Калачнюк

¹

,

Fedyshyn

²

,

Smirnov

³

et al. 2021

Eureka: LS

1

0

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The studies, which may reveal some elements of regulation between the metabolic processes of proteins (at the level of translation and changes in the amino acid spectrum) as well as catabolism and anabolism of carbohydrates under conditions of pathological deviations of the functioning of the animal organism, are promising, and the search for protective substances of a different nature is necessary. The aim is to study and analyze a bio protectors’ effect on the composition of some amino acids under alcohol-induced oxidative stress. During the experimental period, changes in the body weight of rats confirm the depressant effect of alcohol on the dynamics of weight gain of animals during their growth and development, and the positive protective effect of betaine and additives (protein+minerals). The increased activity of alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase in the blood serum of rats in experimental groups of animals with the absence of protectors’ substances in the diet indicates a deviation in the functional capacity of the liver. The determined indices of the content of creatinine and urea were increased significantly that points out on possible pathological deviation of the kidney. Under alcohol substances, changes of such biochemical indexes value as lactate dehydrogenase, superoxide dismutase, and catalase, and the content of malonic dialdehyde indicate oxidative stress. In the case of bio protectors’ presence, values of biochemical parameters become to ones in the animals of control groups. It was observed, that betaine has a higher potential for the correction of the above pathological abnormalities than protein-containing additives with minerals in the form of chelate, but the last is perspective for further study and their use as a raw material for the development of more complex bio protectors

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Correction of Lipid Metabolism Disorders in Diabetes Mellitus with Peptide Drugs

Cited by 3 publications

References 4 publications

Correlation Analysis and Intervention Study on Disturbance of Lipid Metabolism and Diabetic Peripheral Neuropathy

Correlation Analysis and Intervention Study on Disturbance of Lipid Metabolism and Diabetic Peripheral Neuropathy

Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids

Bio protectors’ effect on the composition of some amino acids under alcohol-induced oxidative stress

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