Correlation Between CD4+ Counts and Prevalence of Cytomegalovirus Retinitis and Human Immunodeficiency Virus--related Noninfectious Retinal Vasculopathy in Patients With Acquired Immunodeficiency Syndrome

Kuppermann, Baruch D.; Petty, John G.; Richman, Douglas D.; Mathews, W. Christopher; Fullerton, S; Rickman, Leland S.; Freeman, William R.

doi:10.1016/s0002-9394(14)71453-9

Cited by 307 publications

(104 citation statements)

References 27 publications

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“…A principal infecção ocular na AIDS é a retinite por citomegalovirus (CMV) (5) . As doenças oportunistas apresentam, na grande maioria das vezes, quadros clínicos típicos o que possibilita o diagnóstico apenas por meio de exame oftalmológico.…”

Section: I S C U S S ã Ounclassified

Retinopatia associada ao uso de didanosina

Muralha

Reisner

Curi

2001

Arq. Bras. Oftalmol.

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Section: I S C U S S ã Ounclassified

Retinopatia associada ao uso de didanosina

Muralha

Reisner

Curi

2001

Arq. Bras. Oftalmol.

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“…1,2 The most frequent posterior segment disease in patients infected with human immunodeficiency virus (HIV) is HIV retinopathy, an ischemic retinopathy ophthalmoscopically characterized by cotton-wool spots and intraretinal hemorrhages. 3 Pepose and others 4 have shown that in HIV-positive patients the microangiopathy leads to loss of inner retinal structures including the vasculature and ganglion cells and that this is associated with retinal capillary and vascular loss. Cottonwool spots can be seen clinically in these patients and are more common as the immunodeficiency worsens.…”

mentioning

confidence: 98%

Objective analysis of retinal damage in HIV-positive patients in the HAART era using OCT

Kozák

Bartsch

Cheng

et al. 2005

American Journal of Ophthalmology

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PURPOSE-To assess retinal nerve fiber layer (RNFL) thickness in patients with human immunodeficiency virus (HIV) disease without cytomegalovirus retinitis (CMV). DESIGN-A case-control study.METHODS-The study included 113 eyes of 65 patients in one center. Thickness of RNFL along a 3.4-mm-diameter circle centered on the optic nerve head was evaluated using third-generation optical coherence tomography. Patients in group A (39 eyes of 22 patients) were human immunodeficiency virus-negative control subjects. Group B (36 eyes of 18 patients) was composed of HIV patients with no history of CMV retinitis and CD4 counts consistently above 100. Group C (38 eyes of 25 patients) comprised HIV patients with no history of CMV retinitis but a history of CD4 count less than 100 at some point lasting for at least 6 months. RESULTS-The average RNFL thicknesses in groups A, B, and C were 103.33 ± 8.50 μm, 103.30 ± 9.28 μm, and 90.10 ± 12.50 μm, respectively. Group C had significantly thinner overall RNFL than either of the groups A and B (Tukey-Kramer). This difference was most prominent in temporal, superior, and inferior retinal areas. No difference was in nasal retinal area, nor between groups A and B in any of the areas.

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“…This finding is relatively low in comparison to other studies. [31,32] Toxoplasma chorioretinitis was seen only in 2% of patients. It may cause a variety of ocular abnormalities.…”

Section: Discussionmentioning

confidence: 96%

A Study of Ocular Complications of HIV/AIDS in a Teaching Medical College in North-Eastern India

Singh¹,

Singh²

2018

AIMDR

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Background: HIV infection/AIDS is becoming a public health hazard globally. Ocular complications of HIV/AIDS are very common and its severity increases as the disease progresses and ultimately leads to blindness. Objective: The purpose of the present study was to determine the prevalence and type of ocular complications in patients with HIV/AIDS. Methods: A cross-sectional study was done on patients with HIV infection/AIDS who attended or referred to eye OPD and also cases from General Medicine ward of JNIMS. A complete ophthalmic evaluation of both anterior and posterior segments was conducted. HIV sero-positivity was established by ELISA and confirmed by Western Blot in all cases. Results: The majority of the patients were in the age group of 21-40yrs. The prevalence of ocular involvement was 47%. The commonest involvement was on posterior segment with HIV retinopathy and cotton wool spots (20%) and CMV retinitis (5%). Anterior segment involvement was 18% with conjunctival micro-vasculopathy being the commonest (8%) and HZO in 5 cases. Conclusion: HIV infection is fairly common in Manipur among the age group of 20-40yrs., IDU being the commonest route of infection. Ocular involvement occurred in 47% of cases and it may be the first manifestation. So, the ophthalmologist must be aware for prompt treatment and prevention of visual disabilities.

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Correlation Between CD4+ Counts and Prevalence of Cytomegalovirus Retinitis and Human Immunodeficiency Virus--related Noninfectious Retinal Vasculopathy in Patients With Acquired Immunodeficiency Syndrome

Cited by 307 publications

References 27 publications

Retinopatia associada ao uso de didanosina

Retinopatia associada ao uso de didanosina

Objective analysis of retinal damage in HIV-positive patients in the HAART era using OCT

A Study of Ocular Complications of HIV/AIDS in a Teaching Medical College in North-Eastern India

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