Correlation Analysis between Ocular Surface Parameters with Subjective Symptom Severity in Dry Eye Disease

Lee, Jee Hye; Kim, Chang Hwan; Choe, Chul Myong; Choi, Tae Hoon

doi:10.3341/kjo.2019.0133

Cited by 16 publications

(12 citation statements)

References 23 publications

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“…The tear film consists of two phases, a lipid layer overlying a muco-aqueous layer [3]. Tear lipids secreted from the meibomian glands (MG) aids the tear film maintaining its solidity [4]. Meibomian gland dysfunction (MGD), the main cause of evaporative dry eye, is more frequent than aqueous-deficient dry eye [5].…”

Section: Introductionmentioning

confidence: 99%

Relationship between the partial blink rate and ocular surface parameters

et al. 2021

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Purpose To elucidate the relationship between partial blink rate (PBR) and ocular surface parameters. Methods We conducted a retrospective cross-sectional study of the patients who visited the Kim's Eye Hospital between March 2020 and July 2020. Blinking dynamics, tear film lipid layer thickness (LLT), noninvasive tear film break-up time (NITBUT), tear meniscus height (TMH), and meibomian gland (MG) dropout rate were assessed using the IDRA Ò Ocular surface analyzer (SBM SISTEMI, Inc., Torino, Italy) (IDRA). Dry eye symptoms were quantified by the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire scores. Results A total of 47 non-Sjo ¨gren dry eye patients (47 right eyes, mean age = 56.8 ± 14.5 [20-75] years, 66% female) were enrolled. Among the ocular surface parameters, PBR had strong correlations with MG dropout rate (r = 0.811; p \ 0.01) and moderate correlations with SPEED scores (r = 0.596; p \ 0.01). MG dropout rate and age had moderate correlations with SPEED scores (r = 0.416; p = 0.04 and r = 0.322; p = 0.03, respectively). Comparisons by sex revealed no significant difference in characteristics, except for the TMH value. The TMH of female patients (0.17 ± 0.07) was significantly higher than that of males (0.14 ± 0.04; p = 0.04). LLT showed no significant correlation with the other variables. Conclusion PBR and MG dropout rates measured with IDRA were significantly correlated to dry eye symptoms.

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Section: Introductionmentioning

confidence: 99%

Relationship between the partial blink rate and ocular surface parameters

et al. 2021

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“… 43–46 However Lee et al found a correlation between OSDI and NIKBUT for the first breakup time (r= −0.33) and lipid layer thickness (LLT, r= −0.42). 47 Also, Blackie et al reported that LLT was significantly correlated with severe symptoms using the SPEED questionnaire. 48 Due to the low correlation coefficients in both Lee et al, Blackie et al, and our study, the clinical utility of the correlations is questionable.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Dry Eye Disease Among Individuals Scheduled for Cataract Surgery in a Norwegian Cataract Clinic

Jensen¹,

Gundersen²,

Nilsen³

et al. 2023

OPTH

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Purpose To determine the prevalence of dry eye disease (DED) in patients scheduled for cataract surgery in a Norwegian eye clinic. Patients and Methods 218 patients scheduled for cataract surgery were examined for DED in one randomly selected eye and questioned regarding symptoms and risk factors. Patients were diagnosed with DED if they fulfilled the DEWS II criteria with symptom score >12/100 with Ocular Surface Disease Index (OSDI) questionnaire, and the presence of any of the three signs: tear osmolarity >307 mOsm/L in either eye or a difference in osmolarity between the two eyes of >8 mOsm/L, corneal fluorescein staining (CSF) ≥ grade 2 and non-invasive tear film breakup time (NIKBUT) of <10 seconds. Additional tests were the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, tear meniscus height (TMH), Schirmer 1, tear film thickness (TFT), corneal sensitivity and meibography (meiboscore). Dry eye test outcomes were correlated with risk factors for DED. Results The prevalence of DED was 55.5% according to the DEWS II criteria. The abnormal osmolarity percentage was 66.5, while 29.8% had shortened NIKBUT and 19.7% exhibited CFS ≥2. 57% had Schirmer 1 ≤ 10 mm/5 min, and 81.1% had a meiboscore of ≥1. 71.2% of subjects scored positive for DED symptoms using the OSDI questionnaire and 69.3% using SPEED. Logistic regression analysis showed that higher age correlated with a lower OSDI symptom score, reduced corneal sensitivity and increased meibomian gland atrophy. Female sex was associated with higher odds of having DED, abnormal NIKBUT and abnormal CFS. Ocular tests for DED did not correlate with OSDI symptom scores when assessed with Spearman`s rank analysis. Conclusion The prevalence of DED in an elderly Norwegian population scheduled for cataract surgery is high and associated with female sex. There was a lack of correlation between signs and symptoms of DED.

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“…The authors concluded that noninvasive examinations, such as noninvasive keratograph break-up time and interferometry of LLT, could be efficient tools for evaluating dry eye symptoms. 28 …”

Section: Discussionmentioning

confidence: 99%

Changes in Noncontact Meibography and Noninvasive Tear Break-Up Time Test with Contact Lenses Usage

Fattoh¹,

Mounir²,

Anbar³

et al. 2022

OPTH

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Purpose The study aimed to determine changes detected by noncontact meibography and noninvasive break-up time test (NIBUT) in individuals with regular use of soft contact lenses and compare these findings with irregular soft contact lenses wearers who not compliant with them and non-wearers control group. Patients and Methods A prospective nonrandomized case-control study in which individuals were recruited and distributed into three groups: Group A (regular contact lens wearers), group B (irregular contact lens wearers), and group C (non-wearers). Ocular Surface Disease Index (OSDI) was obtained. Noncontact meibography and noninvasive tear break-up time were measured without lenses on using Sirius ® Scheimpflug Camera. Results One hundred sixty-six eyes of 83 individuals were included; 36 eyes in group A, 50 eyes in group B, and 80 eyes in group C. The mean total meiboscore was 1.99, 1.61, and 1.28, respectively. The mean meibograde was 3.03, 2.86, and 1.99, respectively. Noninvasive break-up time (NIF-BUT) was 8.42, 11.76, and 13.57 seconds, respectively. Conclusion There is a difference in OSDI score, meibomian score, and break-up time between different study groups. The study results show that there are trends in lens wearers and non-lens wearers. This is useful for the field to understand the differences between lens wearers and non-lens wearers.

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Correlation Analysis between Ocular Surface Parameters with Subjective Symptom Severity in Dry Eye Disease

Cited by 16 publications

References 23 publications

Relationship between the partial blink rate and ocular surface parameters

Relationship between the partial blink rate and ocular surface parameters

Prevalence of Dry Eye Disease Among Individuals Scheduled for Cataract Surgery in a Norwegian Cataract Clinic

Changes in Noncontact Meibography and Noninvasive Tear Break-Up Time Test with Contact Lenses Usage

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