Correlation between slow-wave myoelectric signals and mechanical contractions in the gastrointestinal tract: Advanced electromyographic method in rats

Szűcs, Kálmán Ferenc; Nagy, A; Grosz, György; Tiszai, Zita; Gáspár, Róbert

doi:10.1016/j.vascn.2016.07.005

Cited by 11 publications

(17 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous study, we found that the myoelectric spectrum of the cecum can be detected below 3 cpm (9). It means that the myoelectric signals of the pregnant uterus and cecum overlap.…”

Section: Discussionmentioning

confidence: 97%

“…It is known that the cecum and pregnant myometrium have different responses to drugs. Cecum is much more sensitive to neostigmine (contraction) and atropine (relaxation), while the pregnant uterus has a very intensive response to oxytocin (contraction) and terbutaline (relaxation) (9,14,15). We found that drugs acting on myometrial activity altered the PsD max with a good correlation to myometrial mechanical contractions, but they did not affect cecal activity.…”

Section: Discussionmentioning

confidence: 99%

“…The myoelectric signals were recorded with the above-mentioned equipment. The analysis and filtering (0-3 cpm) of the signals were carried out as it was described in our previous study (9). …”

Section: Methodsmentioning

confidence: 99%

“…The GI slow-wave signals are well characterized. The stomach, ileum and cecum have different mechanical and myoelectric activities, which are well distinguishable from each other (9). The different myoelectric frequencies of the GI tract segments suggest differences in pacemaker activity and propagation velocity of the ICCs network; however, we have no data about the uterine activity.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Identification of myoelectric signals of pregnant rat uterus: new method to detect myometrial contraction

et al. 2017

Self Cite

View full text Add to dashboard Cite

AimTo develop an electromyography method for pregnant rat uterus in vivo and to separate myometrial signals from the gastrointestinal tract signals.MethodsPregnant Sprague-Dawley rats (n = 8) were anaesthetized and their stomach, small intestine, and large intestine were removed from the abdomen. A pair of thread electrodes was inserted into the uterus, while a pair of disk electrodes was placed subcutaneously above the myometrium. Additionally, a strain gauge sensor was fixed on the surface of the myometrium and cecum for the parallel detection of mechanical contractions in rats (n = 18) with intact gastrointestinal tract. The filtered electric signals were amplified and recorded by an online computer system and analyzed by fast Fourier transformation. The frequency of the electric activity was characterized by cycle per minute (cpm), the magnitude of the activity was described as power spectrum density maximum (PsDmax).ResultsThe frequency of the pregnant uterine activity was 1-3 cpm, which falls within the same range as that of cecum. Measuring by both electrodes, oxytocin (1 µg/kg) increased and terbutaline (50 µg/kg) decreased the PsDmax by 25%-50% (P < 0.001) and 25%-40% (P < 0.01), respectively. We found a strong positive correlation between the alterations of PsDmax values and the strain gauge sensor-detected mechanical contractions (area under curve). The GI specific compounds (neostigmine, atropine) mainly affected the cecal activity, while myometrium specific drugs (oxytocin, terbutaline) influenced the myometrial signals only.ConclusionOur method proved to be able to detect the myoelectric activity that reflects the mechanical contraction. The overlapping myometrial and cecal signals are not separable, but they can be distinguished based on the much higher activity and different pharmacological reactivity of the pregnant uterus. Thus, the early signs of contractions can be detected and labor may be predicted in a fast and sensitive way.

show abstract

“…In our previous study, we found that the myoelectric spectrum of the cecum can be detected below 3 cpm (9). It means that the myoelectric signals of the pregnant uterus and cecum overlap.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Identification of myoelectric signals of pregnant rat uterus: new method to detect myometrial contraction

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although the pregnant uterine and cecal smooth muscle signals are overlapping, the myometrial activity is predominant in late pregnancy, while cecal signals are much more robust in nonpregnant animals. In pregnant animals the different pharmacological relativity of the uterus and the large intestine was also clearly detectable by EMG [11,12].…”

Section: Introductionmentioning

confidence: 86%

Detection of stress and the effects of central nervous system depressants by gastrointestinal smooth muscle electromyography in wakeful rats

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Non-genomic uterorelaxant actions of corticosteroid hormones in rats: An in vitro and in vivo study

Mirdamadi

Schaffer²,

Barna³

et al. 2022

European Journal of Pharmacology

Self Cite

View full text Add to dashboard Cite

Correlation between slow-wave myoelectric signals and mechanical contractions in the gastrointestinal tract: Advanced electromyographic method in rats

Cited by 11 publications

References 24 publications

Identification of myoelectric signals of pregnant rat uterus: new method to detect myometrial contraction

Identification of myoelectric signals of pregnant rat uterus: new method to detect myometrial contraction

Detection of stress and the effects of central nervous system depressants by gastrointestinal smooth muscle electromyography in wakeful rats

Non-genomic uterorelaxant actions of corticosteroid hormones in rats: An in vitro and in vivo study

Contact Info

Product

Resources

About