Corticospinal Tract Pre-Wallerian Degeneration

Domi, Trish; deVeber, Gabrielle; Shroff, Manohar; Kouzmitcheva, Elizabeth; MacGregor, Daune; Kirton, Adam

doi:10.1161/strokeaha.108.529958

Cited by 87 publications

(40 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Univariate analyses failed to detect any differences. These results, obtained at the acute stage, are in line with previous studies carried out at the subacute or chronic phases [3,2,4]. Our results suggest that spatially regularized SVM might be useful to analyze MR images acquired in clinical routine as soon as 24 hours post stroke onset.…”

Section: Resultssupporting

confidence: 91%

“…The location of the lesions has been suggested to represent a better predictor than their global volume [2]. At the subacute or chronic phases, previous studies have shown that damages to the corticospinal tract (CST) [3] and lesions to the primary sensorimotor cortex [2,4] correlated with poor motor outcome. At the acute stage, regional changes in the apparent diffusion coefficients (ADC) were suggested as early quantitative indices of regional irreversible ischemic damage [5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spatially Regularized SVM for the Detection of Brain Areas Associated with Stroke Outcome

Cuingnet

Rosso

Lehericy

et al. 2010

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2010

View full text Add to dashboard Cite

Abstract. This paper introduces a new method to detect group differences in brain images based on spatially regularized support vector machines (SVM). First, we propose to spatially regularize the SVM using a graph encoding the voxels' proximity. Two examples of regularization graphs are provided. Significant differences between two populations are detected using statistical tests on the margins of the SVM. We first tested our method on synthetic examples. We then applied it to 72 stroke patients to detect brain areas associated with motor outcome at 90 days, based on diffusion-weighted images acquired at the acute stage (one day delay). The proposed method showed that poor motor outcome is associated to changes in the corticospinal bundle and white matter tracts originating from the premotor cortex. Standard mass univariate analyses failed to detect any difference.

show abstract

Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Spatially Regularized SVM for the Detection of Brain Areas Associated with Stroke Outcome

Cuingnet

Rosso

Lehericy

et al. 2010

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2010

View full text Add to dashboard Cite

show abstract

“…Previous studies on diffusion-weighted imaging in term born infants with arterial stroke showed that visually detected abnormalities in signal intensity at the level of the PLIC and cerebral peduncle are suggestive of pre-Wallerian degeneration. They were noted to be predictive of subsequent Wallerian degeneration and an adverse motor outcome (14,18,19). The present study adds that changes in FA after PVHI can already be visually detected at a very early age.…”

Section: Discussionsupporting

confidence: 61%

“…Previous studies have shown that asymmetries in FA of the CST after PVHI and arterial stroke at TEA indicate CST injury that is associated with the development of USCP (14)(15)(16). The present study adds that in preterm infants with a PVHI, asymmetry in FA can be detected within weeks after the onset of PVHI reflecting early alterations in CST integrity that relate to later motor outcome.…”

Section: Discussionmentioning

confidence: 99%

Neonatal DTI early after birth predicts motor outcome in preterm infants with periventricular hemorrhagic infarction

