Correlations between serum adipocytokine concentrations, disease stage, radiological status and total body fat content in the patients with primary knee osteoarthritis

Abstract

Purpose The study was designed to investigate whether serum concentrations of leptin, resistin and adiponectin in obese and normal-weight patients with primary knee osteoarthritis (OA) correlate with clinical and radiological stages of the disease and percentage of total body fat. Methods Seventy-three patients with knee OA, divided into obese and normal-weight groups, were clinically evaluated according to the Knee Society Score (KSS), and radiologically assessed using Kellgren and Lawrence scale. The percentage of total body fat and some anthropometric data were also given. Serum leptin, resistin and adiponectin concentrations were measured by Elisa and were correlated with the clinical, radiological and anthropometric parameters. Results Leptin concentrations were significantly higher (p = 0.001) in the obese patients and positively correlated (R = 0.63) with radiologically assessed OA grade, but only in the normal-weight group. Resistin and adiponectin concentrations were identical in obese and normal-weight patients and negatively correlated (R = −0.41) with the clinical status of obese patients. In both groups, percentage of total body fat positively correlated (R = 0.29 and R = 0.53 for obese and normal-weight respectively) with radiologically assessed OA grade. However, no correlations were found with clinical status of the patients. Conclusions It was found that in the obese patients with knee OA, increased percentage of total body fat and elevated serum leptin concentration might favour the advancement of clinical but not radiologically assessed changes in the joint structures, while in normal-weight patients it correlates only with radiologically assessed changes but does not affect to an appreciable extent the clinical status of the patients.

Clinical and ultrasonographic features associated to response to intraarticular corticosteroid injection. A one year follow up prospective cohort study in knee osteoarthritis patient with joint effusion

“…Thus, patients with high scores in the Lequesne index could not be good candidates for a local pain technique such as IACI, unless this point warrants more study. Different data exists in the literature supporting the negative effect of body fat mass or obesity in knee OA[ 42 , 43 ], but to our knowledge, this is the first time when percentage of body fat mass has been found to be associated to pain at one year. Differences in gender exist in the literature regarding pain in knee OA [ 44 , 45 ].…”

Management of osteoarthritis - biological approaches: current concepts

“…The limited therapeutic benefits of HA and corticosteroids in the long term have given rise to novel, innovative biological intra-articular injection and cell therapies, specifically platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), adipose-derived mesenchymal stem cells (AD-MSCs), antitumour necrosis factor agents, interleukin (IL)-1 receptor agonists and gene therapies. These orthobiologic agents represent a shifting paradigm as the pathophysiology of OA continues to be better understood to target complex cellular signalling pathways that play a role in disease progression 12–14. To date, the existing human literature is most robust regarding PRP and BMAC, with few early studies published regarding AD-MSCs.…”

A Complex Relationship between Visfatin and Resistin and microRNA: An In Vitro Study on Human Chondrocyte Cultures

“…In human OA chondrocyte cultures, resistin induces the expression of different pro-inflammatory cytokines and chemokines, as well as of metalloproteinases (MMP)-1, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4 [12]. Serum levels of resistin are increased in patients with OA of the hand [13,14] and in serum and synovial fluid of patients with knee OA [15,16,17].…”