Corticosteroids in experimental fat embolization

Kreis, Wilmont R.; Lindenauer, S. Martin; Dent, T.

doi:10.1016/0022-4804(73)90140-6

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…Rokkanen [39] was the first to use steroids prophylactically in an attempt to reduce the incidence of FES following massive trauma. Kreis [40] demonstrated that corticosteroids improved oxygenation and decreased the pathologic changes seen on pulmonary biopsies in experimental animals. Gregory [41] showed that the steroids must be given prior to the free fatty acid injection to be of benefit ( Table 2).…”

Section: Steroids As a Prophylactic Agent In Fat Embolism Syndromementioning

confidence: 99%

Steroids in the Prophylaxis of Fat Embolism Syndrome

Shivanna¹

2012

J Aquac Res Development

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With complex and extensive pharmacological effects, corticosteroids are widely used in many clinical situations. Improving the course and outcome of patients with fat embolism syndrome presents a challenge. By understanding the immune status of a patient, physicians can consider manipulating proinflammatory systems more rationally. In this context, corticosteroids could be a therapeutic tool in the armamentarium against fat embolism syndrome. The inflammatory mechanisms are continuous and cyclic, sometimes causing deterioration or improvement of lung function. Great caution must be taken in clinical situations where administration of corticosteroids is considered contraindicated such as systemic fungal infection, hypersensitivity to the drug, intramuscular injection in idiopathic thrombocytopenia purpura, vaccination with live virus. This article reviews the mechanisms of action of corticosteroids and the results of clinical studies regarding the use of corticosteroids in fat embolism syndrome.

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Section: Steroids As a Prophylactic Agent In Fat Embolism Syndromementioning

confidence: 99%

Steroids in the Prophylaxis of Fat Embolism Syndrome

Shivanna¹

2012

J Aquac Res Development

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“…56 Several studies have reported improved oxygenation during the first 48 hours of lung injury induced by oleic acid in dogs pretreated with methylprednisolone. [57][58][59] Most recently, Cheney and associates gave dogs 30 ml/kg of methylprednisolone 3 and 24 hours after oleic acid infusion. 60 A smaller venous admixture and better blood gases were noted at 72 hours in the treated animals compared with controls in this study postmortem examination at five days also revealed that the treated animals had less pulmonary edema and a striking proliferation of Type II alveolar cells.…”

Section: Aspiration Pneumoniamentioning

confidence: 99%

Corticosteroids and Antibiotics in Adult Respiratory Distress Syndrome: A Review

Luce¹,

Pierson²

1981

Semin Respir Crit Care Med

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“…However, there is little information on the effect of corticosteroids in PE. In models of fat embolism, steroids counteract the effect of mediators released by platelets, and improve the ventilation–perfusion ratio and the PaO 2 16 …”

Section: Introductionmentioning

confidence: 99%

“…In models of fat embolism, steroids counteract the effect of mediators released by platelets, and improve the ventilation-perfusion ratio and the PaO2. 16 It is believed that platelets could play an important role in the physiopathology of PE. Platelet activation and aggregation are key events in both thrombus formation and vasoconstriction after acute PE.…”

Section: Introductionmentioning

confidence: 99%