Correlation between immunological-inflammatory markers and endothelial disfunction in the early stage of coronary heart disease

Peršić, Viktor; Bastiančić, Ana Lanča; Rosovic, Ivan; Raljević, Damir; Samsa, Dijana Travica; Bastiančić, Luka; Miškulin, Rajko; Boban, Marko; Laškarin, Gordana

doi:10.1016/j.mehy.2018.04.001

Cited by 12 publications

(10 citation statements)

References 54 publications

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“…Nonetheless, pro-inflammatory mediators are deeply involved in the initiation and the progression of coronary artery disease (CAD) and can act independently of metabolic risk factors. 98 Back in the late 1980s, 2 prospective trials were performed in male population with prophylactic aims including nutritional interventions in a group of high CVD risk: lowering of the total caloric intake, consumption of food cholesterol and refined sugar, as well as rise of animal protein, poly-unsaturated fatty acid (PUFA) and monounsaturated fatty acid (MUFA), and complex carbohydrates consumption. After 3 years of follow-up, these interventions resulted in reduction of risk factors for coronary disease, mostly on the drop of blood plasma cholesterol and the decrease of arterial pressure provided by weight reduction.…”

Section: Nrs In Ischemic Heart Diseasementioning

confidence: 99%

Nutritional Considerations of Cardiovascular Diseases and Treatments

Boban

Bulj

Zeljković³

et al. 2019

Nutr Metab Insights

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Nutritional considerations of many chronic diseases are not fully understood or taken into consideration in everyday clinical practice. Therefore, it is not surprising that high proportion of hospitalized patients with cardiovascular diseases remains underdiagnosed with malnutrition. Malnourished patients have increased risk of poor clinical outcomes, complications rate, prolonged hospital stay, more frequent rehospitalizations, and lower quality of life. The purpose of this review is to recapitulate recent data on nutritional considerations in cardiovascular medicine.

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Section: Nrs In Ischemic Heart Diseasementioning

confidence: 99%

Nutritional Considerations of Cardiovascular Diseases and Treatments

Boban

Bulj

Zeljković³

et al. 2019

Nutr Metab Insights

Self Cite

View full text Add to dashboard Cite

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“…[8]. При различных патологических состояниях ММП являются составляющей неспецифического воспалительного ответа [9]. Естественными ингибиторами ММП in vivo служат тканевые ингибиторы металлопротеиназ (TIMP) и α 2 -макроглобулин.…”

Section: Information About the Corresponding Authorunclassified

“…Показано, что действие ММП на сосудистый тонус обусловлено не только относительно медленными процессами ремоделирования сосудистой стенки, но и более быстрыми воздействиями, которые направлены, главным образом, на эндотелий и миоциты сосудистой стенки. Причем данный механизм опосредован другими путями, отличными от NO-или циклооксигеназного путей [9].…”

Section: Information About the Corresponding Authorunclassified

“…Следует отметить, что ММП-9 оказалась единственным чувствительным маркером ИБС, в то время как интерлейкины (IL-2 и IL-6) не продемонстрировали статистически значимой разницы между двумя группами. Результаты аналогичных исследований, в которых определялся и сравнивался уровень только ММП-9 у пациентов с мягкими, т. е. более подверженными повреждению, бляшками, и у пациентов с более стабильными бляшками [9,17], нельзя трактовать однозначно в связи с отсутствием определения TIMP-1. Таким образом, определение уровня только ММП-9 без TIMP-1 является лимитирующим фактором в интерпретации результатов многих проведенных исследований.…”

Section: Information About the Corresponding Authorunclassified

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Markers of Vascular Wall Fibrosis Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinases-1 in Patients with Ischemic Heart Disease with and without Concomitant Type-2 Diabetes Mellitus

et al. 2019

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The prevalence of ischemic heart disease (IHD) and diabetes mellitus type 2 (DM type 2) is permanently increasing both worldwide and in theRussian Federation. That is why studies of mechanisms of pathogenesis of both diseases is continuing for prevention of complications and mortality. DM type 2 contributes a lot to deterioration of IHD. One of pathogenetic features these two pathologies share is pronounced blood vessel wall fibrosis. In this review we present analysis of studies devoted to the determination of the role of metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 indevelopment of vascular wall fibrosis.

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“…Одним из маркеров, связанных с изменением продукции NO, является ген эндотелиальной синтазы оксида азота 3-го типа (NOS3) [9,10]. Также происходят изменения секреции и ряда других веществ, отвечающих за поддержание нормального функционирования сосудистого эндотелия [11,12]. При этом главной проблемой изучения состояния сосудистого эндотелия является отсутствие универсального метода и стандартов проведения исследований.…”

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Association of genetic, biochemical and functional markers of the condition of the vascular endothelium in chronic heart failure with mid-range ejection fraction

2019

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The aim of this study was to analyse genetic (polymorphism 4a/4b gene NOS3), biochemical (endothelin-1) and functional (endothelial function coefficient) markers of a condition of vascular endothelium in patients (n = 65) with chronic heart failure (CHF) with mid-range ejection fraction (40–49%), depending of the stage of the disease and identify the presence of associations between the analyzed markers. Somatically healthy people (n = 65) were examined as a control group. A decrease in the value of the endothelial function coefficient and an increase in the production of endothelin-1 in all groups of patients compared with somatically healthy people were revealed. The severity of these changes was greater in groups of patients with more severe stage of the disease. The analysis of polymorphism 4a/4b gene NOS3 in patients with CHF revealed a statistically significant predominance of the number of patients with a more severe stage of the disease among of patients with polymorphism 4a/4b. Patients with polymorphism 4a/4b had a statistically significant lower value of the endothelial function coefficient and a higher level of endothelin-1 compared patients with polymorphism 4b/4b. Thus, polymorphism 4a/4b is characterized by a deeper lesion of the vascular endothelium in patients with CHF with mid-range ejection fraction and the development of more severe stages of the disease. The obtained data can be used in the aspect of personalized medicine.

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Correlation between immunological-inflammatory markers and endothelial disfunction in the early stage of coronary heart disease

Cited by 12 publications

References 54 publications

Nutritional Considerations of Cardiovascular Diseases and Treatments

Nutritional Considerations of Cardiovascular Diseases and Treatments

Markers of Vascular Wall Fibrosis Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinases-1 in Patients with Ischemic Heart Disease with and without Concomitant Type-2 Diabetes Mellitus

Association of genetic, biochemical and functional markers of the condition of the vascular endothelium in chronic heart failure with mid-range ejection fraction

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