Correlation between Estrogen Levels with Lipid Profile in Menopause Women in West Sumatera

Ariadi, Ariadi; Jamsari, Jamsari; Yanwirasti, Yanwirasti; Siregar, Muhammad Fidel Ganis; Yusrawati, Yusrawati

doi:10.3889/oamjms.2019.627

Cited by 5 publications

(6 citation statements)

References 11 publications

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“…It was found that F. deltoidea restored the levels of total cholesterol, triglycerides, LDL-C, and HDL-C to normal levels in PCOS rats that had improvement in hormonal profile and the estrous cycle. The data support that the relationship between lipid profile and sex hormones [ 49 , 50 ]. These results are also compatible with earlier studies demonstrating that F. deltoidea can reverse the abnormalities in the lipid profile of diabetic rats [ 51 ] and adults with pre-diabetes [ 52 ],…”

Section: Discussionsupporting

confidence: 84%

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Haslan

Samsulrizal

Zin

et al. 2021

BMC Complement Med Ther

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Background Insulin resistance and hormonal imbalances are key features in the pathophysiology of polycystic ovarian syndrome (PCOS). We have previously shown that Ficus deltoidea var. deltoidea Jack (Moraceae) can improve insulin sensitivity and hormonal profile in PCOS female rats. However, biological characteristics underpinning the therapeutic effects of F. deltoidea for treating PCOS remain to be clarified. This study aims to investigate the biochemical, hormonal, and histomorphometric changes in letrozole (LTZ)-induced PCOS female rats following treatment with F. deltoidea. Methods PCOS was induced in rats except for normal control by administering LTZ at 1 mg/kg/day for 21 days. Methanolic extract of F. deltoidea leaf was then orally administered to the PCOS rats at the dose of 250, 500, or 1000 mg/kg/day, respectively for 15 consecutive days. Lipid profile was measured enzymatically in serum. The circulating concentrations of reproductive hormone and antioxidant enzymes were determined by ELISA assays. Ovarian and uterus histomorphometric changes were further observed by hematoxylin and eosin (H&E) staining. Results The results showed that treatment with F. deltoidea at the dose of 500 and 1000 mg/kg/day reduced insulin resistance, obesity indices, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), malondialdehyde (MDA), testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) to near-normal levels in PCOS rats. The levels of high-density lipoprotein cholesterol (HDL), estrogen, and superoxide dismutase (SOD) are also similar to those observed in normal control rats. Histomorphometric measurements confirmed that F. deltoidea increased the corpus luteum number and the endometrial thickness. Conclusions F. deltoidea can reverse PCOS symptoms in female rats by improving insulin sensitivity, antioxidant activities, hormonal imbalance, and histological changes. These findings suggest the potential use of F. deltoidea as an adjuvant agent in the treatment program of PCOS.

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Section: Discussionsupporting

confidence: 84%

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Haslan

Samsulrizal

Zin

et al. 2021

BMC Complement Med Ther

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“…It also increases lipoprotein lipase activity, and lipoprotein lipase is responsible for hydrolyzing TG. 31 In males’, testosterone increases the degradation of HDL molecule by stimulating the expression of genes encoding for hepatic lipase and scavenger receptor B. On the other hand, testosterone reduced the expression of LDL receptors and the activity of lipoprotein lipase.…”

Section: Discussionmentioning

confidence: 99%

“…30 Besides, the reduction of estrogen causes dysregulation of lipoprotein lipase activity and results in to increase in LDL and TC levels. 31 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

GB¹,

Menon²,

Gizaw³

et al. 2022

IJGM

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Introduction H. pylori are gram-negative, microaerophilic helical-shaped bacteria with multiple flagella and commonly exist in the stomach. This infection may cause significant mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ systems external to the gastrointestinal tract. To assess cardiovascular risk factors and to predict cardiovascular disorders, we are evaluating and comparing lipid profile and inflammatory marker between H. pylori- positive and negative patients. Objective To evaluate and compare lipid profile (TC; TG; LDL; HDL) and inflammatory marker (hs-CRP) in dyspeptic patients with and without H. pylori infection. Methods Comparative cross-sectional study was conducted from September 2020 to January 2021 at Debre Markos Referral Hospital, Debre Markos Health Center, and Hidassie Health Center, Ethiopia. Each of 50 H. pylori -positive and negative dyspeptic patients were studied. The data were checked for completeness and analyzed by SPSS version 25.0 Software. A p-value < 0.05 was considered statistically significant. Results Serum mean high-density lipoprotein (HDL) values were 37.54 ± 7.98 mg/dL and 43.12 ± 7.86 mg/dL (p < 0.05) for H. pylori -positive and negative dyspeptic patients, respectively, and median serum high sensitive C reactive protein (hs-CRP) levels were 6.29 mg/L (1.66–41.34) and 3.35 mg/L (0.39–10.01) (p < 0.05) for H. pylori -positive and negative dyspeptic patients, respectively. Conclusion H. pylori infection significantly alters serum high-density lipoprotein (HDL) and high sensitive C reactive protein (hs-CRP) levels in dyspeptic patients, as a result, increase the potential risk of cardiovascular diseases.

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“…Menopause is a time of drastic transition and many hormonal changes in women [ 89 ]. One of the major results of menopause is a marked decrease in estrogen levels [ 90 ]. The post-menopausal levels of triacylglycerols are much higher than the triacylglycerol levels in pre-menopausal woman [ 89 ].…”

Section: Molecular and Cellular Basis Of T2d Pathogenesismentioning

confidence: 99%

The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis

Chapple,

Woodfin,

Moore

2024

Molecules

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Type 2 diabetes (T2D) is a growing health concern with an estimated 462 million people having been diagnosed worldwide. T2D is characterized by chronically elevated blood glucose and insulin resistance, which culminate in a diminished function of the β-cell mass in its later stages. This can be perpetuated by and result in inflammation, excess reactive oxygen species production, obesity, and the dysregulation of multiple cellular pathways. Many naturally occurring small molecules have been investigated in terms of their roles in modulating glucose homeostasis and β-cell function. Many of these compounds can be found in commonly used sources of food and drink. Interestingly, a correlation has been observed between coffee consumption and T2D incidence. However, the specific compounds responsible for this correlation and their mechanisms are still somewhat undetermined. This paper reviews recent research findings on the effects of several polyphenols that are either found in coffee or are metabolites of compounds found in coffee (enterodiol, enterolactone, matairesinol, secoisolariciresinol, kaempferol, quercetin, and chlorogenic acid) on glucose homeostasis and health complications associated with glucose dysregulation, with a special emphasis on their potential anti-diabetic effects. The factors that affect polyphenol content in coffee are also addressed.

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Correlation between Estrogen Levels with Lipid Profile in Menopause Women in West Sumatera

Cited by 5 publications

References 11 publications

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis

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