Correlation of human papillomavirus infection and clinical parameters with five-year survival in oral squamous cell carcinoma

Ali, Saleema Mehboob; Awan, M. S.; Atif, S; Nasir, Aejaz; Mirza, Yumna

doi:10.1017/s0022215118000361

Cited by 9 publications

(7 citation statements)

References 29 publications

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“…Despite recent advances in imaging technology and treatment modalities, the last few decades have seen limited improvement in the survival rate of oral cancer. At our centre, we have observed approximately 40–50% of patients survive five years following diagnosis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

High CD44 Immunoexpression Correlates with Poor Overall Survival: Assessing the Role of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma Patients from the High-Risk Population of Pakistan

Adnan

Ali

Farooqui

et al. 2022

International Journal of Surgical Oncology

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Oral squamous cell carcinoma (OSCC) is a top-ranked cancer in the Pakistani population, and patient survival has remained unchanged at ∼50% for several decades. Recent advances have claimed that a subset of tumour cells, called cancer stem cells (CSCs), are responsible for tumour progression, treatment resistance, and metastasis, which leads to a poor prognosis. This study investigated the impact of CSC markers expression on overall survival (OS) and disease-free survival (DFS) of OSCC patients. Materials and Methods. Immunohistochemistry was used to evaluate CD44, CD133, L1CAM, and SOX2 expression in a well-characterized cohort of 100 Pakistani patients with primary treatment naïve OSCC. The immunoreactivity for each marker was correlated with patient clinicopathologic characteristics, oral cancer risk chewing habits, and survival. The minimum follow-up time for all patients was five years, and survival estimates were calculated using the Kaplan–Meier method and Cox proportional hazards model. Results. In this cohort of 100 patients, there were 57 males and 43 females. The median OS and DFS time durations observed were 64 and 52.5 months, respectively. Positive expression for CD44, CD133, L1CAM, and SOX2 was observed in 33%, 23%, 41%, and 63% of patients. High CD44 expression correlated with decreased OS ( P = 0.047 ) but did not influence DFS. However, CD133, L1CAM, and SOX2 had no effect on either OS or DFS. Tonsils, nodal involvement, and AJCC stage were independent predictors of worse OS and DFS both. Conclusion. Of the CSC markers investigated here, only CD44 was a predictor for poor OS. CD44 was also associated with advanced AJCC and T stages. Interestingly, CD133 was significantly lower in patients who habitually consumed oral cancer risk factors.

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Section: Introductionmentioning

confidence: 99%

High CD44 Immunoexpression Correlates with Poor Overall Survival: Assessing the Role of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma Patients from the High-Risk Population of Pakistan

Adnan

Ali

Farooqui

et al. 2022

International Journal of Surgical Oncology

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“…The most correlated envvironmental factor is tobacco smoking and exposure of the mucosa to alcohol (3). The human papillomavirus (HPV), is especially associated with oropharyngeal carcinoma and its association with oral cavity cancer in not conclusive (4).…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth

Domingueti

Janini²,

Paranaíba

et al. 2019

Med Oral

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Background Diverse studies have evidenced that chemokines can play a critical role in pathogenesis of oral squamous cell carcinoma (SCC). The main chemokines involved in oral carcinogenesis, tumor invasion and metastasis are CCR4, CCR5, CCR7 and CXCR4, and our aim was to evaluate the prognostic value of the immunoexpression of these chemokines in SCC of tongue and floor of the mouth. Material and Methods A retrospective descriptive study of the immunohistochemical expression of CCR4, CCR5, CCR7 and CXCR4 in paraffin-embedded samples of 124 patients with SCC of the tongue and floor of the mouth was performed, considering 98 cases from Brazil and 26 cases from Chile. Associations between variables were analyzed using chi-square test. Survival curves were performed using the Kaplan-Meier method and compared with long-rank test. For multivariate survival analysis, the Cox hazard model was established. The level of significance established was p ≤0.05. Results The statistical analysis showed that samples with well or moderate WHO model differentiation ( p =0.001) and a high expression of CCR5 ( p =0.05) were significantly associated with a higher disease specific survival, which were also observed in Cox´s multivariate analysis ( p =0.01). A higher expression of CCR7 ( p =0.01) interfered significantly in disease-free survival in univariate analysis and in Cox´s multivariate analysis ( p =0.05). Conclusions These results support additional evidence, showing that chemokine receptors CCR5 and CCR7 are helpful as biomarkers of poor prognosis in patients with SCC of the tongue and floor of the mouth. Key words: Oral squamous cell carcinoma, prognosis, survival, chemokine receptor.

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“…The HPV genotypes detected in head and neck squamous cell carcinoma (HNSCC) might differ from those in cervical cancers. HPV16 remains the most prevalent detected type (1.6–60.7%), followed by HPV31 (1.6–79.2%), HPV18 (0.7–15.1%), HPV56 (0.5–15.1%), HPV52 (2%), HPV33 (1.2%), and HPV35 (0.5%) [ 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 ]. Intriguingly, HPV31 (79.2%), HPV45 (87.4%), and HPV68 (49.1%) have been reported to have particularly high rates in Singapore.…”

Section: Hpv Genotype Distribution In East Southeast and South Asiamentioning

confidence: 99%

“…For HNSCC samples with a single HPV infection, most of the samples have been found to be positive for HPV16. Other detected hrHPV types include HPV31, 18, 56, 52, 33, and 35 [ 84 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 ]. Additionally, samples detected with HPV16/18 co-infection and multiple HPV genotypes were also reported [ 110 ].…”

Section: Hpv Genotype Distribution In East Southeast and South Asiamentioning

confidence: 99%

Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia

Xia

Long

et al. 2021

Cancers

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Human papillomavirus (HPV) infection remains one of the most prominent cancer-causing DNA viruses, contributing to approximately 5% of human cancers. While association between HPV and cervical cancers has been well-established, evidence on the attribution of head and neck cancers (HNC) to HPV have been increasing in recent years. Among the cancer-causing HPV genotypes, HPV16 and 18 remain the major contributors to cancers across the globe. Nonetheless, the distribution of HPV genotypes in ethnically, geographically, and socio-economically diverse East, Southeast, and South Asia may differ from other parts of the world. In this review, we garner and provide updated insight into various aspects of HPV reported in recent years (2015–2021) in these regions. We included: (i) the HPV genotypes detected in normal cancers of the uterine cervix and head and neck, as well as the distribution of the HPV genotypes by geography and age groups; (ii) the laboratory diagnostic methods and treatment regimens used within these regions; and (iii) the oncogenic properties of HPV prototypes and their variants contributing to carcinogenesis. More importantly, we also unveil the similarities and discrepancies between these aspects, the areas lacking study, and the challenges faced in HPV studies.

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Correlation of human papillomavirus infection and clinical parameters with five-year survival in oral squamous cell carcinoma

Abstract: There is a high prevalence of HPV positive oral squamous cell carcinoma in Pakistan; however, there is no difference in the five-year survival rate when compared to HPV negative oral squamous cell carcinoma.

Cited by 9 publications

References 29 publications

High CD44 Immunoexpression Correlates with Poor Overall Survival: Assessing the Role of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma Patients from the High-Risk Population of Pakistan

High CD44 Immunoexpression Correlates with Poor Overall Survival: Assessing the Role of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma Patients from the High-Risk Population of Pakistan

Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth

Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia

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