Correlation Study of Pulmonary Embolism and High‐density Lipoprotein Cholesterol

Wang, Yupeng; Wang, Ping; Li, Hongwei

doi:10.1002/clc.20692

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…53 ). Several studies have shown that HDL-C levels correlate inversely with different pathological modes of thrombosis ( 54,55 ). HDL can oppose LDL induction of platelet aggregation, serotonin release, and thromboxane B2 production ( 56 ), and it can block ox-LDL inhibition of nitric oxide synthase ( 57 ).…”

Section: Hdl Functional Diversity Matches Its Proteomic Diversitymentioning

confidence: 99%

Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond

Shah

Tan

Long

et al. 2013

Journal of Lipid Research

324

302

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Section: Hdl Functional Diversity Matches Its Proteomic Diversitymentioning

confidence: 99%

Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond

Shah

Tan

Long

et al. 2013

Journal of Lipid Research

324

302

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“…High-density lipoprotein cholesterol-C may reduce the risk of atherosclerotic lesions by the reverse cholesterol transport, anti-inflammatory and antioxidant effects, and attenuation of endothelial dysfunctions. 3 In previous studies, it has been shown that serum HDL-C levels are significantly low in PE 11,22,23 and elevated serum HDL-C levels might decrease the risk of PE in postmenapausal women. 12 A recent study, by Wang et al showed that pulmonary arterial trunk embolism is negatively correlated with the level of HDL-C. 23 In contrast, other previous studies found no association between HDL-C and PE.…”

Section: Discussionmentioning

confidence: 95%

“…3 In previous studies, it has been shown that serum HDL-C levels are significantly low in PE 11,22,23 and elevated serum HDL-C levels might decrease the risk of PE in postmenapausal women. 12 A recent study, by Wang et al showed that pulmonary arterial trunk embolism is negatively correlated with the level of HDL-C. 23 In contrast, other previous studies found no association between HDL-C and PE. 3,16,4 Chamberlain et al found low HDL-C does not appear to be an important VTE risk factor.…”

Section: Discussionmentioning

confidence: 98%

Homocysteine and Serum-Lipid Levels in Pulmonary Embolism

Karalezli

Parlak

Kanbay

et al. 2011

Clin Appl Thromb Hemost

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Pulmonary embolism (PE) is a fatal disease that arises from genetic and environmental factors. There is little evidence for low high-density lipoprotein cholesterol (HDL-C) with hyperhomocysteinemia to lead to PE. Therefore, we evaluated homocysteine levels and lipid profile in PE patients and to display risk for PE. Forty six patients with proven PE and 46 healthy controls were included in the study. Homocysteine and serum lipid levels were calculated and compared in both groups. There were no significant differences between two groups in terms of total cholesterol, triglyceride, and low-density lipoprotein cholesterol. In PE group, HDL-C levels were found significantly lower in comparison to the control group (P = .004). Mean homocysteine levels were significantly higher in PE group than in the control group (P = .001). High-density lipoprotein cholesterol levels were significantly low in which homocysteine levels were high in the PE group. We thought that low HDL-C level with hyperhomocysteinemia is susceptible to PE.

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“…Wang et al also reported that pulmonary arterial trunk embolism was negatively correlated with the level of HDL cholesterol (11). The risk factors for VTE recurrence during anticoagulation include immobilization, cancer, and chronic obstructive pulmonary disease.…”

Section: Discussionmentioning

confidence: 96%

Effect of HDL level on thrombus resolution in pulmonary embolism

Er¹,

Aykun²,

Karalezli³

et al. 2017

Med J Islamic World Acad Sci

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SUMMARYRecurrent thrombosis and lack of enough resolution of pulmonary emboli may lead to the development of chronic thromboembolic pulmonary hypertension. The purpose of this study was to investigate the correlation of initial, 10th-day and 6th-month lipid profile values with the changes in the pulmonary artery obstruction index in patients with pulmonary embolism (PE).Twenty-eight patients diagnosed with PE were included in the study. Fifteen of them were treated using thrombolytic agents, and 13 of them were treated using conventional treatment. Pulmonary artery obstruction index of all patients was calculated after they underwent pulmonary computed tomography (CT) angiography. Arterial blood gas analysis and echocardiography were performed and lipid profile levels were analyzed during initial diagnosis and repeated on the 10th day and 6th month of the treatment.A significant positive correlation was found between HDL and percent change in pulmonary artery obstruction index. The patients with a high level of HDL showed better emboli resolution (P = 0.013). Higher age and lower percent change in the 10th-day pulmonary artery obstruction showed a positive correlation with the persistence of embolism in the 6th month.Patients with lower HDL levels are at risk of recurrent embolic events and even chronic thromboembolic pulmonary hypertension, which can be prevented by HDL augmentation.

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Correlation Study of Pulmonary Embolism and High‐density Lipoprotein Cholesterol

Cited by 9 publications

References 26 publications

Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond

Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond

Homocysteine and Serum-Lipid Levels in Pulmonary Embolism

Effect of HDL level on thrombus resolution in pulmonary embolism

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