Local and Circulating Levels of Adipocytokines in Obese and Normal Weight Individuals With Chronic Periodontitis

Abstract

Periodontitis mainly influenced the circulating levels of resistin and adiponectin, whereas both obesity and periodontitis affected the circulating levels of leptin in favor of proinflammation. In addition, obesity upregulated the local levels of TNF-α.

The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy

“…However, sample size could not be calculated because accurate data on GCF vaspin and omentin levels was lacking. Instead, we used the TNF-α levels reported by Zimmerman et al (24) (minimum difference of 0.65 with 0.51 pg standard deviation between obese and non-obese periodontitis patients) to determine the required sample size for appropriate study power. For TNF-α levels, a sample of 14 participants was used in every group to accommodate a type II error level of β of 0.20 (80% power) and a two-tailed type I error level of α of 0.05 (5% probability).…”

“…Obesity was evaluated based on the BMI, which is the body weight divided by height in square meters (kg/m 2 ), and the WHR, which is the ratio of waist-to-hip circumference (cm/cm) (24). The World Health Organization has specified six weight categories on the basis of BMI: underweight (BMI < 18.5 kg/m (25).…”

“…Furthermore, a WHR ≥ 0.85 (females) and ≥0.90 (males) is indicative of abdominal obesity (25). Individuals with a BMI ≥ 20 but <25 kg/m 2 and a WHR below obesity level were placed in the normal weight group, while individuals with a BMI ≥ 30 but <40 kg/m 2 and a WHR greater than the obesity level were placed in the obese group (24).…”

Association Between Gingival Crevicular Fluid Leptin Levels and Periodontal Status – A Biochemical Study on Indian Patients

“…Although this relationship needs further investigation, periodontists should counsel obese patients regarding the complications of their obesity to improve their periodontal status. Zimmermann et al, [21] had further evaluated the local and circulating levels of adipocytokines (resistin, adiponectin, leptin, tumor necrosis factor {TNF}-α, and interleukin {IL}-6) in individuals who were obese and individuals who were normal weight (NW) with chronic periodontitis (CP). Periodontitis mainly influenced the circulating levels of resistin and adiponectin, whereas both obesity and periodontitis affected the circulating levels of leptin in favor of proinflammation.…”

Obesidade e saúde bucal: impacto da obesidade sobre condições bucais

“…Algumas citocinas produzidas por células adiposas e macrófagos, encontrados no processo inflamatório, são de grande relevância no desenvolvimento da periodontite 29 . A leptina e resistina, adipocinas que parecem estar também envolvidas nessa relação, têm a função de manutenção e ativação do processo inflamatório, e tem uma relação com a secreção de citocinas pró-inflamatórias 30 . Em pacientes obesos e com doença periodontal, os níveis de proteína c-reativa (PCR) encontram-se o padrão alimentar 19 .…”