Corticosterone-induced attenuation of epididymal sperm fertility in rats

Abd-Aziz, Noorizan; Durairajanayagam, Damayanthi; Chatterjee, A.; Chatterjee, R.

doi:10.1109/chuser.2012.6504299

Cited by 7 publications

(8 citation statements)

References 11 publications

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“…This is in agreement with the work of [3] and [21] who observed a significant increase in malondialdehyde levels in restraint stressed rats when compared to the normal control rats. [22] reported sustained elevation in oxidative stress biomarkers; superoxide dismutase, glutathione peroxidase and catalase levels in repeated restraint rats. The elevated levels of biomarkers of oxidative stress in the restraint stress rats disagrees with the findings of [23] who observed an increased malondialdehyde level but attenuated levels of other antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities in stressed rats.…”

Section: Discussionmentioning

confidence: 96%

Lipid Peroxidation and Some Antioxidant Enzymes Evaluation in Apple Cider Vinegar (ACV) Treated Male and Female Wistar Rats Exposed to Chronic Restraint Stress

Abdulrauf¹,

Dawud²,

Emmanuel³

et al. 2018

AER

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This study was designed to assess the effect to apple cider vinegar (ACV) on oxidative stress biomarkers in male and female Wistar rats exposed to chronic restraint stress. Severe and persistent stress elevates reactive oxygen species (ROS) production by metabolic and physiological processes; causing cellular damage. Thirty (30) Adult Wistar rats of both sexes weighing about 150 -200 g were divided into 3 groups each consisting of a male and female subgroup and given the following treatments once a day for 21 days: Normal control group received 0.5 ml distilled water orally, the restraint stress (RS) group was exposed to chronic restraint stress 6 hours daily while the Apple cider vinegar (ACV)-treated group received 4 ml/kg of apple cider vinegar orally in addition to chronic restraint stress 6 hours daily. The rats were sacrificed after the experimental period and blood was collected via cardiac puncture for assessing oxidative stress biomarkers. ACV (4 ml/kg) treatment decreased lipid peroxidation (MDA) and serum catalase (CAT) activity while upregulating endogenous superoxide dismutase (SOD) activity. The findings of this study show that the female Wistar rats are more predisposed to the antioxidant effect of ACV than the males.

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Section: Discussionmentioning

confidence: 96%

Lipid Peroxidation and Some Antioxidant Enzymes Evaluation in Apple Cider Vinegar (ACV) Treated Male and Female Wistar Rats Exposed to Chronic Restraint Stress

Abdulrauf¹,

Dawud²,

Emmanuel³

et al. 2018

AER

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“…[33] Immature spermatozoa with cytoplasmic residues show increased production of ROS when compared to sperm with normal morphology. [1757]…”

Section: Physiological Role Of Reactive Oxygen Species In Male Fertilitymentioning

confidence: 99%

Role of oxidative stress in male infertility: An updated review

2019

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Current evidence links oxidative stress (OS) to male infertility, reduced sperm motility, sperm DNA damage and increased risk of recurrent abortions and genetic diseases. A review of PubMed, Medline, Google Scholar, and Cochrane review databases of published articles from years 2000–2018 was performed focusing on physiological and pathological consequences of reactive oxygen species (ROS), sperm DNA damage, OS tests, and the association between OS and male infertility, pregnancy and assisted reproductive techniques outcomes. Generation of ROS is essential for reproductive function, but OS is detrimental to fertility, pregnancy, and genetic status of the newborns. Further, there is a lack of consensus on selecting OS test, type, and duration of antioxidants treatment as well as on the target patients group. Developing advanced diagnostic and therapeutic options for OS is essential to improve fertility potential and limit genetic diseases transmitted to offspring.

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“…The pathophysiology by which glucocorticoids provoke testicular dysfunction is inadequately known; however, it has been validated in many reports that oxidative stress induced by glucocorticoids played a crucial role in the pathophysiology of testicular dysfunction (Abd‐Aziz, Chatterjee, Chatterjee, & Durairajanayagam, ; Hasona, Alrashidi, Aldugieman, Alshdokhi, & Ahmed, ). Moreover, polyunsaturated fatty acid content in testes is more, and this makes testis more vulnerable to peroxidation injury (Agarwal, Virk, Ong, & du Plessis, ).…”

Section: Introductionmentioning

confidence: 99%

Grape seed extract attenuates dexamethasone‐induced testicular and thyroid dysfunction in male albino rats

Hasona

2018

Andrologia

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This study scrutinised the ameliorative properties of grape seed extract (GSE) in dexamethasone (DEX)-induced testicular and thyroid dysfunction associated with oxidative stress in male albino rats. Thirty-two healthy adult male albino rats were divided into four groups of eight animals each: normal, DEX control, DEX + GSE (200 mg/kg body weight) group and DEX + GSE (400 mg/kg body weight) group. The body weight gain and testes weight were assessed. Plasma testosterone and thyroid profile were determined. Testicular glucose-6-phosphate dehydrogenase (G-6-PDH), acid phosphatase (ACP), total protein and glutathione (GSH) levels, as well as catalase (CAT) activity also histopathological changes of the testis were evaluated. DEX treatment caused a significant decrease in body weight gain and weight of testes. Significant alterations in enzymatic and nonenzymatic antioxidants were observed. Moreover, a marked reduction in plasma testosterone levels and thyroid profile was observed. The administration of GSE significantly attenuated the deleterious effects of oxidative stress induced by DEX, as well as attenuated DEX-induced testicular and thyroid damage. Furthermore, DEX induced histological alterations in the testis. GSE ameliorated the injurious effects of DEX and improved the histological alterations in the testis.

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Corticosterone-induced attenuation of epididymal sperm fertility in rats

Cited by 7 publications

References 11 publications

Lipid Peroxidation and Some Antioxidant Enzymes Evaluation in Apple Cider Vinegar (ACV) Treated Male and Female Wistar Rats Exposed to Chronic Restraint Stress

Lipid Peroxidation and Some Antioxidant Enzymes Evaluation in Apple Cider Vinegar (ACV) Treated Male and Female Wistar Rats Exposed to Chronic Restraint Stress

Role of oxidative stress in male infertility: An updated review

Grape seed extract attenuates dexamethasone‐induced testicular and thyroid dysfunction in male albino rats

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