Correlation Between Dry Eye and Rheumatoid Arthritis Activity

Fujita, Miho; Igarashi, Tsutomu; Kurai, Toshiyuki; Sakane, Manabu; Yoshino, Shinichi; Takahashi, Hiroshi

doi:10.1016/j.ajo.2005.05.025

Cited by 109 publications

(88 citation statements)

References 25 publications

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“…10 s), the tear dynamics were considered abnormal; (3) ocular surface abnormalities which were identified by positive vital staining with fluorescein. Patients with positive results in all three criteria were considered to have definite dry eye, whereas patients with abnormalities in only two of the three criteria were defined to have probable dry eye disease [28] . Exclusion criteria for controls and POAG patients were: medical history of disorders associated with increased Hcy levels such as thromboembolic, renal, hepatic, gastrointestinal or neurologic disease, as well as prior ocular surgery, a history of ocular inflammation, age-related macular degeneration, diabetic retinopathy, myopia, retinal occlusive disease, rubeosis iridis and glaucoma other than POAG.…”

Section: Patients and Designmentioning

confidence: 99%

“…21 mm Hg), and normal eye examination, including open angles, normal appearance of the optic disks and normal visual fields. Each patient was evaluated for dry eye syndrome based on three criteria which had been used in previous studies [28,29] : (1) history of, treatment of, or symptoms of dry eye syndrome defined according to the Ocular Surface Disease Index [30] questionnaire; (2) tear dynamics which were assessed by the Schirmer 1 test and tear breakup time; if one of those two tests was positive (Schirmer 1 test ! 10 mm, or breakup time !…”

Section: Patients and Designmentioning

confidence: 99%

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Increased Homocysteine Levels in Tear Fluid of Patients with Primary Open-Angle Glaucoma

et al. 2008

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Aims: We assessed homocysteine (Hcy) levels in tear fluid and plasma of patients with primary open-angle glaucoma (POAG). We determined the association between Hcy levels, dry eye syndrome and B vitamin status. Methods: This prospective case-control study included 36 patients with POAG and 36 controls. Hcy concentrations were measured by high-performance liquid chromatography. Results: Patients with POAG had significantly higher mean Hcy levels both in tear fluid (205 ± 84 nmol/l; p < 0.001, t test) and in plasma (13.43 ± 3.53 µmol/l; p = 0.001, t test) than control subjects (130 ± 53 nmol/l and 10.50 ± 3.33 µmol/l, respectively). Hcy in tear fluid was significantly correlated with plasma Hcy in POAG patients (r = 0.459; p = 0.005, Pearson’s correlation), but not in controls (r = 0.068; p = 0.695). POAG patients with dry eye disease had significantly higher Hcy levels both in tear fluid and plasma than POAG patients without dry eye disease. There was no association between Hcy levels and B vitamin status in subjects with POAG. Conclusions: The study suggests increased Hcy levels in tear fluid and plasma of patients with POAG. Elevated Hcy levels might be a risk factor for POAG and dry eye syndrome in subjects with glaucoma.

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Section: Patients and Designmentioning

confidence: 99%

Section: Patients and Designmentioning

confidence: 99%

Increased Homocysteine Levels in Tear Fluid of Patients with Primary Open-Angle Glaucoma

et al. 2008

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“…To fulfi l criteria for secondary Sjögren's syndrome people should experience, in addition to their connective tissue disease, ocular (or oral) symptoms of dryness with evidence of decreased tear production (or oral equivalent) and have documented histological involvement (Vitali et al, 2002). Fujita et al (2005) evaluated the prevalence of dry eyes among people with RA: 10% of their participants met the criteria for Sjögren's syndrome, but 90% of the people with RA but not Sjögren's syndrome were diagnosed with 'dry eye'. This highlights the different results obtained depending on whether people are classifi ed with 'dry eyes' or histologically confi rmed secondary Sjögren's syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are no published systematic surveys of the prevalence of diverse ocular pathologies and visual impairment among people with RA; previous studies in this population have focused on individual elements of ocular manifestations (e.g. Bhadoria et al, 1989;Fujita et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and predictors of ocular manifestations of RA: is there a need for routine screening?

