Correlation of platelet‐to‐lymphocyte ratio and neutrophil‐to‐lymphocyte ratio with thrombolysis in myocardial infarction frame count in ST‐segment elevation myocardial infarction

Vakili, Hossein; Shirazi, Mahin; Charkhkar, Mahsa; Khaheshi, Isa; Memaryan, Mehdi; Naderian, Mohammadreza

doi:10.1111/eci.12736

Cited by 40 publications

(32 citation statements)

References 34 publications

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“…What we found in other studies was to illustrate the role of some platelet indices in predicting the severity of reperfusion defect. In a study by Vakili et al, and quite similar to our study, the platelet-to-lymphocyte ratio had a strong statistical correlation with TIMI frame count and corrected TIMI frame count [11]. In a study by Yaşar et al, there was a weak correlation between the two MPVs and the corrected TIMI frame count.…”

Section: Discussionsupporting

confidence: 89%

Correlation of platelet indices with TIMI frame count in patients undergoing primary PCI due to ST-segment elevation myocardial infarction

Salehi

Namazi

Safi

et al. 2019

ijcp

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Introduction: Given the fundamental role of platelet indices in the development of atherosclerotic plaque, these indices may play a predictive role for the occurrence of disturbed coronary reperfusion. The present study evaluated the association between platelet indices and coronary reperfusion status based on the Thrombolysis in Myocardial Infarction (TIMI) frame count. Methods: This cross-sectional study was conducted on 98 consecutive patients with ST elevation myocardial infarction who were candidate for primary Percutaneous Coronary Intervention (PCI) at Modarres Hospital in Tehran between January 2016 and January 2018. Venous samples were extracted from all patients before primary PCI. To assess the condition of coronary reperfusion after primary PCI, the TIMI frame count related to culprit artery in acute myocardial infarction was determined. Results: The TIMI frame count was positively associated with platelet count (r = 0.320, P = 0.001) and more strongly with platelet to lymphocyte ratio (r = 0.375, P < 0.001), but not with other platelet indices such as platelet distribution width (PDW), mean platelet volume (MPV) or Platelet large cell ratio (PLCR). According to the ROC curve analysis, platelet to lymphocyte ratio was introduced as a valuable parameter for differentiating complete from disturbed reperfusion (AUC = 0.735, 95%CI: 0.613-0.858, P = 0.001). The best cutoff value for platelet to lymphocyte ratio in predicting disturbed reperfusion was 146.5 with a sensitivity of 81.8% and a specificity of 60.5%. However, other platelet indices could not present this predictive role. Conclusion: The platelet to lymphocyte ratio with predictive accuracy and sensitivity predicts coronary perfusion impairment based on the increase in TIMI frame count.

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Section: Discussionsupporting

confidence: 89%

Correlation of platelet indices with TIMI frame count in patients undergoing primary PCI due to ST-segment elevation myocardial infarction

Salehi

Namazi

Safi

et al. 2019

ijcp

Self Cite

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“…The increasing number of leukocyte subtypes, such as eosinophils, neutrophils, and monocytes, is associated with adverse cardiovascular and cerebrovascular events and carotid stenosis (Gijsberts et al, 2017;Hyun et al, 2015;Nunez et al, 2009;Vakili et al, 2017). Monocyte/ lymphocyte ratio (MLR, monocyte count/lymphocyte count), neutrophil/lymphocyte ratio (NLR, neutrophil count/lymphocyte count), and platelet/lymphocyte ratio (PLR, platelet count/lymphocyte count) are indicators reflecting the degree of inflammation (Gijsberts et al, 2017;Hyun et al, 2015;Vakili et al, 2017). These parameters or indices are derived from calculations formulated from results obtained from a routine blood analysis; the predictive value of these results obtained from laboratory testing provides a relatively noninvasive and accessible means of obtaining information and profiling individual patients in a time-sensitive manner in the workup for patient with stroke.…”

