Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population

Wang, Changyuan; Li, Wei; Chu, W.K.; Yu, Haiyang; Yu, Xinjuan; Li, Chunxia

doi:10.1016/j.bjid.2019.09.001

Cited by 1 publication

(4 citation statements)

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“…The IL-18 plays a significant role in the regulation of immune responses and inflammation and it also plays a role in the pathophysiology and genesis of viral and inflammatory diseases 30 . Due to its immune-stimulating and anti-cancer actions, IL-18 has been proposed as a viable adjuvant therapy for cancer [15][16][17] . However, IL-18 has been linked to the advancement of the disease and in some malignancies, with the likelihood of recurrence and is raised in the blood of the majority of cancer patients [17][18][19] .…”

Section: Discussionmentioning

confidence: 99%

“…Due to its immune-stimulating and anti-cancer actions, IL-18 has been proposed as a viable adjuvant therapy for cancer [15][16][17] . However, IL-18 has been linked to the advancement of the disease and in some malignancies, with the likelihood of recurrence and is raised in the blood of the majority of cancer patients [17][18][19] . It is also addressed how Rhodomyrtone, a bioactive substance found in Rhodomyrtus tomentosa leaves, prevents A431 epidermoid carcinoma cells from spreading malignancy 25,26 .…”

Section: Discussionmentioning

confidence: 99%

“…Serum IL-18 may serve as a helpful biological prognostic indicator on its own 16 . The IL-18 gene polymorphism is a significant genetic risk factor for cervical neoplasms 17 . The IL-18 is a proinflammatory and immune-regulatory cytokine 15 .…”

Section: Introductionmentioning

confidence: 99%

“…The IL-18 is a proinflammatory and immune-regulatory cytokine 15 . Casp1 enzymatically processes the inactive precursor (pro-IL-18) into the mature form of IL-18 17 . Through the stimulation of NK and/or T cell responses, IL-18 has been studied in clinical trials on cancer patients and has demonstrated anti-tumour effectiveness in numerous preclinical models of cancer immunotherapy 18,19 .…”

Section: Introductionmentioning

confidence: 99%

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PDGF-β and IL-18 Expressions on Carcinoma Cervical by Rhodomyrtus tomentosa

Simanullang¹,

Situmorang²,

Ginting³

et al. 2022

Pakistan J. of Biological Sciences

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Background and Objective: Cervical cancer, along with lung and breast cancer, is one of Indonesiaʼs most aggressive gynaecological diseases. Rhodomyrtus tomentosa has antioxidant and antiproliferative properties that could be developed into herbal medicines for molecular therapy. The IL-18 and PDGF-$ are tumour-promoting agent proteins that may be therapeutic targets for a variety of cancers that were investigated in this study. Materials and Methods: Rats were classified into five groups: Group C-is the control group, Group C+ is the cancer model group and Group RHO200 is the Rhodomyrtus tomentosa 100 mgG 1 b.wt., rat group, Group RHO400 is the Rhodomyrtus tomentosa 200 mgG 1 b.wt., rat group and Group RHO400 is the Rhodomyrtus tomentosa 400 mgG 1 b.wt., rat group. The rats were dissected 30 days after receiving Rhodomyrtus tomentosa. Immunohistochemistry is used to stain cervical tissues. Results: The expression of IL-18 and PDGF-$ was significantly different (p<0.01). The IL-18 and PDGF-$ were most abundant at the lowest Rhodomyrtus tomentosa doses (100-200 mg kgG 1 b.wt.), while they were least abundant at the 400 mg kgG 1 b.wt., doses. Histological analysis revealed that the highest dose of IL-18 and PDGF-$ expression reduced abnormal tissue and the space between tumours, followed by several carcinoma cells that stopped growing. Conclusion: Rhodomyrtus tomentosa can be used as a herbal therapy to reduce the expression of PDGF-$ and IL-18 (two cancer marker agents).

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