Corticosteroids in Pregnancy for Preventing RDS: Overview of Systematic Reviews

Uggioni, Maria Laura Rodrigues; Colonetti, Tamy; Grande, Antônio José; Cruz, Mateus; Rosa, Maria Inês da

doi:10.1007/s43032-020-00425-x

Cited by 4 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Very few major adverse effects have been seen. 17,18 Its benefit is not only limited to babies less than 34 weeks of gestation but also been found to be beneficial in late preterm delivery. 19,20 The response to corticosteroids has been found to be present even after a single dose.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Surfactant replacement therapy for respiratory distress syndrome in preterm babies

Kansakar

Shrestha²,

Prajapati

et al. 2022

J. Nepal Paedtr. Soc.

View full text Add to dashboard Cite

Introduction: Surfactant is an important treatment modality in preterm babies with respiratory distress syndrome leading to decrease in mortality, morbidity and cost of treatment. Experiences on surfactant therapy in Nepal are scarce. This study was conceptualised to find the use and immediate outcome of surfactant therapy in preterm babies in a tertiary care hospital in Nepal. Methods: A cross-sectional study was done in preterm babies who received surfactant over period of five years at neonatal / pediatric intensive care unit at Patan Hospital, Lalitpur, Nepal. After approval from Institutional review committee, information on gestational age, sex, birth weight, doses of dexamethasone, doses and time surfactant delivery, complications and immediate outcome was retrieved from the files. Comparison between early and late rescue group was done. Data was analysed using SPSS 16. Results: Twelve babies (11.2%) needed a repeat dose of surfactant. Only 12 (11.2%) babies received early rescue surfactant. About 53 (49.5%) babies developed complications with hypotension being the most common seen in 38 (35.5%) babies. Complications were 75% and 46% in the early and late rescue group respectively (p - 0.22). The mortality was inversely proportional to the gestational age (p - 0.002) and birth weight (p < 0.05). Mortality was 16% in both the groups but the deaths related to complications of surfactant was all in the late rescue group. Conclusions: Complications were more in early rescue group and mortality was similar in both the groups, but mortality related to complications of surfactant was all in the late rescue group. Complications of surfactant therapy and mortality were inversely proportional to the gestational age and birth weight.

show abstract

Section: Discussionmentioning

confidence: 99%

Outcome of Surfactant replacement therapy for respiratory distress syndrome in preterm babies

Kansakar

Shrestha²,

Prajapati

et al. 2022

J. Nepal Paedtr. Soc.

View full text Add to dashboard Cite

show abstract

“…In a similar study [14] (n = 5) administered dexamethasone between days 315 and 317, reduced mean gestation to 322 days versus 335 for controls. Dexamethasone, a glucocorticoid accelerates fetal maturation (including lung maturation, essential for capability with life) and mimics the fetal signal that starts the parturition pathway [15]. In studies examining dexamethasone administration in the late term pregnant mares, has shown that fetal death and dystocia occurs, when administered between days 331 and 347 of gestation [16].…”

Section: Induction Of Parturitionmentioning

confidence: 99%

Equine Pregnancy Endocrinology

Trundell¹

2023

Equine Science - Applications and Implications of New Technologies [Working Title]

View full text Add to dashboard Cite

This chapter will review the physiology of the mare pregnancy, which hormones can be evaluated to diagnosis pregnancy, which hormones can be administered parentally to aid establishment of the equine pregnancy and to ensure continued viability of the pregnancy. The chapter will also focus on hormones that can be administered in cases where pregnancy needs to be terminated. The chapter will review new studies examining the use of low dose deslorelin in aiding pregnancy establishment, and will review the use of oral vs. injectable progesterone supplimentation for the continued viability of the pregnancy. The chapter will also review the use of prostaglandins and oxytocin adminstration to terminate the pregnancy.

show abstract