et al. 2015

View full text Add to dashboard Cite

Background:To determine the association between early neonatal diffusion tensor imaging (DTI) and the development of unilateral spastic cerebral palsy (USCP) in preterm infants with periventricular hemorrhagic infarction (PVHI). Methods: Preterm infants with PVHI were assessed with early (≤4 wk after birth) and term-equivalent age MRI-DTI. Involvement of corticospinal tracts was assessed by visual assessment of the posterior limb of the internal capsule (PLIC) on DTI (classified asymmetrical, equivocal, or symmetrical) and by an atlas-based approach calculating fractional anisotropy asymmetry index in the PLIC. Motor outcome was assessed at ≥15 mo corrected age. results: Seven out of 23 infants with PVHI developed USCP. Their PLIC was visually scored as asymmetrical in 6 and equivocal in 1 on the early DTI. Thirteen out of 16 infants with a symmetrical motor development had a symmetrical PLIC on early DTI, the remaining 3 were equivocal. All infants with USCP had a fractional anisotropy asymmetry index of >0.05 (optimal cut-off value) on early DTI. In infants with a symmetrical motor development (n = 16), 14 had an asymmetry index ≤0.05 while 2 had an index >0.05. conclusion: DTI in preterm infants with PVHI within a few weeks after birth is associated with later motor development. P eriventricular hemorrhagic infarction (PVHI) is a serioustype of brain injury that occurs in around 1-3% of preterm infants with a gestational age below 37 wk (1-3). It is a complication of a germinal matrix hemorrhage that develops due to impaired venous drainage of the medullary veins in the periventricular white matter and may have an adverse effect on corticospinal tract (CST) development (4). PVHI leads in about 50-85% of infants to, mainly unilateral, spastic cerebral palsy (USCP) (2,3,5). The diagnosis is made with cranial ultrasound (cUS) and prediction of cerebral palsy is possible in most but not all infants taken the site and size of the lesion into account (5).MRI studies performed at term-equivalent age (TEA) will reliably predict motor outcome with asymmetry in myelination of the posterior limb of the internal capsule (PLIC) due to Wallerian degeneration being almost invariably associated with the development of USCP (6).Diffusion tensor imaging (DTI) allows the study of microstructural properties of the white matter (7). To the best of our knowledge, it has not yet been studied whether early disturbances in CST integrity shortly after the onset of PVHI relate to later development of USCP. In addition, the prognostic value of DTI for early prediction of USCP in infants with PVHI is still unknown.The aim of this study was to determine the association between MRI-DTI within 4 wk after birth and the development of USCP in preterm infants with PVHI. RESULTS PatientsThe clinical characteristics and motor outcome of the study group (n = 23) are summarized in Table 1. The infants who developed cerebral palsy (n = 7, 30%) all had USCP. Cranial Ultrasound FindingsIn 16 infants with a normal motor development, the cUS on which t...

show abstract

“…By contrast, function-specific imaging biomarkers may have greater potential to predict outcomes. The leading example is early diffusion imaging changes in the descending corticospinal tract, which appear to correlate well with motor outcome in neonatal (e.g., cerebral palsy), childhood, and adult stroke (12,13). We have shown recently, using MRI in a neonatal model of hypoxia-ischemia, that similar to changes in the descending corticospinal tract in human infants, there are acute (by 24 h) increases in T 2 and decreases in the apparent diffusion coefficient (ADC) of water, consistent with early Wallerian degeneration (14).…”

mentioning

confidence: 99%

Magnetization transfer and diffusion imaging of acute axonal damage in the cerebral peduncle following hypoxia–ischemia in neonatal rats

et al. 2012

Self Cite

View full text Add to dashboard Cite

Background: Magnetic resonance imaging (MRI) of axonal degenerative changes in the cerebral peduncle of the corticospinal tract following cerebral hypoxic-ischemic damage might distinguish infants most appropriate for receiving prompt treatment. The optimal MRI sequence for very early diagnosis of axonal degenerative changes is unknown. We hypothesized that magnetization transfer ratio (MTR) imaging would be more sensitive than traditional MRI, e.g., T 2 or diffusion weighted imaging. Methods: Transient unilateral cerebral hypoxia-ischemia was produced in the neonatal rat followed by MRI of changes in T 2 , the apparent diffusion coefficient (aDc) of water, and MTR, with a focus on the parietal cortex (an ischemic damaged region) and the cerebral peduncle (remote within the corticospinal tract). Rats were imaged at 2 h, 1 d, or 1 wk postinsult. results: In the cerebral peduncle, MTR and T 2 responded similarly, with alterations occurring ipsilaterally at 1 d postinsult. aDc was most sensitive for detecting changes as early as 2 h postinsult, and this corresponded to a reduced staining of axonal filaments ipsilaterally. conclusion: MTR and T 2 imaging have comparable sensitivity for distinguishing early axonal damage in the cerebral peduncle. aDc imaging is highly sensitive for detecting early disruption of corticospinal axons, supporting its potential hyperacute diagnostic use clinically.

show abstract

Corticospinal Tract Pre-Wallerian Degeneration

Cited by 87 publications

References 29 publications

Spatially Regularized SVM for the Detection of Brain Areas Associated with Stroke Outcome

Spatially Regularized SVM for the Detection of Brain Areas Associated with Stroke Outcome

Neonatal DTI early after birth predicts motor outcome in preterm infants with periventricular hemorrhagic infarction

Magnetization transfer and diffusion imaging of acute axonal damage in the cerebral peduncle following hypoxia–ischemia in neonatal rats

Contact Info

Product

Resources

About