Correlation of coronary artery calcium score and carotid artery intima-media thickness with severity of coronary artery disease

Pathakota, Sudhakar Reddy; Rajasekhar, D.; Vanajakshamma, V.; Lakshmi, AY; Kasala, Latheef

doi:10.34172/jcvtr.2020.14

Cited by 10 publications

(9 citation statements)

References 14 publications

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“…CAC score and carotid artery intima-media thickness, can be measured as Gensini score to assess the severity of CAD [36]. It was demonstrated that short duration of sleep was associated with higher carotid artery Table 6 Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of sleep factors for Gensini score LAN, light at night; ORs, odds ratios; CIs, confidence intervals a They could read comfortably; b They could barely read; c They could see only the hazy outline of the bedroom; d Participants wore a mask to keep out light or they could not see their hand in front of their face; e Adjusted for age, sex, BMI, residence, education level, history of diabetes, hypertension and dyslipidemia, history of coronary artery disease, use of statins, antiplatelet agents, β-blockers, ACEI or ARB, smoking, drinking, diet and regular exercise; f Adjusted for age, sex, BMI, residence, education level, history of diabetes, hypertension and dyslipidemia, history of coronary artery disease, use of statins, antiplatelet agents, β-blockers, ACEI or ARB, smoking, drinking, diet and regular exercise, and adjusted mutually for other sleep factors without significant relationships with each other…”

Section: Discussionmentioning

confidence: 99%

Effects of sleep habits on acute myocardial infarction risk and severity of coronary artery disease in Chinese population

Lian

Wang

et al. 2021

BMC Cardiovasc Disord

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Background Growing evidence indicates that poor sleep harms health. Early to bed and early to rise is considered as a healthy lifestyle in Chinese population. The current study aimed to examine the effects of sleep habits on acute myocardial infarction (AMI) risk and severity of coronary artery disease (CAD) in Chinese population from two centers. Methods A total of 873 patients including 314 AMI cases and 559 controls were recruited from the inpatient cardiology department of the Affiliated Jiangning Hospital and the First Affiliated Hospital of Nanjing Medical University. 559 controls included 395 CAD cases and 164 non-CAD cases. We used a 17-item sleep factors questionnaire (SFQ) to evaluate sleep habits comprehensively by face-to-face interview. The severity of CAD was assessed by Gensini score in AMI and CAD groups. The effects of sleep factors on AMI risk and Gensini score were examined by unconditional logistic regression. Results After mutually adjustment for other sleep factors and demographic characteristics, the timing of sleep (24:00 and after) and morning waking (after 7:00) and sleep duration (< 6 h) were associated with increased risk of AMI (OR = 4.005, P < 0.001, OR = 2.544, P = 0.011 and OR = 2.968, P < 0.001, respectively). Lower level of light exposure at night was correlated with reduced risk of AMI (OR = 0.243, P = 0.009). In subgroup analysis by age, both late sleep timing and short sleep duration were associated with increased risk of AMI regardless of age. In subjects with age ≤ 65 years, daytime napping was related to reduced risk of AMI (OR = 0.645, P = 0.046). In subjects with age > 65 years, the frequency of night-time waking (3 times) was associated with increased risk of AMI (OR = 3.467, P = 0.035). Short sleep duration was correlated with increased risk of high Gensini score (OR = 2.374, P < 0.001). Conclusion Sleep insufficiency is an important risk factor both for AMI risk and CAD severity. Late sleeping is also associated with increased risk of AMI. In young and middle-aged people, regular naps may have a protective effect. Graphic abstract

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Section: Discussionmentioning

confidence: 99%

Effects of sleep habits on acute myocardial infarction risk and severity of coronary artery disease in Chinese population

Lian

Wang

et al. 2021

BMC Cardiovasc Disord

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“…Coronary artery calci cation (CAC), quantitated by CAC score, is a hallmark in the formation and accumulation of atherosclerotic plaque [31]. CAC score and carotid artery intima-media thickness, can be measured as Gensini score to assess the severity of CAD [32]. It was demonstrated that short duration of sleep was associated with higher carotid artery intima-media thickness [33] and incidence of CAC [34].…”

Section: Discussionmentioning

confidence: 99%

Effects of sleep habits on acute myocardial infarction risk and severity of coronary artery disease in Chinese population