Piper

Douglas

Treharne

et al. 2007

Musculoskeletal Care

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Visual impairment does not appear to be particularly prevalent in RA, obviating the need for a screening programme. Utilization of the VFQ-25 as a screening tool in RA requires further consideration. The high prevalence of cataracts in participants on steroids emphasizes the need to prescribe the minimum required dose. The high prevalence of dry eyes suggests that a Schirmer's test should be performed regularly, with prescription of artificial tears if required.

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“…Wolfe et al (6) verificaram que a ceratoconjuntivite seca era mais comum em pacientes com artrite mais grave, que tinham sido submetidos a próteses articulares e que tinham maior disfunção para trabalho. Já Fujita et al (7) não encontrou associação entre gravidade de olho seco e atividade da artrite reumatóide mas sim naqueles que preenchiam critérios para Síndrome de Sjögren secundária.…”

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Olho seco e Sjögren secundário na artrite reumatóide

Gehlen¹,

Skare²,

Silva³

et al. 2012

Rev. bras.oftalmol.

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RESUMOObjetivo: Examinar a prevalência de ceratoconjuntivite seca e de Síndrome de Sjögren (SS) secundária em pacientes com AR do sul do Brasil e analisar suas relações com duração e atividade da AR e classe funcional do paciente. Pacientes com artrite reumatóide (AR) podem ter ceratoconjuntivite seca, que é considerada uma manifestação extra-articular dessa doença. Métodos: Estudaram-se 82 pacientes com AR para sintomas de secura, Schirmer teste, DAS-28 ( índice de atividade da AR) e classe funcional. Resultados: Sintomas de secura ocular estavam presentes em 57,3%, Schirmer positivo em 41,2% e SS secundária em 24.3%. A presença de um teste positivo para o Schirmer ou da SS secundária não teve associação com duração de doença (p=0,65 and 0,80), atividade da AR (p=0,42 and 0,25) nem com a classe funcional do paciente (p= 0.84 and 0,79). Conclusão: Existe uma alta prevalência de síndrome sicca nos pacientes com AR; ¼ deles tem SS secundário. O aparecimento de SS secundário e da síndrome sicca é independentes de atividade, tempo de duração e do dano cumulativo gerado pela AR subjacente .Descritores: Olho seco/etiologia; Síndrome de Sjögren/etiologia; Artrite reumatóide/complicações ABSTRACT Objective: To examine the prevalence of keratoconjuntivitis sicca and secondary Sjögren syndrome (SS) in patients with RA from Southern Brazil and to analyze their relationship with RA duration, activity and patient's functional class. Patients with rheumatoid arthritis (RA) may have keratoconjuntivitis sicca that can be considered an extra articular manifestation of this disease. Methods: We studied 82 RA patients for sicca symptoms, Schirmer test, DAS-28 (RA activity index) and functional class. Results: There were eye sicca symptoms in 57.3%, positive Schirmer test in 41.2% and Secondary SS in 24.3%. The presence of a positive Schirmer test or the secondary SS had no relation with disease duration (p=0.65 and 0.80), RA activity (p=0,42 and 0,25) and neither with the patient's functional class (p= 0.84 and 0.79). Conclusion: There is a high prevalence of sicca syndrome in RA patients; one fourth of them have secondary SS. Secondary SS and sicca syndrome occurrence is independent of underlying RA activity, duration and cumulative damage.

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Correlation Between Dry Eye and Rheumatoid Arthritis Activity

Cited by 109 publications

References 25 publications

Increased Homocysteine Levels in Tear Fluid of Patients with Primary Open-Angle Glaucoma

Increased Homocysteine Levels in Tear Fluid of Patients with Primary Open-Angle Glaucoma

Prevalence and predictors of ocular manifestations of RA: is there a need for routine screening?

Olho seco e Sjögren secundário na artrite reumatóide

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