Correlation of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function in Chinese patients with chronic hepatitis C virus infection

Liu, Zhengwen; Zhang, Ni; Han, Qunying; Zeng, Juntao; Chu, Yangyang; Qiu, Jianming; Wang, Yawen; Ma, Lie-Ting; Wang, Xiaoqin

doi:10.3748/wjg.v11.i22.3357

Cited by 22 publications

(17 citation statements)

References 50 publications

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“…Although leptin regulates feeding behavior, individuals who are obese have high levels of leptin without the expected anorexic responses, due to leptin resistance 8 . Furthermore, because leptin plays a role in host defense mechanisms, the plasma levels of leptin have been reported to increase in infections 30 and in response to proinflammatory stimuli, such as lipopolysaccharide (LPS) and TNF‐α 31 . A recent investigation demonstrated that leptin is able to enhance Prevotella intermedia LPS‐induced TNF‐α production 32 .…”

Section: Discussionmentioning

confidence: 99%

Local and Circulating Levels of Adipocytokines in Obese and Normal Weight Individuals With Chronic Periodontitis

Zimmermann

Bastos

Gonçalves

et al. 2013

Journal of Periodontology

128

149

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Section: Discussionmentioning

confidence: 99%

Local and Circulating Levels of Adipocytokines in Obese and Normal Weight Individuals With Chronic Periodontitis

Zimmermann

Bastos

Gonçalves

et al. 2013

Journal of Periodontology

128

149

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“…Serum leptin levels were higher in CHC patients than controls, 53 and associated with the severity of fi brosis. 54 Serum leptin levels correlated with hepatic steatosis in patients infected with hepatitis C virus genotype 3 but not genotype 1.…”

Section: Leptin and Liver Diseasesmentioning

confidence: 96%

Adipocytokines and liver disease

2008

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Adipose tissue is a massive source of bioactive substances known as adipocytokines, including tumor necrosis factor (TNF)-alpha, resistin, leptin, and adiponectin. Recent advances in medical research view obesity as a chronic low-grade inflammatory state. Hypertrophied adipocytes in obesity release chemokines that induce macrophage accumulation in adipose tissue. Accumulated macrophages in obese adipose tissue produce proinflammatory cytokines and nitric oxide, and these inflammatory changes induce adipocytokine dysregulation. The latter is characterized by a decrease in insulinsensitizing and anti-inflammatory adipocytokines, and an increase in proinflammatory adipocytokines. Adipocytokine dysregulation induces obesity-related metabolic disorders, the so-called metabolic syndrome. Metabolic syndrome is a cluster of metabolic abnormalities, including diabetes mellitus, hypertension, hyperlipidemia, and nonalcoholic steatohepatitis (NASH). Recent studies have revealed that obesity is an independent risk factor for chronic liver diseases, such as NASH, alcoholic liver disease, chronic hepatitis C, and hepatocellular carcinoma. A common mechanism underlying these hepatic clinical states is thought to be adipocytokine dysregulation. In this review, we discuss the association of adipocytokines, especially leptin, adiponectin, TNF-alpha, and resistin, with liver diseases.

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“…Pooling data from studies [24,28,35,38] with 1507 participants showed that there was a linear dose-response relationship between AdipoQ levels and HCC risk ( Pnon−linearity = 0.233). We de ned the increment in 1 µg/ml AdipoQ levels as a unit to show the trend more clearly.…”

Section: Dose-response Of Circulating Adipoq Leptin Levels and Hcc Riskmentioning

confidence: 99%

Association of Circulating Leptin and Adiponectin with Risk and Prognosis of Hepatocellular carcinoma: A Combination of Traditional, Survival and Dose-response Meta-analysis

Li-long

Yuan

et al. 2020

Preprint

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Background: The association between leptin, adiponectin levels and the risk and prognosis of hepatocellular carcinoma has been investigated by a growing number of studies, but the results were controversial. Methods: We performed the meta-analysis to assess the relationships between leptin, adiponectin levels and the risk and prognosis of hepatocellular carcinoma (CRD42020195882). Through June 14, 2020, PubMed, Cochrane Library, Embase databases, Clinicaltrials, and Opengrey was searhed, including references of qualifying articles. Titles, abstracts, and articles were reviewed by at least 2 independent readers. Stata 16.0 was used to calculate statistical data. Results: Thirty studies were included in this meta-analysis and results showed that hepatocellular carcinoma group has significantly higher leptin levels than the cancer-free control group (SMD = 1.83, 95% CI (1.09, 2.58), P = 0.000) , the healthy control group (SMD = 4.32, 95% CI (2.41, 6.24), P = 0.000) and the cirrhosis group (SMD = 1.85, 95% CI (0.70, 3.01), P = 0.002). Hepatocellular carcinoma group has significantly higher adiponectin levels than the the healthy control group (SMD = 1.57, 95% CI (0.37, 2.76), P = 0.010), but no statistical difference compared with the cancer-free control group (SMD = 0.24, 95% CI (-0.35, 0.82), P = 0.430) and the cirrhosis group (SMD = -0.51, 95% CI (-1.30, 0.29), P= 0.213). The leptin rs7799039 polymorphism was associated with an increased the risk of hepatocellular carcinoma (G vs A: OR = 1.28, 95% CI (1.10, 1.48), P = 0.002). There were linear relationships between adiponectin levels and the risk of hepatocellular carcinoma (OR = 1.066, 95% CI (1.03, 1.11), P = 0.001). In addition, the results showed that high/positive expression of adiponectin was significantly related to lower overall survival in hepatocellular carcinoma patients (HR = 1.70, 95% CI (1.22, 2.37), P = 0.002); however, there was no significantly association between the leptin levels and overall survival (HR = 0.92, 95% CI (0.53, 1.59), P = 0.766). Conclusion: The study shows that high leptin levels were associated with a higher risk of hepatocellular carcinoma. Adiponectin levels were proportional to hepatocellular carcinoma risk, and were related to the poor prognosis.

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Correlation of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function in Chinese patients with chronic hepatitis C virus infection

Abstract: HCV infection interferes with fat and lipid metabolism in patients with chronic HCV infection and leptin may play a role in hepatosteatosis.

Cited by 22 publications

References 50 publications

Local and Circulating Levels of Adipocytokines in Obese and Normal Weight Individuals With Chronic Periodontitis

Local and Circulating Levels of Adipocytokines in Obese and Normal Weight Individuals With Chronic Periodontitis

Adipocytokines and liver disease

Association of Circulating Leptin and Adiponectin with Risk and Prognosis of Hepatocellular carcinoma: A Combination of Traditional, Survival and Dose-response Meta-analysis

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