Correlation of resting heart rate with the severity and complexity of coronary artery disease: A single-center retrospective study

Abstract

Background: We aimed to explore the association between resting heart rate (RHR) and the severity and complexity of atherosclerosis in coronary artery disease (CAD). Methods: Clinical and laboratory data of 388 patients who underwent coronary angiography were evaluated retrospectively. SYNTAX and Gensini scores were calculated based on angiographic findings. These scores which indicate the severity of atherosclerosis was calculated for all the patients. Patients were divided into three main groups according to RHR. Group 1 composed of patients with RHR ≤70 ( n = 217), group 2 composed of patients with RHR between 70 and 89 ( n = 133), and group 3 composed of patients with RHR ≥90 beats per min (bpm) ( n = 38). Gensini and SYNTAX score values of the three study groups were compared. Also, Gensini score was tested for whether it showed a positive correlation with RHR and SYNTAX scores. Results: All patients had an average age of 61.3 years, and the mean for RHR was 72 bpm. Mean Gensini score in the general CAD population was 24.4 ± 22.5, and mean SYNTAX score was 13.6 ± 8.1 points. The Gensini and Syntax score values of the group 3 were significantly higher than that of the other two groups (59.8 ± 31.2, P < 0.001 and 26.0 ± 6.5, P < 0.001, respectively). There was a significant correlation with Gensini score and RHR, SYNTAX score, C-reactive protein (CRP), and left ventricular ejection fraction [( r = 0.725, P < 0.001), ( r = 0.680, P < 0.001), ( r = 0.543, P < 0.001), ( r = −0.224, P < 0.001), respectively]. Conclusions: RHR is an effective easily available marker for the assessment of severity and complexity of CAD.

Comparison of Buyang Huanwu granules and Naoxintong capsules in the treatment of stable angina pectoris: rationale and design of a randomized, blinded, multicentre clinical trial

“…The mortality rate due to cardiovascular diseases accounts for more than 40% of all-cause deaths in China [3]. Coronary artery disease (CAD), a common cardiovascular disease, is the leading cause of morbidity and mortality worldwide [4,5]. Angina pectoris is the most common symptom of CAD and a major cause of disability.…”

“…Participants are allowed to withdraw at any time without having to give a reason. The withdrawal criteria are as follows: (1) participants request withdrawal from the study; (2) there is exacerbation or deterioration that is clearly related to the treatment; (3) an allergic reaction that is clearly associated with the study drug occurs; (4) participants show comorbidities, complications, adverse events (AEs), or serious adverse events (SAEs) during the trial; (5) there is use of forbidden drugs or receipt of prohibited treatment; (6) participants show poor adherence, or the amount of drug used does not meet the regulations (< 80%); and (7) blinding is uncovered or emergency unblinding is required.…”

Relationship between Severity and Complexity of Coronary Artery Involvement and Obstructive Sleep Apnea Based on STOP-BANG Questionnaire

“…C-reactive protein (CRP), tissue factor, and heat shock protein-70 (atherosclerosis-associated molecules) upregulated by repetitive hypoxemia in OSA and may be involved in the development of the atherogenic process in OSA. [ 10 11 12 13 14 ]…”

Comparison of Buyang Huanwu Granules and Naoxintong Capsules in Treatment of Stable Angina Pectoris: Rationale and Design of a Randomized, Double-blind, Multicenter Clinical Trial

“…Coronary artery disease (CAD), a common cardiovascular disease, is the leading cause of morbidity and mortality worldwide [4,5]. Angina pectoris is the most common symptom of CAD, and a major cause of disability.…”