Correlation of clinical and biochemical hyperandrogenism in <scp>Thai</scp> women with polycystic ovary syndrome

Leerasiri, Pichai; Wongwananuruk, Thanyarat; Indhavivadhana, Suchada; Techatraisak, Kitirat; Rattanachaiyanont, Manee; Angsuwathana, Surasak

doi:10.1111/jog.12945

Cited by 16 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was in accordance with the study done on Thai women. 32 The occurance of obesity was 10.1 % in present study. This was 28% in the Chinese study.…”

Section: Discussionsupporting

confidence: 45%

Clinical, ultrasonographical and hormonal correlation in women with polycystic ovarian syndrome

Sidhmalswamy

Ghongdemath²,

Venkatesh

2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of fertile age. The prevalence, time of onset and severity of clinical presentation vary among different ethnic and racial groups. Though there is significant reproductive, endocrine and metabolic morbidity of PCOS, very little is known about its different modes of presentation in Indian population. A cross sectional observational study. The objective To study the correlation between the clinical, ultrasonographical and hormonal features in women diagnosed as PCOS based on the revised diagnostic criteria, 2003.Methods: A cross-sectional study of 74 PCOS women who had oligo ovulatory cycles and polycystic ovarian morphology on ultrasound was done. Data about menstrual history and anthropometric measurements were collected. Clinical observations of acne and hirsutism were made. Transvaginal ultrasonography and biochemical analysis for free testosterone was done.Results: In all, 74 PCOS women were studied and analyzed. The mean age was 24.884.03, mean BMI was 25.48 ±3.75 and mean free testosterone was 3.81±4.05. Among the PCOS women 39.8% were hirsute, 10.1% were obese, 2.3% had acne and 38% were hyperandrogenemic. Of the hyperandrogenemic women 61.2% were hirsute, 53.22% were obese and 36.54% had acne. The association between BMI and free testosterone level was statistically significant (p=0.0023). BMI was moderately correlated with hyperandrogenemia (r=0.446). The mean left ovarian volume was higher in obese than in non-obese women, which was statistically significant (p=0.003). The mean left ovarian volume was high in hyperandrogenemic women which was statistically significant (p=0.00034).Conclusions: In the present study it was found that there is association between obesity and free testosterone level which was significant. There was statistically significant association between ovarian volume and obesity. Similarly, there was association between ovarian volume and hyperandrogenemia which was significant. Hirsutism and acne had no association with hyperandrogenemia.

show abstract

“…This was in accordance with the study done on Thai women. 32 The occurance of obesity was 10.1 % in present study. This was 28% in the Chinese study.…”

Section: Discussionsupporting

confidence: 45%

Clinical, ultrasonographical and hormonal correlation in women with polycystic ovarian syndrome

Sidhmalswamy

Ghongdemath²,

Venkatesh

2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Clinical hyperandrogenism has been shown to correlate poorly with biochemical hyperandrogenism 16 , though is helpful in the diagnosis of PCOS, and may differ ethnically 17 . Clinical and biochemical phenotype are also genetically determined.…”

Section: Discussionmentioning

confidence: 99%

Salivary testosterone measurement in women with and without polycystic ovary syndrome

Sathyapalan

Al-Qaissi

Dargham

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria. Serum and salivary androgen measurements were determined by LC-MS/MS. salT and salA were significantly elevated in PCOS compared to controls (P < 001). No androgen marker was more predictive than another using ROC curves, but multiple logistic regression suggested salT was more predictive than free androgen index (FAI) (p < 0.01). The combination of salT or FAI identified 100% of PCOS women. PCOS women with both biochemical and clinical hyperandrogenism as opposed to clinical hyperandrogenism alone showed a metabolic phenotype (p < 0.05) and insulin resistance (p < 0.001). PCOS patients with an isolated elevated FAI showed increased insulin resistance compared to those with an isolated salT (P < 0.05). salT appeared to be at least as predictive as FAI for the diagnosis of the classical PCOS phenotype, and the combination of salT or FAI identified 100% of PCOS patients. This suggests that salT measurement by LC-MS/MS holds the promise of complementing existing laboratory tests as a means of assessing hyperandrogenemia.

show abstract

“…Asian women tend to be less hirsute than Caucasian women, despite the elevated levels of androgen 26 . A number of controversies regarding the extent of testosterone level and FTI in predicting the severity of hirsutism have prevailed upon earlier studies 6, 27 . Pathophysiologically, androgens play important role in the growth of terminal hair on several predilection areas which are normally hairy for men, but not for women 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Hyperandrogenism, as one of the three diagnostic criteria of PCOS, can be identified with physical examination and laboratory evaluation. Hirsutism is the most frequently found clinical manifestation of hyperandrogenism, accounting for approximately 70–80% of all PCOS cases 3, 6, 7 . The modified Ferriman-Gallwey Score (mFGS) is used to measure the degree of terminal hair growth in several body sites and total score of ≥ 8 is considered hirsutism 8 .…”

Section: Introductionmentioning

confidence: 99%

Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS

et al. 2019

View full text Add to dashboard Cite

Background: Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, affecting 5-20% of women worldwide. Hyperandrogenism, as the primary characteristic of PCOS, is not always present in every patient. The hyperandrogenic phenotype of PCOS patients is influenced by both hormonal and metabolic dysfunctions. Therefore, this study aims to determine the correlation between hormone profile, lipid profile, and clinical profile with free testosterone index in subjects with PCOS. Methods: This prospective cross-sectional study was conducted in the Dr. Cipto Mangunkusumo General Hospital between July 2014 and December 2016. The study involved 76 women with PCOS, who were classified into 2 subgroups: 39 subjects in the hyperandrogenism group and 37 subjects in the non-hyperandrogenism group. Each subject underwent physical examination, blood sample collection, and USG examination. Bivariate analysis was done using independent t-tests and Mann Whitney U-tests, while multivariate analysis was done using logistic regression. Results: Triglyceride and testosterone level showed weak (r = 0.232, p = 0.044) and moderate (r = 0.460, p ¡ 0.001) positive correlation with FTI, while SHBG level showed moderate negative correlation (r = -0.483, p ¡ 0.001). Triglyceride was also found to be determinant of hyperandrogenism condition in PCOS patient (OR 0.02, 95% CI 0.00–0.04, p = 0.013). However, there was no significant difference observed between FGS and hyperandrogenism (p = 0.43). Conclusions: Triglycerides, testosterone, and SHBG were associated with hyperandrogenism in PCOS patients, while FGS showed no such association.

show abstract

Correlation of clinical and biochemical hyperandrogenism in Thai women with polycystic ovary syndrome

Cited by 16 publications

References 33 publications

Clinical, ultrasonographical and hormonal correlation in women with polycystic ovarian syndrome

Clinical, ultrasonographical and hormonal correlation in women with polycystic ovarian syndrome

Salivary testosterone measurement in women with and without polycystic ovary syndrome

Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS

Contact Info

Product

Resources

About