Correlation between Blood Pressure and Obesity Parameter against Cystatin-C and Adiponectin Levels in Serum of  Obese Adolescent

Ridwan, Ridwan; Febriza, Ami; Linggi, Elmiana Bongga; Natzir, Rosdiana; Tazlim, Nurpudji Astuti

doi:10.21705/mcbs.v4i3.109

Cited by 4 publications

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“…Obesity increases the risk of chronic diseases, such as cardiovascular diseases, stroke, diabetes mellitus, muscle and bone disorders (osteoarthritis). 4,5 There are several proteins that can be used as obesity markers, such as fat mass and obesity-associated (FTO), leptin, and resistin. FTO is an important protein that regulates the development and function of adipose tissue, which adjusts the size and composition of the body.…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking of Citrus amblycarpa Active Compounds against FTO, Leptin, and Resistin Protein

Panghiyangani

Utami

Baitullah

et al. 2023

Mol Cell Biomed Sci

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Background: Citrus amblycarpa has been known to have various pharmacological activities, such as antioxidants, anticancer, antitumor, hepatoprotective, anti-inflammatory, antidiabetic, antiviral, antibacterial, and antifungal. Hesperidin, naringin, quercetin, rutin, gamma (γ)-aminobutyric acid (GABA), neoeriocitrin, and poncirin from C. amblycarpa were the major constituents that potentially act on some obesity proteins, such as fat mass and obesity-associated (FTO) protein, leptin, and resistin, the emerging targets in the treatment of obesity. This study aimed to investigate the interaction between major active compounds of C. amblycarpa with FTO, leptin and resistin.Materials and methods: The ligands of the docking study were seven major chemical compounds found in peel of C. amblycarpa, i.e., hesperidin, naringin, quercetin, rutin, GABA, neoeriocitrin, and poncirin. FTO, leptin and resistin structure were taken from Protein Data Bank, while the C. amblycarpa compounds were prepared using Open Babel integrated into PyRx 8.0. Molecular docking simulation was performed using Autodock Vina integrated into PyRx 8.0. Virtual prediction and visualization of protein–ligand complexes were analyzed and visualized using Discovery Studio.Results: All major compounds of C. amblycarpa peel used in this study did not have hepatotoxicity and AMES toxicity. Hesperidin had the lowest binding affinity score when interacted with FTO, leptin and resistin compared to other compounds. Moreover, GABA had the highest binding affinity score compared to other compounds.Conclusion: Hesperidin may be a candidate obesity protein antagonist and may have potential as a treatment for obesity.Keywords: Citrus amblycarpa, molecular docking, FTO, leptin, obesity, resistin

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Section: Introductionmentioning

confidence: 99%

Molecular Docking of Citrus amblycarpa Active Compounds against FTO, Leptin, and Resistin Protein

Panghiyangani

Utami

Baitullah

et al. 2023

Mol Cell Biomed Sci

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“…(1) Cardiometabolic syndrome is also a risk factor for decreased renal function. (2,3) Cardiometabolic syndrome causes damage to the vascular endothelium which then causes the release of pro-inflammatory cytokines. (4) This can be a predisposing factor for decreased renal function through the process of endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Ganoderma lucidum Polysaccharide Peptide Reduces Oxidative Stress and Improves Renal Function in Patient with Cardiometabolic Syndrome

