Correlation of GLUT-1 Overexpression, Tumor Size, and Depth of Invasion with 18F-2-fluoro-2-deoxy-d-glucose Uptake by Positron Emission Tomography in Colorectal Cancer

Gu, Jie; Yamamoto, Hirofumi; Fukunaga, Hisanori; Danno, Katsuki; Takemasa, Ichiro; Ikeda, Masataka; Tatsumi, Mitsuaki; Sekimoto, Mitsugu; Hatazawa, Jun; Nishimura, Tsunehiko; Monden, Morito

doi:10.1007/s10620-006-9428-2

Cited by 75 publications

(41 citation statements)

References 27 publications

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“…This process is considered to be mediated by glucose transporters (GLUTs). Among GLUTs, GLUT-1 is one of the most significant mediators of increased glucose influx into cells (3). The rate of glucose transport via GLUT-1 may be altered under conditions in which the metabolic rate must be adjusted, including during cell division (mitosis and meiosis), differentiation, transformation and nutrient starvation (4).…”

Section: Introductionmentioning

confidence: 99%

Expression and significance of hypoxia-inducible factor-1α and glucose transporter-1 in laryngeal carcinoma

Chen

Jianying

et al. 2012

Oncology Letters

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Abstract. Malignant cells show increased glucose uptake in vitro and in vivo. This process is considered to be mediated by glucose transporters (GLUTs). Hypoxia-inducible factor-1α (HIF-1α) may upregulate GLUT-1 expression. Little is known about the correlation between HIF-1α and GLUT-1 expression in laryngeal carcinoma. The current study investigated this correlation immunohistochemically, according to various clinical and pathological features, in 49 paraffin-embedded archival tissue blocks from patients with laryngeal squamous cell carcinoma. HIF-1α and GLUT-1 expression was detected in 63.3 (31/49) and 55.1% (27/49) of the tumour samples, respectively. HIF-1α expression was significantly correlated with lymph node classification (P= 0.018), recurrence (P= 0.02) and metastasis (P= 0.031). GLUT-1A expression was significantly associated with recurrence (P=0.02) and metastasis (P=0.01). Univariate analyses revealed that HIF-1α (χ 2 =8.2; P=0.004) and GLUT-1 expression (χ 2 =9.0; P=0.003) were significantly associated with a poorer survival rate. In a multivariate analysis, GLUT-1 expression (P=0.006) was a significant predictor of poor survival rate, as well as the primary tumour site, lymph node invasion and distant metastasis. Based on Spearman's analysis, GLUT-1 expression and phosphatidylinositol 3-kinase (PI3K) expression were significantly correlated (r=0.504; P=0.000). This is the first study to demonstrate a significant correlation between GLUT-1 and HIF-1α expression in laryngeal carcinoma and to show increased GLUT-1 expression as an independent survival rate predictor. These results suggest that GLUT-1 is a potential new therapeutic target for laryngeal carcinoma.

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Section: Introductionmentioning

confidence: 99%

Expression and significance of hypoxia-inducible factor-1α and glucose transporter-1 in laryngeal carcinoma

Chen

Jianying

et al. 2012

Oncology Letters

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“…Studies are currently conducted as well with regard to the correlation between 18 F-FDG uptake and expression of GLUT-1 in relation to the increase of glucose metabolism of cancer cell, 1 seemed to be weakened by these effects. Note, however, that there was correlation between the expression of GLUT-1 and 18 F-FDG uptake in non-small cancer cells in the lung, colon cancer, and sarcoma 9,18,28 . A few previous studies also reported clinical correlation between glucose metabolism and PET image 13,15,29 .…”

Section: Correlation Between Gss and Histological Diffe Renti Ation mentioning

confidence: 88%

Correlation between glucose transporter type-1 expression and¹⁸F-FDG uptake on PET in oral cancer

Kim

2012

J Korean Assoc Oral Maxillofac Surg

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(J Korean Assoc Oral Maxillofac Surg 2012;38:212-20) Objectives: Fluorine-18 fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) is a non-invasive diagnostic tool for many human cancers wherein glucose uptake transporter-1 (GLUT-1) acts as a main transporter in the uptake of 18 F-FDG in cancer cells. Increased expression of glucose transporter-1 has been reported in many human cancers. In this study, we investigated the correlation between 18 F-FDG accumulation and expression of GLUT-1 in oral cancer. Materials and Methods: We evaluated 42 patients diagnosed with oral squamous cell carcinoma (OSCC) and malignant salivary gland tumor as confirmed by histology. 42 patients underwent pre-operative 18 F-FDG PET, with the maximum standardized uptake value (SUV max ) measured in each case. Immunohistochemical staining was done for each histological specimen, and results were evaluated post-operatively according to the percentage (%) of positive area, intensity, and staining score. Results: For OSCC, SUV max significantly increased as T stage of tumor classification increased. For malignant salivary gland tumor, SUV max significantly increased as T stage of tumor classification increased. For OSCC, GLUT-1 was expressed in all 36 cases. GLUT-1 staining score (GSS) increased as T stage of tumor classification increased, with the difference statistically significant. For malignant salivary gland tumor, GLUT-1 expression was observed in all 6 cases; average GSS was significantly higher in patients with cervical lymph node metastasis than that in patients without cervical lymph node metastasis. Average GSS was higher in OSCC (11.11±1.75) than in malignant salivary gland tumor (5.33±3.50). No statistically significant correlation between GSS and SUV max was observed in OSCC or in malignant salivary gland tumor. Conclusion: We found no statistically significant correlation between GSS and SUV max in OSCC or in malignant salivary gland tumor. Studies on the various uses of GLUT during 18 F-FDG uptake and SUV and GLUT as tumor prognosis factor need to be conducted through further investigation with large samples.Key words: Mouth neoplasms, Positron-emission tomography, Glucose transporter-1, Standardized uptake value [paper submitted 2012. 4. 23 / revised 2012. 5. 22 / accepted 2012. 5. 25] 5-year survival rate of 50% 2 . Most oral cancers can be detected at the early stage through simple ocular inspection or palpation, but it is important to determine the stage of the cancer precisely since the complete elimination of the primary tumor and cervical lymphatic metastasis are essential for successful treatment considering the long-term survival rate and the prognosis of the patient. 18F-Fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) is a noninvasive method capable of diagnosing the primary tumor in the early stage as well as lymphatic metastasis and remote metastasis and evaluating the prognosis of the patient. Furthermore, it allows tracking observation for the treatment process and re...

