Correlation of adenosine deaminase activity with cell surface markers in acute lymphoblastic leukemia.

Smyth, John F.; Poplack, David G.; Holiman, Betty J.; Leventhal, Brigid G.; Yarbro, Geraldine Konior

doi:10.1172/jci109179

Cited by 126 publications

(25 citation statements)

References 16 publications

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“…It will be fur thermore important to check the possibility for a new approach to the therapy with Ara-C of CLL and MM. With our results we cannot decide whether the measurement of ADA activity in lymphoblasts offers a method of distinguishing between immuno logical subtypes and the remission in acute lymphocytic leukaemia [12,16,19]. The high values of ADA activity in a progressive stage of AML and a blastic crisis of chronic ML might be of diagnostic help in this dis ease.…”

Section: Discussionmentioning

confidence: 76%

“…The high values of ADA activity in a progressive stage of AML and a blastic crisis of chronic ML might be of diagnostic help in this dis ease. The use of such a potent inhibitor of ADA as 2'-deoxycoformycin [3] may pro vide a new approach to the therapy of T cell acute lymphocytic leukaemia, AML and chronic myelogenous leukaemia [16]. The de creased ADA activity in patients with SLE, treated which immunosuppressive drugs, is in contrast to observations of Zajaczkowski et al [19] who found increased ADA activity in an immunosuppressive treated renal transplantation group.…”

Section: Discussionmentioning

confidence: 99%

“…ADA ac tivity is markedly increased in blast cells of patients with acute lymphocytic leukaemia [12,16] and acute myelogenous leukaemia (AML) [12] but normal to moderately in creased in both leukaemias in remission as long as they were treated with cytostatic drugs [19]. In contrast to the severe com bined immunodeficiency, increased ADA activity was found in patients treated with immunosuppressive drugs [19].…”

Section: Introductionmentioning

confidence: 99%

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Adenosine Deaminase Activity in Plasma and Blood Cells of Patients with Haematological and Autoimmune Diseases

Storch

Krüger

Rotzsch³

1981

Acta Haematol

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Adenosine deaminase (ADA) has been assayed in plasma, erythrocytes, and lymphocytes from 29 patients with haematological and autoimmune diseases. ADA activity was uniformly low in erythrocytes and lymphocytes from patients with non-Hodgkin lymphoma and multiple myeloma (p < 0.001). High levels of ADA activity was found in plasma, erythrocytes, and lymphocytes from patients with myeloid leukemia (p < 0.001). ADA was high in plasma but low in erythrocytes and lymphocytes from patients with autoimmune diseases treated with immunosuppressive drugs (p < 0.05). 4 adults with congenital immunodeficiency showed decreased ADA activity. In the control group of normal blood donors we found a 34-year-old female with low ADA activity in plasma, erythrocytes, and lymphocytes without any immunological abnormalities. This is the 3rd case of a healthy individual deficient for ADA. 1 patient with Osier’s disease and high ADA activity in erythrocytes showed the importance of the purine salvage enzyme not only in lymphocytes.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adenosine Deaminase Activity in Plasma and Blood Cells of Patients with Haematological and Autoimmune Diseases

Storch

Krüger

Rotzsch³

1981

Acta Haematol

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“…Abnormalities of ADA activ ity have been reported in association with immune dysfunction, acute leukaemia, hereditary haemolytic anaemia and re cently with congenital hypoplastic anaemia of Diamond and Blackfan [1][2][3][4]. Furthermore, a 45-70-fold increase of ADA activity associated with decreased intracellular ATP content and haemolytic disorders were found in a patient and other family members carrying the muta tion described by Valentine et al [3].…”

Section: Introductionmentioning

confidence: 89%

Increased Erythrocyte Adenosine Deaminase Activity without Haemolytic Anaemia

et al. 1986

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A 4-fold increase of red blood cell adenosine deaminase (ADA) activity was found in a patient without haemolytic anaemia, but with mild anisopoikilocytosis. High-performance liquid chromatography showed a 40% reduction of adenosine-5’-triphosphate (ATP) while all the other nucleotides were in normal ranges. The patient’s parents (first cousins) and a brother displayed the same enzyme activities as the controls. This observation suggests that mild increases of ADA activity is neither a marker for congenital hypoplastic anaemia as previously reported nor associated with haemolytic anaemia.

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“…Studies with the Friend erythroleukemia cell line, for example, have shown that cellular maturation can be promoted by purine bases or purine analogues (hypoxanthine [Hx], 6-thioguanine, and 6-mercaptopurine) which inhibit NTD biosynthesis (10,11). It has also been observed that lymphoblastic, mono-and myeloblastic leukemia cells express abnormal activity levels of enzymes that regulate the intermediary metabolism of purine NTD, such as adenosine deaminase (12)(13)(14)(15), inosine monophosphate dehydrogenase (IMPD) (16), and 5'-methyl thioadenosine phosphorylase (17).…”

Section: Abstract In Studies With the Human Promyelocyticmentioning

confidence: 99%

Purine metabolism in myeloid precursor cells during maturation. Studies with the HL-60 cell line.

Lucas¹,

Webster²,

Wright³

1983

J. Clin. Invest.

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A B S T R A C T In studies with the human promyelocytic leukemia cell line HL-60, we defined changes in intermediary purine metabolism that appear to contribute to the regulation of terminal maturation in myeloid cells. When HL-60 cells were exposed to compounds that induce maturation, consistent alterations in purine metabolism were found to occur within 24 h of culture.Perturbation of guanosine nucleotide synthesis and decreases of up to 50% in intracellular guanylate pool sizes were associated with the induced maturation of these cells in response to diverse inducing agents. While immature HL-60 cells were observed to synthesize purine nucleotides by both de novo and salvage pathways, the activity of both pathways decreased in cells induced to mature, although the relative contribution of purine salvage increased. Moreover, incorporation of the sal-

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Correlation of adenosine deaminase activity with cell surface markers in acute lymphoblastic leukemia.

Cited by 126 publications

References 16 publications

Adenosine Deaminase Activity in Plasma and Blood Cells of Patients with Haematological and Autoimmune Diseases

Adenosine Deaminase Activity in Plasma and Blood Cells of Patients with Haematological and Autoimmune Diseases

Increased Erythrocyte Adenosine Deaminase Activity without Haemolytic Anaemia

Purine metabolism in myeloid precursor cells during maturation. Studies with the HL-60 cell line.

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