Correlation between postprandial bile acids and body fat mass in healthy normal-weight subjects

Suzuki, Tatsuya; Aoyama, Junya; Hashimoto, Masao; Ohara, Makoto; Futami-Suda, Shoko; Suzuki, Kazunari; Ouchi, Motoshi; Igari, Yoshimasa; Watanabe, Kentaro; Nakano, Hiroshi

doi:10.1016/j.clinbiochem.2014.04.025

Cited by 15 publications

(9 citation statements)

References 15 publications

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“…DCA administration increased serum DCA levels by 3-fold ( Figure 2E). It has been reported that 1.5-2 hours after taking a regular or high-fat meal, the serum total bile acid and DCA levels increase 4-and 6-fold, respectively (19,20). These levels are within the range we observed after intra-arterial infusion of DCA.…”

Section: Resultssupporting

confidence: 84%

“…Our studies showed that DCA (10 μg/kg, iv) administration increased serum DCA level to 2.5 μmol/L, which is similar to the levels observed after high-fat feeding (Figure 2E). These levels are in the range reported after a high-fat meal in humans (19,20), suggesting that the doses of DCA used in our studies are within physiological levels. The vagus nerve innervates the gastrointestinal tract as distal as the midtransverse colon.…”

Section: Discussionsupporting

confidence: 68%

See 1 more Smart Citation

Satiety induced by bile acids is mediated via vagal afferent pathways

Wu¹,

Li²,

Lee³

et al. 2020

JCI Insight

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Section: Resultssupporting

confidence: 84%

Section: Discussionsupporting

confidence: 68%

Satiety induced by bile acids is mediated via vagal afferent pathways

Wu¹,

Li²,

Lee³

et al. 2020

JCI Insight

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“…In this population no associations between plasma bile acids and different parameters of body composition, as assessed non-invasively by bioelectrical impedance analysis, were observed. In light of the positive association of bile acids with BMI observed in the present study, a recent study surprisingly described a negative association of body fat mass and bile acids in healthy normal weight subjects (Suzuki et al, 2014 ). These differences may be due to the investigation of fasting bile acid levels in the present vs. postprandial concentrations in the study of Suzuki and colleagues (Suzuki et al, 2014 ).…”

Section: Discussionsupporting

confidence: 51%

“…In light of the positive association of bile acids with BMI observed in the present study, a recent study surprisingly described a negative association of body fat mass and bile acids in healthy normal weight subjects (Suzuki et al, 2014 ). These differences may be due to the investigation of fasting bile acid levels in the present vs. postprandial concentrations in the study of Suzuki and colleagues (Suzuki et al, 2014 ). Moreover, one has to keep in mind that the population of anorexic subjects might have too low amounts of body fat to study possible associations.…”

Section: Discussionsupporting

confidence: 51%

Plasma bile acids show a positive correlation with body mass index and are negatively associated with cognitive restraint of eating in obese patients

et al. 2015

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Bile acids may be involved in the regulation of food intake and energy metabolism. The aim of the study was to investigate the association of plasma bile acids with body mass index (BMI) and the possible involvement of circulating bile acids in the modulation of physical activity and eating behavior. Blood was obtained in a group of hospitalized patients with normal weight (BMI 18.5–25 kg/m2), underweight (anorexia nervosa, BMI < 17.5 kg/m2) and overweight (obesity with BMI 30–40, 40–50 and >50 kg/m2, n = 14–15/group) and plasma bile acid concentrations assessed. Physical activity and plasma bile acids were measured in a group of patients with anorexia nervosa (BMI 14.6 ± 0.3 kg/m2, n = 43). Lastly, in a population of obese patients (BMI 48.5 ± 0.9 kg/m2, n = 85), psychometric parameters related to disordered eating and plasma bile acids were assessed. Plasma bile acids showed a positive correlation with BMI (r = 0.26, p = 0.03) in the population of patients with broad range of BMI (9–85 kg/m2, n = 74). No associations were observed between plasma bile acids and different parameters of physical activity in anorexic patients (p > 0.05). Plasma bile acids were negatively correlated with cognitive restraint of eating (r = −0.30, p = 0.008), while no associations were observed with other psychometric eating behavior-related parameters (p > 0.05) in obese patients. In conclusion, these data may point toward a role of bile acids in the regulation of body weight. Since plasma bile acids are negatively correlated with the cognitive restraint of eating in obese patients, this may represent a compensatory adaptation to prevent further overeating.

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“…Insulin resistance and Type 2 Diabetes Mellitus, moreover, have been linked to an increased fasting plasma concentration in combination with shifts of the conjugation and composition of plasma bile acids ( Haeusler et al, 2013 ; Wewalka et al, 2014 ; Sonne et al, 2016 ). The postprandial response of plasma bile acids is also implicated in metabolic disease, as it is blunted in obesity ( Suzuki et al, 2014 ; Haeusler et al, 2016 ), but amplified following bariatric surgery ( Cole et al, 2015 ; Penney et al, 2015 ). However, the role bile acids play in these cases remains unclear.…”

Section: Introductionmentioning

confidence: 99%

In Silico Analysis Identifies Intestinal Transit as a Key Determinant of Systemic Bile Acid Metabolism

et al. 2018

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Bile acids fulfill a variety of metabolic functions including regulation of glucose and lipid metabolism. Since changes of bile acid metabolism accompany obesity, Type 2 Diabetes Mellitus and bariatric surgery, there is great interest in their role in metabolic health. Here, we developed a mathematical model of systemic bile acid metabolism, and subsequently performed in silico analyses to gain quantitative insight into the factors determining plasma bile acid measurements. Intestinal transit was found to have a surprisingly central role in plasma bile acid appearance, as was evidenced by both the necessity of detailed intestinal transit functions for a physiological description of bile acid metabolism as well as the importance of the intestinal transit parameters in determining plasma measurements. The central role of intestinal transit is further highlighted by the dependency of the early phase of the dynamic response of plasma bile acids after a meal to intestinal propulsion.

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Correlation between postprandial bile acids and body fat mass in healthy normal-weight subjects

Cited by 15 publications

References 15 publications

Satiety induced by bile acids is mediated via vagal afferent pathways

Satiety induced by bile acids is mediated via vagal afferent pathways

Plasma bile acids show a positive correlation with body mass index and are negatively associated with cognitive restraint of eating in obese patients

In Silico Analysis Identifies Intestinal Transit as a Key Determinant of Systemic Bile Acid Metabolism

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