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“…That cellular glucose metabolism may be correlated with tumor growth and aggressiveness has been suggested in some studies [17][18][19][20][21] . Previous in vitro and clinical studies indicated an association between elevated FDG uptake and colon tumor glucose metabolism, such as the activity of GLUT1, Ki-67, and p53 [13,[22][23][24][25] . A study by Gu et al [22] indicated that tumor size and depth of invasion were associated with higher SUVs in both primary colon tumors and hepatic metastatic foci.…”

Section: Discussionmentioning

confidence: 99%

“…Previous in vitro and clinical studies indicated an association between elevated FDG uptake and colon tumor glucose metabolism, such as the activity of GLUT1, Ki-67, and p53 [13,[22][23][24][25] . A study by Gu et al [22] indicated that tumor size and depth of invasion were associated with higher SUVs in both primary colon tumors and hepatic metastatic foci. However, the study was limited by a small sample size (20 patients) and survival analysis was not performed.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of 18-fluorodeoxyglucose positron emission tomography-computed tomography in resectable colorectal cancer

Lee

Kim²,

Kim³

et al. 2012

WJG

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AIM:To assess the prognostic value of preoperative 18 fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) in patients with resectable colorectal cancer. METHODS:One hundred sixty-three patients with resectable colorectal cancer who underwent FDG-PET/CT before surgery were included. Patient data including pathologic stage at presentation, histology, treatment, disease-free survival and the maximum standardized uptake value (SUVmax) of the primary tumor on FDG-PET/CT were retrospectively analyzed. Median follow up duration was 756 (range, 419-1355). The primary end point was disease-free survival.RESULTS: Twenty-five of 163 patients (15.3%) had recurrences. The median SUVmax values of the recurrence and no-recurrence groups were 8.9 (range, 5-24) and 8.2 (range, 0-23, P = 0.998). Receiver operating characteristic (ROC) curve analysis showed no significant association between SUVmax and recurrence (area under the curve = 0.5, P = 0.998, 95% CI: 0.389-0.611). Because a statistically significant value was not found, SUVmax was dichotomized at its median of 8.6. The disease-free survival curve was analyzed using the median SUVmax (8.6) as the cut off. Univariate and multivariate analysis did not provide evidence that disease-free survival rates for the subgroups defined by the median SUVmax were significantly different (P = 0.52, P = 0.25). CONCLUSION:Our study suggests that the high FDG uptake of primary mass in resectable colorectal cancer doesn't have a significant relationship with tumor recurrence and disease-free survival.

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Correlation of GLUT-1 Overexpression, Tumor Size, and Depth of Invasion with 18F-2-fluoro-2-deoxy-d-glucose Uptake by Positron Emission Tomography in Colorectal Cancer

Cited by 75 publications

References 27 publications

Expression and significance of hypoxia-inducible factor-1α and glucose transporter-1 in laryngeal carcinoma

Expression and significance of hypoxia-inducible factor-1α and glucose transporter-1 in laryngeal carcinoma

Correlation between glucose transporter type-1 expression and¹⁸F-FDG uptake on PET in oral cancer

Prognostic value of 18-fluorodeoxyglucose positron emission tomography-computed tomography in resectable colorectal cancer

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Correlation of GLUT-1 Overexpression, Tumor Size, and Depth of Invasion with 18F-2-fluoro-2-deoxy-d-glucose Uptake by Positron Emission Tomography in Colorectal Cancer

Cited by 75 publications

References 27 publications

Expression and significance of hypoxia-inducible factor-1α and glucose transporter-1 in laryngeal carcinoma

Expression and significance of hypoxia-inducible factor-1α and glucose transporter-1 in laryngeal carcinoma

Correlation between glucose transporter type-1 expression and18F-FDG uptake on PET in oral cancer

Prognostic value of 18-fluorodeoxyglucose positron emission tomography-computed tomography in resectable colorectal cancer

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Correlation between glucose transporter type-1 expression and¹⁸F-FDG uptake on PET in oral cancer