Section: Introductionmentioning

confidence: 99%

Monocyte/lymphocyte ratio is associated with carotid stenosis in ischemic stroke: A retrospective analysis

et al. 2019

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Background Carotid artery stenosis, mainly caused by carotid atherosclerosis, is related to ischemic stroke. This study was to investigate whether monocyte/lymphocyte ratio (MLR) was associated with increased severity of carotid stenosis in patients with ischemic stroke. Methods A total of 395 participants with ischemic stroke were retrospectively analyzed. The severity of carotid stenosis was evaluated by ultrasound examination. Patients were divided into two groups: nonsevere stenosis group and severe stenosis group. Multivariate logistic analysis was used to evaluate risk factors. Results A significant correlation was found between MLR and the severity of carotid stenosis in patients with ischemic stroke. MLR was the independent risk factor of carotid stenosis (OR: 9.74, 95% CI: 1.16–81.54). In the ROC curves analysis, a cutoff value of 0.20 for MLR predicted the severity of carotid stenosis with a sensitivity of 80.40% and specificity of 26.40% (ROC area under the curve: 0.598, 95% CI: 0.53–0.67, p = .004). Conclusion Monocyte/lymphocyte ratio plays important roles in carotid stenosis in patients with ischemic stroke and is an independent risk factor of the severity of carotid stenosis. Therefore, MLR might be considered a potential index in the diagnosis of carotid stenosis in patients with ischemic stroke.

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“…In a previous study, it was suggested that the increase of platelet count in patients with thrombus may be due to multiple in ammatory mediators that stimulate megakaryocyte proliferation and thus produce more platelets [18]. In contrast, lymphocytes are known to control in ammatory pathways [19,20]. A decreased lymphocyte count may aggravate the injury of cerebral infarction and neurological de cits [21].…”

Section: Discussionmentioning

confidence: 99%

Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients

Sun¹,

Wang²,

Wang³

et al. 2020

Preprint

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Introduction: The role of Platelet-to-lymphocyte ratio (PLR) in outcomes of acute ischemic stroke, especially before and after intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA), has not been elucidated. Thus, the aim of this study was to evaluate the effect of PLR before and after rtPA on clinical outcomes.Methods: A total of 582 consecutive patients who had acute ischemic stroke diagnosed and received intravenous thrombolysis with rtPA were included in this study. We collected demographics, vascular risk factors, previous history of drugs and other clinical information for all patients. Specifically, blood samples for PLR values were collected on admission and at 24 hours after stroke. Multivariate logistic regression analysis was used to assess the association between PLR with the risk of poor outcome (mRS≥3), death and hemorrhagic transformation (HT). Results: Of 582 patients, 191 (32.8%) had a poor outcome, 40 (6.9%) died and 82 (14.1%) had HT. After adjustment for potential confounders, multivariate logistic regression analysis showed that higher PLR at 24h after rtPA was independently associated with an increased risk of poor outcome (OR=1.004; 95% CI:1.001-1.007; P=0.009) and the occurrence of death (OR=1.009; 95% CI:1.004-1.013; P<0.001), but not associated with the risk of HT (OR=1.003; 95% CI:0.999-1.007; P=0.165). In addition, PLR on admission was not associated with the risk of poor outcome, death and HT (all P>0.05).Conclusions: We found that PLR at 24h after rtPA can predict the risk of poor outcome and death in acute ischemic stroke patients, but PLR on admission cannot.

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Correlation of platelet‐to‐lymphocyte ratio and neutrophil‐to‐lymphocyte ratio with thrombolysis in myocardial infarction frame count in ST‐segment elevation myocardial infarction

Cited by 40 publications

References 34 publications

Correlation of platelet indices with TIMI frame count in patients undergoing primary PCI due to ST-segment elevation myocardial infarction

Correlation of platelet indices with TIMI frame count in patients undergoing primary PCI due to ST-segment elevation myocardial infarction

Monocyte/lymphocyte ratio is associated with carotid stenosis in ischemic stroke: A retrospective analysis

Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients

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