Cortical thickness abnormality in juvenile myoclonic epilepsy

Extrafrontal structural changes in juvenile myoclonic epilepsy: A topographic analysis of combined structural and microstructural brain imaging

“…However, these areas did not overlap with regions showing abnormal cortical shape in their previous study [10]. This discrepancy may reflect differences in analytic methodology, but the results still support the presence of underlying microstructural changes that extend beyond the thalamofrontal regions from disease chronicity [5,25] or brain maturational alterations [26].…”

The emergence of abnormal hypersynchronization in the anatomical structural network of human brain

“…However, for patients with SW epileptic seizures, it is very possible that the relative connectivity strength and fiber length are varied. Recently, cross-sectional studies of children, adolescents and young adults with idiopathic generalized epilepsies (IGE) including childhood absence and juvenile myoclonic epilepsy have reported distributed patterns of abnormality predominantly affecting thalamus and frontal lobe (Betting et al, 2006a(Betting et al, , 2006b(Betting et al, , 2006cCaplan et al, 2009aCaplan et al, , 2009bde Araujo et al, 2009;Kim et al, 2007;Pardoe et al, 2008;Pulsipher et al, 2009;Tae et al, 2006Tae et al, , 2008Tosun et al, 2011). Collectively, these studies clearly indicate a neurodevelopmental contribution to anatomic abnormalities that have been observed in adults with these syndromes of epilepsy ).…”

Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy: 3D multivoxel spectroscopy study

“…The finding of altered hippocampal metabolism could be a consequence of propagation of epileptiform discharges typically generated in frontotemporal thalamocortical circuits. Similarly, decreased NAA could correspond to decreased cortical thickness of temporal lobes in JME patients, found in voxelbased morphometry studies [18,19].…”