Correlation Analysis between Gut Microbiota and Metabolites in Children with Systemic Lupus Erythematosus

Wen, Min; Liu, Taohua; Zhao, Mingyi; Dang, Xiqiang; Feng, Shipin; Ding, Xuewei; Xu, Zhongneng; Huang, Xiaoyan; Lin, Qiuyu; Xiang, Wei; Li, Xiaoyan; He, Xiaoqing; He, Qing

doi:10.1155/2021/5579608

Cited by 28 publications

(24 citation statements)

References 40 publications

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“…Newly diagnosed treatment-naive SLE cases ( 44 ) and SLE patients that had not received glucocorticoid (GC) therapy ( 45 ) possessed a decrease of Lactobacillus in feces in Chinese and Egyptian patients compared with the healthy controls. However, SLE patients in most cohorts both active and remissive, both adults and children all manifested the enrichment of Lactobacillus in both fecal and oral sample in China and Netherlands ( 14 , 15 , 18 , 19 , 46 ) ( Table 1 ). Notably, Lactobacillus enriched in active SLE patients and lupus erythematosus skin lesions patients ( 47 ) as disease severity might play a role in abundance ( 14 ).…”

Section: Lactobacillus Are Altered In Sle Patientsmentioning

confidence: 99%

Lactobacillus: Friend or Foe for Systemic Lupus Erythematosus?

2022

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The cause of Systemic Lupus Erythematosus (SLE) remains largely unknown, despite the fact that it is well understood that a complex interaction between genes and environment is required for disease development. Microbiota serve as activators and are essential to immune homeostasis. Lactobacillus is thought to be an environmental agent affecting the development of SLE. However, beneficial therapeutic and anti-inflammatory effects of Lactobacillus on SLE were also explored. The discovery of Lactobacillus involvement in SLE will shed light on how SLE develops, as well as finding microbiota-targeted biomarkers and novel therapies. In this review, we attempt to describe the two sides of Lactobacillus in the occurrence, development, treatment and prognosis of SLE. We also discuss the effect of different strains Lactobacillus on immune cells, murine lupus, and patients. Finally, we try to illustrate the potential immunological mechanisms of Lactobacillus on SLE and provide evidence for further microbiota-targeted therapies.

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Section: Lactobacillus Are Altered In Sle Patientsmentioning

confidence: 99%

Lactobacillus: Friend or Foe for Systemic Lupus Erythematosus?

2022

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“…In addition, Ruminococcaceae is a family of autochthonous and benign species [ 34 ] that produce short-chain fatty acids and has been well-illustrated to be responsible for the degradation of diverse polysaccharides and fibers [ 35 ]. The population size of Ruminococcaceae is inversely correlated with hepatic encephalopathy, nonalcoholic fatty liver disease, and systemic lupus erythematosus [ 35 , 36 , 37 ], and we detected a decrease in the immune system diseases pathway, which may be due to this bacterium. In the present study, we reported that E2 correlated with the g__Ruminococcus_torques_group .…”

Section: Discussionmentioning

confidence: 85%

Reproductive Hormones Mediate Intestinal Microbiota Shifts during Estrus Synchronization in Grazing Simmental Cows

