Hyaloid adhesion to the macula is associated with AMD, and frequently causes VMT in eyes with CNV. Tractional forces may antagonize the effect of anti-VEGF treatment, and cause pharmacological resistance in a subpopulation of patients. Future studies are needed to define the role of vitreoretinal surgery in such cases. Spectral OCT/SLO allows careful diagnosis and follow-up.

The nonlinear response and strong coupling of control channels in micromachined membrane deformable mirror (MMDM) devices make it difficult for one to control the MMDM to obtain the desired mirror surface shapes. A closed-loop adaptive control algorithm is developed for a continuous-surface MMDM used for aberration compensation. The algorithm iteratively adjusts the control voltages of all electrodes to reduce the variance of the optical wave front measured with a Hartmann-Shack wave-front sensor. Zernike polynomials are used to represent the mirror surface shape as well as the optical wave front. An adaptive experimental system to compensate for the wave-front aberrations of a model eye has been built in which the developed adaptive mirror-control algorithm is used to control a deformable mirror with 19 active channels. The experimental results show that the algorithm can adaptively update control voltages to generate an optimum continuous mirror surface profile, compensating for the aberrations within the operating range of the deformable mirror.

Scanning laser ophthalmoscope microperimetry is able to detect changes in retinal sensitivity in AMD patients overlying drusen and at the margin of GA. It is a useful device to grade focal retinal sensitivity in patients with dry age-related macular degeneration.

Drusen volume as determined by spectral domain-OCT correlates with AREDS-determined drusen area and AREDS grade in nonexudative AMD. The correlation is not perfect, however, because drusen area and volume average 40% and 82% of the variation, respectively. Drusen volume can provide additional information in grading the severity of eyes with dry AMD.