Correlation of E-cadherin, VEGF, COX-2 expression to prognostic parameters in papillary thyroid carcinoma

Erdem, Havva; Gündoğdu, Cemal; Şipal, Sare

doi:10.1016/j.yexmp.2011.01.008

Cited by 47 publications

(46 citation statements)

References 18 publications

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“…37 In agreement with a previous report, 38 the data described herein show that positive VEGF expression correlates with high MVD. In our series, an increased frequency of positive VEGF expression was associated with tumor enlargement among patients aged 50 years or older, of VEGF mRNA and protein has been well documented in PTC.…”

Section: 34supporting

confidence: 93%

Angiogenic and lymphangiogenic profiles in histological variants of papillary thyroid carcinoma

Skuletic¹,

Radosavljević²,

Pantic³

et al. 2017

Polish Archives of Internal Medicine

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Section: 34supporting

confidence: 93%

Angiogenic and lymphangiogenic profiles in histological variants of papillary thyroid carcinoma

Skuletic¹,

Radosavljević²,

Pantic³

et al. 2017

Polish Archives of Internal Medicine

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“…Previous study reported that young age may be associated with multiple gene alterations (8), and several investigations evaluated age distribution according to expression of p53, BRAF, Galectin-3, bcl-2, Cyclin D1 and cyclooxygenase-2 (Cox-2) levels. Most of these studies evaluated only one or just a few markers (9)(10)(11)(12)(13)(14). Further study is needed to elucidate the correlation between age and expressions of various molecular markers.…”

Section: Introductionmentioning

confidence: 99%

“…Analyzing molecular markers between elderly and young populations may provide clues to understand the molecular changes of the aging process. Several investigations reported that age distribution was not significantly different according to expressions of p53, BRAF, Galectin-3, bcl-2 and Cyclin D1 (9 -13), and was only marginally significantly different in expression of Cox-2 (14). However, lack of comparative data between elderly and young populations, and the heterogeneity of study designs and populations in previous studies hampers interpretations.…”

mentioning

confidence: 99%

Clinicopathologic Characteristics and Surgical Outcomes of Elderly Patients with Thyroid Cancer

Park

Jung

Lee

et al. 2014

Japanese Journal of Clinical Oncology

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Objective: Age is one of the important prognostic factors in thyroid cancer, and old age is generally related to higher rate of post-operative morbidity and mortality. The study analyzed the characteristics of thyroid cancer in elderly patients compared with those in younger patients. Methods: Patients who underwent surgery between 1992 and 2011 were enrolled. The patients were divided into those 70 years of age (older group) and ,70 years of age (younger group). Data including clinicopathological features and post-operative complications was analyzed. Molecular markers including Galectin-3, Cyclooxygenase-2, bcl-2, Cyclin D1, Epidermal growth factor receptor and BRAF mutation were reviewed. Survival analyses including recurrence-free survival and overall survival were examined. Results: Of 1867 patients, 98 were age-classified in older group and the remaining 1769 were in younger group. Older group displayed larger tumor size, and increased extrathyroidal extension, vascular invasion and neural invasion than younger group, and all were statistically significant. Molecular marker analyses revealed no significant differences between the groups. Post-operative complication rates were not significantly different between the older and younger groups in both univariate and multivariate analyses. Elderly patients showed poor recurrencefree survival and overall survival than younger patients in univariate analyses. However, age 70 years was not associated with poor recurrence-free survival after adjustment of confounding factors. Conclusion: Molecular features of elderly patients may be similar with younger patients. Even though aggravated clinicopathological features of thyroid carcinoma are more prevalent in elderly patients, thyroid surgery in elderly patients can be performed with favorable surgical and oncological outcomes.

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“…Soares et al (1997), as well as Nikiel et al (2006), reported that PTC which had lymph node involvement did not disclose any major difference in intensity of immunoreactivity and percentage of immunoreactive cells [14,16]. Erdem et al (2011) did not find any difference in E-CAD expression in relation to the size of tumor, capsule invasion or metastases [15]. On the other hand, Naito et al (2001) found that E-CAD expression was preserved significantly less often in papillary cancer with lymph node metastasis than in node-negative cases, but E-CAD expression did not correlate significantly with other clinical factors including tumor diameter, extracapsular tumor extension or histological differentiation [12].…”

Section: Discussionmentioning

confidence: 99%

“…Evaluation of E-CAD in the thyroid has focused on the relation of E-CAD expression to size of tumor, lymph nodules involvement or presence of metastasis, but the reported results are not consistent [8][9][10][11][12][13][14][15]. In only some of those reports has the expression of E-CAD been evaluated in relation to histologic subtype of papillary thyroid cancer or the pattern of local invasion in follicular cancers (minimally invasive versus widely invasive) [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumors

Słowińska-Klencka

Sporny²,

Stasikowska-Kanicka³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:The aim of this study was to evaluate the relationship between abnormal expression of E-cadherin (E-CAD) and the extracapsular extension of tumors, lymph node involvement and the presence of metastasis in various types of thyroid cancers. Histopathological specimens of 35 benign thyroid lesions and 122 malignant tumors (papillary, follicular, poorly differentiated and undifferentiated cancers) were analyzed. E-CAD immunostaining intensity, its subcellular localization, homogeneity within lesion, and the relation of staining intensity between tumor and surrounding thyroid parenchyma were evaluated. The obtained results show that the variants of differentiated cancers with a poorer prognosis (i.e. tall cell and follicular variants of papillary cancer and widely invasive follicular cancers) present reduced intensity of E-CAD expression, its abnormal localization or heterogeneity of staining more frequently than classical papillary cancers and minimally invasive follicular cancers. However, the assessment of E-CAD expression does not allow the prediction of extrathyroidal growth of thyroid cancers.

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Correlation of E-cadherin, VEGF, COX-2 expression to prognostic parameters in papillary thyroid carcinoma

Cited by 47 publications

References 18 publications

Angiogenic and lymphangiogenic profiles in histological variants of papillary thyroid carcinoma

Angiogenic and lymphangiogenic profiles in histological variants of papillary thyroid carcinoma

Clinicopathologic Characteristics and Surgical Outcomes of Elderly Patients with Thyroid Cancer

E-cadherin expression is more associated with histopathological type of thyroid cancer than with the metastatic potential of tumors

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