Correlation of OX40 ligand on B cells with serum total IgE and IL-4 levels by CD4+ T cells in allergic rhinitis

Fouladi, Saloomeh; Masjedi, Mohsen; Hakemi, Mazdak Ganjalikhani; Ghasemi, Ramin; Eskandari, Nahid

doi:10.1016/j.aller.2018.07.003

Cited by 3 publications

(1 citation statement)

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“…Because T cells are also activated through this interaction, the OX40/OX40L interaction appears to induce bidirectional signaling events (215, 216). A recent analysis of OX40L expression levels in B cells from patients with allergic rhinitis indicated that OX40L expression is positively correlated with allergic markers, such as serum levels of IgE and IL-4 (217).…”

Section: Reverse Signaling Initiated From Other Tnfsf Membersmentioning

confidence: 99%

Reverse Signaling of Tumor Necrosis Factor Superfamily Proteins in Macrophages and Microglia: Superfamily Portrait in the Neuroimmune Interface

et al. 2019

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The tumor necrosis factor (TNF) superfamily (TNFSF) is a protein superfamily of type II transmembrane proteins commonly containing the TNF homology domain. The superfamily contains more than 20 protein members, which can be released from the cell membrane by proteolytic cleavage. Members of the TNFSF function as cytokines and regulate diverse biological processes, including immune responses, proliferation, differentiation, apoptosis, and embryogenesis, by binding to TNFSF receptors. Many TNFSF proteins are also known to be responsible for the regulation of innate immunity and inflammation. Both receptor-mediated forward signaling and ligand-mediated reverse signaling play important roles in these processes. In this review, we discuss the functional expression and roles of various reverse signaling molecules and pathways of TNFSF members in macrophages and microglia in the central nervous system (CNS). A thorough understanding of the roles of TNFSF ligands and receptors in the activation of macrophages and microglia may improve the treatment of inflammatory diseases in the brain and periphery. In particular, TNFSF reverse signaling in microglia can be exploited to gain further insights into the functions of the neuroimmune interface in physiological and pathological processes in the CNS.

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Section: Reverse Signaling Initiated From Other Tnfsf Membersmentioning

confidence: 99%

Reverse Signaling of Tumor Necrosis Factor Superfamily Proteins in Macrophages and Microglia: Superfamily Portrait in the Neuroimmune Interface

et al. 2019

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Research progress in OX40/OX40L in allergic diseases

Song,

Zhang,

Liang

2024

Int Forum Allergy Rhinol

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OX40/OX40L are costimulatory molecules in the tumor necrosis factor superfamily. Numerous studies have shown that OX40/OX40L are involved in immune regulation, especially in the proliferation and differentiation of T cells and the generation of memory T cells, which play important roles in allergic diseases. In recent years, the use of OX40/OX40L as therapeutic targets for treating T‐cell‐mediated diseases has attracted the interest of scholars. This paper reviews the role of OX40/OX40L in allergic diseases and the progress in clinical treatments targeting this signaling pathway.

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