Lian

Wang

et al. 2021

Preprint

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Background Growing evidence indicates that poor sleep harms health. Early to bed and early to rise is considered as a healthy lifestyle in Chinese population. The current study aimed to examine the effects of sleep habits on acute myocardial infarction (AMI) risk and severity of coronary artery disease (CAD) in Chinese population from two centers. Methods A total of 873 patients including 314 AMI and 559 controls were recruited from the inpatient cardiology department of the Affiliated Jiangning Hospital and the First Affiliated Hospital of Nanjing Medical University. 559 controls included 395 CAD cases and 164 non-CAD cases. We used a 17-item sleep factors questionnaire (SFQ) to evaluate sleep habits comprehensively by face-to-face interview. The severity of CAD was assessed by Gensini score in AMI and CAD groups. The effects of sleep factors on AMI risk and Gensini score were examined by unconditional logistic regression. Results After mutually adjustment for other sleep factors and demographic characteristics, the timing of sleep (24:00 and after), sleep duration (< 6h) and frequency of night-time waking (3 times) were associated with increased risk of AMI. In subjects with age < 65 years, sleep duration (< 6h) was correlated with increased risk of AMI (OR 3.096, 95%CI 1.435–6.681, P = 0.004) and daytime napping was related to reduced risk of AMI (OR 0.620, 95%CI 0.397–0.970,P = 0.036). In the population aged ≥ 65 years, the level 3 of light exposure (they could see only the hazy outline of the bedroom) was correlated with lowered risk of AMI. Late sleep timing (24:00 and after) and the frequency of night-time waking (3 times) were associated with increased risk of AMI independently of age. Moreover, Short sleep duration was correlated with increased risk of high Gensini score. Conclusion Late sleeping is an important risk factor for AMI. Daytime napping may protect the population aged < 65 years.

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“…The CACS provides a direct, noninvasive estimation of the atherosclerotic plaque burden in the coronary arteries by using either electron beam CT or multi-slice CT [28]. The CACS is one of the established surrogate markers of atherosclerosis and has an appropriate prognostic value that reflects the presence and the severity of CAD [29,30].…”

Section: Plos Onementioning

confidence: 99%

Association between gastroesophageal reflux disease and coronary atherosclerosis

et al. 2022

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Background and aim Gastroesophageal reflux disease (GERD) typically presents with symptoms of heartburn and acid regurgitation but occasionally manifests as atypical chest pain. Coronary artery disease (CAD) and GERD share some risk factors, such as smoking and obesity. The aims of this study were to evaluate the association between GERD and coronary atherosclerosis and to assess the risk factors for coronary atherosclerosis in GERD patients. Methods A total of 16616 subjects who underwent upper gastrointestinal endoscopy from 2003 to 2017 and a cardiac computed tomography (CT) scan within one year were included in this study. Coronary atherosclerosis was evaluated by the coronary artery calcium score (CACS). The severity of GERD was evaluated based on endoscopic findings using the Los Angeles classification. Results The proportion of high CACSs (≥100) increased significantly in subjects with severe GERD (p = 0.008). However, the presence of a high CACS did not increase the risk of GERD (OR = 1.007, 95% CI 0.857–1.182), nor did that of GERD increase the risk of a high CACS (OR = 1.018, 95% CI 0.865–1.198). The risk factors for a high CACS in GERD patients included age (OR = 1.087, 95% CI 1.066–1.109), male sex (OR = 5.645, 95% CI 2.561–12.446), hypertension (OR = 1.800, 95% CI 1.325–2.446), and hypercholesterolemia (OR = 1.684, 95% CI 1.213–2.338). Conclusions Although the presence of a high CACS did not increase the risk of GERD or vice versa, the proportion of high CACSs was significantly higher in subjects with severe GERD. Therefore, it might be helpful to assess the CACS in GERD patients with multiple risk factors.

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Correlation of coronary artery calcium score and carotid artery intima-media thickness with severity of coronary artery disease

Cited by 10 publications

References 14 publications

Effects of sleep habits on acute myocardial infarction risk and severity of coronary artery disease in Chinese population

Effects of sleep habits on acute myocardial infarction risk and severity of coronary artery disease in Chinese population

Effects of sleep habits on acute myocardial infarction risk and severity of coronary artery disease in Chinese population

Association between gastroesophageal reflux disease and coronary atherosclerosis

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