Correction to: Anti-inflammatory and antioxidant effects of 2, 7-dihydroxy-4, 6-dimethoxy phenanthrene isolated from Dioscorea batatas Decne

Lim, Ji Sun; Hahn, Dongyup; Gu, Myeong Ju; Oh, Jisun; Lee, Jeong Soon; Kim, Jong-Sang

doi:10.1186/s13765-019-0442-4

Cited by 4 publications

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, if the inflammation is associated with disease or a problem in metabolism, the ROS may not be effectively removed [ 3 ]. As the inflammatory reaction progresses, mass production of ROS can result in fatal damage to surrounding tissues [ 4 , 5 ]. To prevent such damage, it may be useful to ingest supplementary antioxidants [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Flavonoids from Brugmansia arborea L. Flowers

Kim

Jang

Jung

et al. 2020

Journal of Microbiology and Biotechnology

View full text Add to dashboard Cite

Brugmansia arborea L. (Solanaceae), commonly known as "angel's trumpet," is widely grown in North America, Africa, Australia, and Asia. It has been mainly used for ornamental purposes as well as analgesic, anti-rheumatic, vulnerary, decongestant, and anti-spasmodic materials. B. arborea is also reported to show anti-cholinergic activity, for which many alkaloids were reported to be principally responsible. However, to the best of our knowledge, a phytochemical study of B. arborea flowers has not yet been performed. Four flavonol glycosides (1-4) and one dihydroflavanol (5) were for the first time isolated from B. arborea flowers in this study. The flavonoids showed significant antioxidant capacities, suppressed nitric oxide production in lipopolysaccharide (LPS)-treated RAW 264.7 cells, and reduced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) protein production increased by LPS treatment. The contents of compounds 1-4 in n-BuOH fraction were determined to be 3.8 ± 0.9%, 2.2 ± 0.5%, 20.3 ± 1.1%, and 2.3 ± 0.4%, respectively, and that of compound 5 in EtOAc fraction was determined to be 12.7 ± 0.7%, by HPLC experiment. These results suggest that flavonol glycosides (1-4) and dihydroflavanol (5) can serve as index components of B. arborea flowers in standardizing anti-inflammatory materials.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Flavonoids from Brugmansia arborea L. Flowers

Kim

Jang

Jung

et al. 2020

Journal of Microbiology and Biotechnology

View full text Add to dashboard Cite

show abstract

Potential role of a novel biphenanthrene derivative isolated from Aerides falcata in central nervous system diseases

et al. 2023

View full text Add to dashboard Cite

show abstract

Structural and kinetic insights into flavin-containing monooxygenase and calponin-homology domains in human MICAL3

Kim

Lee

Roh

et al. 2020

IUCrJ

View full text Add to dashboard Cite

MICAL is an oxidoreductase that participates in cytoskeleton reorganization via actin disassembly in the presence of NADPH. Although three MICALs (MICAL1, MICAL2 and MICAL3) have been identified in mammals, only the structure of mouse MICAL1 has been reported. Here, the first crystal structure of human MICAL3, which contains the flavin-containing monooxygenase (FMO) and calponin-homology (CH) domains, is reported. MICAL3 has an FAD/NADP-binding Rossmann-fold domain for monooxygenase activity like MICAL1. The FMO and CH domains of both MICAL3 and MICAL1 are highly similar in structure, but superimposition of the two structures shows a different relative position of the CH domain in the asymmetric unit. Based on kinetic analyses, the catalytic efficiency of MICAL3 dramatically increased on adding F-actin only when the CH domain was available. However, this did not occur when two residues, Glu213 and Arg530, were mutated in the FMO and CH domains, respectively. Overall, MICAL3 is structurally highly similar to MICAL1, which suggests that they may adopt the same catalytic mechanism, but the difference in the relative position of the CH domain produces a difference in F-actin substrate specificity.

show abstract

Correction to: Anti-inflammatory and antioxidant effects of 2, 7-dihydroxy-4, 6-dimethoxy phenanthrene isolated from Dioscorea batatas Decne

Cited by 4 publications

References 1 publication

Anti-Inflammatory Effect of Flavonoids from Brugmansia arborea L. Flowers

Anti-Inflammatory Effect of Flavonoids from Brugmansia arborea L. Flowers

Potential role of a novel biphenanthrene derivative isolated from Aerides falcata in central nervous system diseases

Structural and kinetic insights into flavin-containing monooxygenase and calponin-homology domains in human MICAL3

Contact Info

Product

Resources

About