Correlation between second trimester beta human chorionic gonadotropin levels and pregnancy outcome in high risk group

Sharma, Praveen; Maheshwari, Sunita; Barala, Shivani

doi:10.18203/2320-1770.ijrcog20162127

Cited by 5 publications

(7 citation statements)

References 4 publications

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“…1,2,3 Although overt PIH rarely appears until third trimester, there are many studies which show that the disease begins early in pregnancy. The underlying patho-physiological mechanism responsible for the disease process seems to appear between 8 to 18 weeks of gestation which makes it logical to search for predictive indicators.…”

Section: Introductionmentioning

confidence: 99%

Utility of second trimester beta HCG levels in prediction of gestational hypertension: a prospective cohort study

Chowdhary

Khurshid

Parveen

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Gestational hypertension is a significant threat both to maternal and fetal health. However, it is still a distant dream to predict accurately its occurrence in early pregnancy. Objective was to find out if β HCG levels determined between 13 to 20 weeks of gestation can be used as a predictor for gestational hypertension.Methods: This prospective observational cohort study was conducted from August 2014 to January 2016. Serum β HCG levels were determined at 13 to 20 weeks of gestation of 190 normotensive pregnant women attending the antenatal clinics. They were followed for the development of gestational hypertension till 40 weeks of gestation or delivery.Results: Out of the total 190 women, 25 (13.1%) developed gestation hypertension. Of those who developed gestational hypertension, 22 (88%) were having β HCG levels >2 MOM (p<0.001). Absolute β HCG levels (Mean±SD) were also significantly higher (54907±29509 V/S 41095±19103; p<0.001) in subjects who later developed gestational hypertension. Sensitivity, specificity, positive predictive value and the negative predictive value for β HCG at >2 MOM were 83.3, 96.9, 80.0 and 97.5 respectively (95% CI).Conclusions: Pregnant women with high Beta HCG levels in early pregnancy have significantly higher risk for development of gestational hypertension.

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Section: Introductionmentioning

confidence: 99%

Utility of second trimester beta HCG levels in prediction of gestational hypertension: a prospective cohort study

Chowdhary

Khurshid

Parveen

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…-hCG The obtained result showed that maternal serum level of β-hCG in PIH women was significantly higher (P<0.05), (9601.43 ± 78.71 miu/ml) than positive and negative control groups (4344.50 ± 423.93 miu/ml and 8.83 ± 4.64 miu/ml respectively) as shown in Table- Many studies also has been demonstrated that maternal serum concentrations of beta human chorionic gonadotropin (β-hCG) were significantly rising in the PIH women [19][20][21]. Although the regulation mechanism of gestational hCG remains largely unknown, it is mostly established that syncytiotrophoblast is secreted β-hCG.…”

Section: Resultsmentioning

confidence: 81%

Study the correlation between Human Chorionic Gonadotropin Hormone and Some Biochemical Parameters in Iraqi Women with Pregnancy-Induced Hypertension

Bayram

Salih

Eleiwe

2018

ijs

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Pregnancy-induced hypertension (PIH) is a major pregnancy complication that causes pregnant women mortality. Here, we had scrutinized the correlation between serum levels of -hCG and biochemical parameters in PIH. Serum samples were collected from eighty Iraqi women (forty women with pregnancy-induced hypertension as patients group, twenty normotensive pregnant women as a positive control, and twenty normotensive non-pregnant women as a negative control) all groups were diagnosed clinically. All -hCG hormone level was measured for all studied groups, also serum uric acid, albumin, and total protein levels were measured as biochemical parameters. Data analysis showed that serum level of -hCG hormone was significant increase (p≤0.05) in PIH in compared to control groups. Also Uric acid level was increased significantly in PIH group in compared with control groups. While Albumin show there was no significant difference in PIH group. Total serum protein level was measured by Bradford total Protein assay all results was in normal value and showed a significant difference in PIH group in comparison to control groups. Our study shows that there is correlation between β-hCG with uric acid and albumin levels in PIH. Serial estimation of serum β-hCG, uric acid, and albumin can be important to use as a marker of disease and also can be used in better early management of established cases that lead to preeclampsia and eclampsia.

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“…Pre-eclampsia is a pregnancy specific disorder characterized by newly onset of blood pressure more than 140/90 mmHg, in at least two consecutive occasion and proteinuria (> 300 mg per 24 hours collection) after 20 weeks of pregnancy gestational hypertension is a major pregnancy complication associated with significant fetal risks and maternal morbidity and mortality. [1][2][3] It is responsible 25% of all fetal growth retardation and 15% preterm birth in developed countries. The incidence of pre-eclampsia in India is about 8-10% and maternal mortality due to be reported 8%.…”

Section: Introductionmentioning

confidence: 99%

“…Many etiological (genetic, nutritional, immunological and infectious) and pathophysiological (abnormal placentation, oxidative stress and endothelialdysfunction) pathways have been proposed as causal hypotheses for pre-eclampsia. 1,4 Hypertension in pregnancy is one the most common ailments encountered during pregnancy, complicating 10-15% of pregnancies WHO reviews hypertensive disorders of pregnancy causes 16% of maternal mortality (greater than hemorrhage 13%, abortion 8%, sepsis 2%).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the variations and potential clinical use of second trimester serum markers for the detection of pre-eclampsia

Gautam

Kaur

Chaudhary

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: In many areas of world, hypertensive disease in pregnancy is the single most common cause of maternal death. Pregnancy associated hypertension remains unsolved despite decades of intensive research and remains the most significant problem in obstetrics. The aim of present study is to evaluate the variations and potential clinical use of second trimester serum markers for the detection of pre-eclampsia.Methods: In an observational study, estimations of serum of human chorionic gonadotropin (β-hCG) were done in 347 randomly selected women at 13-20 weeks of gestation in august 2015 to may 2016. Multiple of median (MOM) was calculated from charts of norms available for that weeks of pregnancy. The subjects were followed up till delivery for the development of hypertension in pregnancy and results analysed statistically with Chi-square test.Results: Out of 347, 47 women developed hypertyension and 2MOM of β hCG was significantly (P<0.001) elevated in those who developed hypertension compared to normotensive women. In our study group a significant associations between elevations in second trimester β-hCG and development of hypertension was observed. Thus with second trimester serum marker study, prediction of pre- eclampsia is possible at incipient stage and adverse pregnancy outcome can be minimized.Conclusions: Maternal serum β-hCG level was found to be significantly higher in hypertensive group than normal group.

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Correlation between second trimester beta human chorionic gonadotropin levels and pregnancy outcome in high risk group

Cited by 5 publications

References 4 publications

Utility of second trimester beta HCG levels in prediction of gestational hypertension: a prospective cohort study

Utility of second trimester beta HCG levels in prediction of gestational hypertension: a prospective cohort study

Study the correlation between Human Chorionic Gonadotropin Hormone and Some Biochemical Parameters in Iraqi Women with Pregnancy-Induced Hypertension

Evaluation of the variations and potential clinical use of second trimester serum markers for the detection of pre-eclampsia

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