et al. 2023

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BACKGROUND: Cardiometabolic syndrome is a risk factor for the development of diseases related to cardiovascular disease and decreased renal function. Ganoderma lucidum polysaccharide peptide (GLPP) has been reported to have anti-inflammatory and antioxidant properties. The current study was conducted to investigate the role of GLPP in inflammatory, oxidative stress and renal function markers of cardiometabolic subjects.METHODS: A randomized double-blinded perspective control trial with pre-post design was conducted. Cardiometabolic syndrome subjects were treated with placebo or GLPP for 60 days. Blood serum was collected from each subject before the first capsule consumption and one day after the last capsule consumption. Serum tumor necrosis factor (TNF)-α, high-sensitivity-C-Reactive Protein (hs-CRP) and malondialdehyde (MDA) levels were measured using enzyme-linked immunosorbent assay, while superoxide dismutase (SOD) level was measured using colorimetric assay. Serum urea and creatinine levels were measured using a clinical analyzer. The Cockroft-Gault formula was used to calculate estimated glomerular filtration rate (eGFR).RESULTS: Compared with the control group, the MDA level was significantly reduced, while the SOD level was significantly increased in the GLPP treatment group. Furthermore, serum urea and creatinine were lowered, while eGFR was increased in the GLPP treatment group.CONCLUSION: Treatment of GLPP for 60 days could be beneficial for lowering oxidative stress and improving renal function of patients with cardiometabolic syndrome.KEYWORDS: Ganoderma lucidum, cardiometabolic syndrome, inflammation, oxidative stress, renal function

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“…In addition to traditional risk factors such as diabetes and hypertension, the increased CVD mortality in patients with CKD is also impacted by an increase in oxidative stress and inflammation, which occurs concurrently with a decline in renal function. (4,5) Therefore, continuous assessment of inflammation and oxidative stress is useful to predict CVD risk in the CKD patients. ( 6) Furthermore, genetic variants that induce defective expression of specific proteins, enzymes, and inflammatory mediators may increase the risk of vascular calcification and atherosclerotic CVD (ASCVD).…”

Section: Introductionmentioning

confidence: 99%

The Role of Klotho G395A Gene Polymorphism in Atherosclerotic Cardiovascular Disease and Mortality Risk Scores in Non-dialysis Chronic Kidney Disease

et al. 2022

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BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Klotho expression was reduced in patients with CKD, leading to vascular calcification, endothelial dysfunction, and atherosclerosis. We investigated the role of the klotho G395A gene polymorphism and plasma klotho level in the ten-year risk of atherosclerotic cardiovascular disease (ASCVD) and CVD mortality in CKD patients.METHODS: We used the PCR-CTPP assay method to genotype klotho G395A single nucleotide polymorphism (SNP) in 72 non-dialysis CKD patients. The klotho level was determined using the enzyme-linked immunoassay (ELISA) method. Path analysis was used to determine the relationship between the klotho G395A SNP, plasma klotho level, ASCVD risk score, and CVD mortality risk score.RESULTS: Our results showed that the GA genotype had lower plasma klotho levels than the GG genotype (path coefficient=-0.185, p=0.000). There was a significant negative correlation between plasma klotho level and the ASCVD risk score (r=-0.243, p=0.040), but no significant correlation was found between plasma klotho level and the CVD mortality risk score (r=-0.145, p=0.225). Path analysis showed that plasma klotho level had a significant negative direct effect on ASCVD risk score (path coefficient=-0.272, p=0.000) and an indirect effect on CVD mortality risk score (path coefficient=0.187, p=0.005).CONCLUSION: Klotho G395A SNP might reduce lower plasma klotho levels, which increased ASCVD and CVD mortality risk scores in non-dialysis CKD patients. However, other risk factors such as age, CKD stages, hypertension, and smoking should be taken into consideration. Therefore, large-scale genetic association studies with adjusted variables could be conducted in various ethnic groups for a more robust result.KEYWORDS: klotho, single nucleotide polymorphism, cardiovascular disease, chronic kidney disease

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Correlation between Blood Pressure and Obesity Parameter against Cystatin-C and Adiponectin Levels in Serum of Obese Adolescent

Cited by 4 publications

References 0 publications

Molecular Docking of Citrus amblycarpa Active Compounds against FTO, Leptin, and Resistin Protein

Molecular Docking of Citrus amblycarpa Active Compounds against FTO, Leptin, and Resistin Protein

Ganoderma lucidum Polysaccharide Peptide Reduces Oxidative Stress and Improves Renal Function in Patient with Cardiometabolic Syndrome

The Role of Klotho G395A Gene Polymorphism in Atherosclerotic Cardiovascular Disease and Mortality Risk Scores in Non-dialysis Chronic Kidney Disease

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