Cortical thickness and subcortical structure volume abnormalities in patients with major depression with and without anxious symptoms

Zhao, Ke; Liu, Haiyan; Yan, Rui; Lu, Hua; Chen, Yu; Shi, Jiabo; Lü, Qing; Yao, Zhijian

doi:10.1002/brb3.754

Cited by 64 publications

(38 citation statements)

References 50 publications

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“…While AD is common in clinical practice, an in-depth understanding toward its neuromechanism is limited. Structural magnetic resonance imaging studies found that AD patients had brain structural abnormalities in the cortical-limbic circuit, which were involved in emotion regulation (14)(15)(16). Similar brain abnormalities also have been found in functional magnetic resonance imaging (fMRI) studies (17)(18)(19)(20)(21).…”

Section: Introductionsupporting

confidence: 52%

Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression

et al. 2020

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Background: Anxious depression (AD), which is generally recognized as a common clinical subtype of major depressive disorder (MDD), holds distinctive features compared with unanxious depression (UAD). However, the neural mechanism of AD still remains unrevealed. To give insight to it, we compared resting-state functional magnetic resonance amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) between AD and UAD patients. Method: The data were collected from 60 AD patients, 38 UAD patients, and 60 matched healthy controls. The ALFF and seed-based FC were examined. Pearson correlations were computed between ALFF/FC and clinical measures. Results: In Comparison with the UAD group, the ALFF value of the right orbital part of middle frontal gyrus (RO-MFG) decreased in AD group. Specifically, the ALFF values of the RO-MFG were negatively correlated with retardation factor scores in AD group (r =-0.376, p = 0.003). Conclusions: AD patients exhibited disturbed intrinsic brain function compared with UAD patients. The decreased activity of the RO-MFG is indicative of the alterations involved in the neural basis of AD.

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Section: Introductionsupporting

confidence: 52%

Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression

et al. 2020

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“…In summary, although brainstem abnormality is found to be associated with the promotion of idiopathic RBD from experimental and clinical perspectives (Scherfler et al, 2011;Hanyu et al, 2012), there are no apparent volume changes of GM in the brainstem in PD patients with RBD compared with those without RBD. Previous studies have demonstrated the strong association of reduced GM volume changes in the right STG with weakened spatial processing (Ellison et al, 2004;Gharabaghi et al, 2006;Shah-Basak et al, 2018), narcolepsy (Joo et al, 2009;Weng et al, 2015), impaired emotion processing to support social interactions (Muller et al, 2008;Pan et al, 2015;Van de Vliet et al, 2018;Zhang et al, 2018), violent behaviors (Zhang et al, 2019), and some psychiatric disorders (Moreira et al, 2017;Zhao et al, 2017;Wang et al, 2018). Consistent with our result, sleep disorders and nocturnal violence in PD patients with RBD can be partially explained by GM volume reduction in the right STG.…”

Section: Discussionsupporting

confidence: 91%

Gray Matter Alterations in Parkinson's Disease With Rapid Eye Movement Sleep Behavior Disorder: A Meta-Analysis of Voxel-Based Morphometry Studies

Yang

Chang

Liang

et al. 2020

Front. Aging Neurosci.

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Background: Gray matter (GM) alterations in Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD) have been demonstrated in many neuroimaging studies using voxel-based morphometry (VBM). However, the inconsistent findings between studies cannot be applied to clinical practice as a neuroimaging biomarker. We performed a meta-analysis of VBM studies at a whole-brain level to investigate GM differences between PD patients with and without RBD. Methods: A systematic search was conducted in PubMed, Embase, and Web of Science from inception to November 2019 to identify eligible VBM studies. We adopted the latest Seed-based d Mapping with Permutation of Subject Images technique to quantitatively estimate the difference of regional GM volume between PD patients with and without RBD. Results: We included five studies comprising 105 PD patients with RBD and 140 PD patients without RBD. The pooled meta-analysis revealed that PD patients with RBD showed a significant reduction of GM volume in the right superior temporal gyrus (STG) compared with those without RBD. This result was confirmed to be robust by the jackknife sensitivity analysis. Conclusion: Our finding shows significantly and robustly reduced GM volume in the right STG in PD patients with RBD, preliminarily suggesting the association of GM atrophy in this brain region with the occurrence of RBD in PD patients.

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“…Among these regions, the right hippocampus showed the largest LSV changes (Table 2), which correlated with the severity of depression (Table 3). Imaging studies on the subcortical volumes in patients with depression and their relationship with depression severity have reported inconsistent results, but the hippocampal volumetric decrease has been a consistent finding (Chen et al, 2020; Schmaal et al, 2016; Zhao et al, 2017).…”

Section: Discussionmentioning

confidence: 97%

Local shape volume alterations in subcortical structures of suicide attempters with major depressive disorder

Kang

Shin

Han

et al. 2020

Human Brain Mapping

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Suicide is among the most important global health concerns; accordingly, an increasing number of studies have shown the risks for suicide attempt(s) in terms of brain morphometric features and their clinical correlates. However, brain studies addressing suicidal vulnerability have been more focused on demonstrating impairments in cortical structures than in the subcortical structures. Using local shape volumes (LSV) analysis, we investigated subcortical structures with their clinical correlates in depressed patients who attempted suicide. Then we compared them with depressed patients without a suicidal history and age‐ and sex‐matched healthy controls (HCs; i.e., 47 suicide attempters with depression, 47 non‐suicide attempters with depression, and 109 HCs). Significant volumetric differences were found between suicidal and nonsuicidal depressed patients in several vertices: 16 in the left amygdala; 201 in the left hippocampus; 1,057 in the left putamen; and 140 in the left pallidum; 1 in the right pallidum; and 6 in the bilateral thalamus. These findings indicated subcortical alterations in LSV in components of the limbic–cortical–striatal–pallidal–thalamic circuits. Moreover, our results demonstrated that the basal ganglia was correlated with perceived stress levels, and the thalamus was correlated with suicidal ideation. We suggest that suicidality in major depressive disorder may involve subcortical volume alterations.

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Cortical thickness and subcortical structure volume abnormalities in patients with major depression with and without anxious symptoms

Abstract: Background: Anxious depression is one of the common subtypes of major depressive

Cited by 64 publications

References 50 publications

Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression

Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression

Gray Matter Alterations in Parkinson's Disease With Rapid Eye Movement Sleep Behavior Disorder: A Meta-Analysis of Voxel-Based Morphometry Studies

Local shape volume alterations in subcortical structures of suicide attempters with major depressive disorder

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