Wang

Simujide

et al. 2022

Animals

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To study shifts in the intestinal microbiota during estrus synchronization in ruminants, we characterized the intestinal microbiota in grazing Simmental cows and the possible mechanism that mediates this shift. Fourteen postpartum Simmental beef cows were synchronized beginning on day 0 (D0) with a controlled internal release device (CIDR), and cloprostenol was injected on D9 when the CIDR was withdrawn. Synchronization ended with timed artificial insemination on D12. Serum and rectal samples harvested on D0, D9, and D12 were analyzed to assess the reproductive hormones and microbiota. Reproductive hormones in the serum of the host were measured using enzyme-linked immunosorbent assay. The microbiota was characterized using 16S rRNA sequencing of the V3–V4 hypervariable region, alpha diversity and beta diversity analyses (principal coordinate analysis, PCoA), cladogram of the linear discriminant analysis effect size (LEfSe) analysis, and microbiota function analysis. Levels of the reproductive hormones, except gonadotropin-releasing hormone (p > 0.05), shifted among D0, D9, and D12 (p < 0.05). Decreased community diversity (Chao1 and ACE) was observed on D12 compared with D0 (p < 0.05). The beta diversity (PCoA) of the microbiota shifted markedly among D0, D9, and D12 (p < 0.05). The LEfSe analysis revealed shifts in the intestinal microbiota communities among D0, D9, and D12 (p < 0.05 and LDA cutoff >3.0). The KEGG pathway analysis showed that carbohydrate metabolism, genetic information and processing, the excretory system, cellular processes and signaling, immune system diseases, and the metabolism were altered (p < 0.05). Reproductive hormones (especially estradiol) were correlated with the alpha diversity indices, beta diversity indices, and an abundance of biomarkers of the shifting intestinal microbiota (p < 0.05). In conclusion, the structure, composition, and function of the intestinal microbiota were shifted during estrus synchronization in a grazing Simmental cow model, and these shifts were mediated by reproductive hormones.

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“…Our findings of a decreased abundance of Ruminococcaceae in patients with SLE differed from the results of Wen et al . 39 Microbes in this family can produce short-chain fatty acids (SCFAs), 25 which are considered potential ‘orchestrators’ of the cross-talk between the gut microbiota and the host metabolism. 40 A reduction of these microbes may therefore lead to reduced SCFA production and disruptions of human metabolism.…”

Section: Discussionmentioning

confidence: 99%

Association between systemic lupus erythematosus and disruption of gut microbiota: a meta-analysis

Xiang

Qian

et al. 2022

Lupus Sci Med

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ObjectiveRecent studies reported that SLE is characterised by altered interactions between the microbiome and immune system. We performed a meta-analysis of publications on this topic.MethodsCase–control studies that compared patients with SLE and healthy controls (HCs) and determined the diversity of the gut microbiota and the abundance of different microbes were examined. Stata/MP V.16 was used for the meta-analysis. A Bonferroni correction for multiple tests was used to reduce the likelihood of false-positive results.ResultsWe included 11 case–control studies that examined 373 patients with SLE and 1288 HCs. These studies were performed in five countries and nine cities. Compared with HCs, patients with SLE had gut microbiota with lower Shannon-Wiener diversity index (weighted mean difference=−0.22, 95% CI −0.32 to –0.13, p<0.001) and lower Chao1 richness (standardised mean difference (SMD)=−0.62, 95% CI −1.04 to –0.21, p=0.003). Patients with SLE had lower abundance of Ruminococcaceae (SMD = −0.49, 95% CI −0.84 to −0.15,p=0.005), but greater abundance of Enterobacteriaceae (SMD=0.45, 95% CI 0.01 to 0.89, p=0.045) and Enterococcaceae (SMD=0.53, 95% CI 0.05 to 1.01, p=0.03). However, only the results for Ruminococcaceae passed the Bonferroni correction (p=0.0071). The two groups had no significant differences in Lachnospiraceae and Bacteroides (both p>0.05). Patients with SLE who used high doses of glucocorticoids had altered gut microbiota based on the Chao1 species diversity estimator, and hydroxychloroquine use appeared to reduce the abundance of Enterobacteriaceae.ConclusionsPatients with SLE have imbalanced gut microbiota, with a decrease in beneficial bacteria and an increase in harmful bacteria. Drugs used to treat SLE may also alter the gut microbiota of these patients.

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Correlation Analysis between Gut Microbiota and Metabolites in Children with Systemic Lupus Erythematosus

Cited by 28 publications

References 40 publications

Lactobacillus: Friend or Foe for Systemic Lupus Erythematosus?

Lactobacillus: Friend or Foe for Systemic Lupus Erythematosus?

Reproductive Hormones Mediate Intestinal Microbiota Shifts during Estrus Synchronization in Grazing Simmental Cows

Association between systemic lupus erythematosus and disruption of gut microbiota: a meta-analysis

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