Corticostriatal and corticosubthalamic input zones from the presupplementary motor area in the macaque monkey: comparison with the input zones from the supplementary motor area

Inase, Masahiko; Tokuno, Hironobu; Nambu, Atsushi; Akazawa, Toshikazu; Takada, Masahiko

doi:10.1016/s0006-8993(99)01531-0

Cited by 208 publications

(170 citation statements)

References 62 publications

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“…It is suggested that erroneous predictions function as a "teaching signal" for phasic changes in dopaminergic activity (Hollerman and Schultz, 1998;Schultz and Dickinson, 2000;Schultz, 1998). Thereby, dopaminergic projections from the VTA through the ventral striatum and the frontomedian cortex (Williams and Goldman-Rakic, 1998) provide phasic signals to modify and update stimulus-response mappings (Inase et al, 1999). Activations that we found within these areas can be reconciled with the idea of a summative, value-based attitude formation in natural samplings (Betsch et al, 2001).…”

Section: Discussionsupporting

confidence: 52%

Predicting events of varying probability: uncertainty investigated by fMRI

Volz¹,

Schubotz²,

Cramon³

2003

NeuroImage

193

161

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Many everyday life predictions rely on the experience and memory of event frequencies, i.e., natural samplings. We used functional magnetic resonance imaging (fMRI) to investigate the neural substrates of prediction under varying uncertainty based on a natural sampling approach. The study focused particularly on a comparison with other types of externally attributed uncertainty, such as guessing, and on the frontomedian cortex, which is known to be engaged in many types of decisions under uncertainty. On the basis of preceding stimulus cues, participants predicted events that occurred with probabilities ranging from p ϭ 0.6 to p ϭ 1.0. In contrast to certain predictions in a control task, predictions under uncertainty elicited activations within a posterior frontomedian area (mesial BA 8) and within a set of subcortical areas which are known to subserve dopaminergic modulations. The parametric analysis revealed that activation within the mesial BA 8 significantly increased with increasing uncertainty. A comparison with other types of uncertainty indicates that frontomedian correlates of frequency-based prediction appear to be comparable with those induced in long-term stimulus-response adaptation processes such as hypothesis testing, in contrast to those engaged in short-term error processing such as guessing.

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Section: Discussionsupporting

confidence: 52%

Predicting events of varying probability: uncertainty investigated by fMRI

Volz¹,

Schubotz²,

Cramon³

2003

NeuroImage

193

161

View full text Add to dashboard Cite

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“…Matsumoto et al (2004) suggested a possible indirect pathway between the left IFG and left pSTG/MTG via subcortical regions. An anatomical study in primates showed a pre-SMA projection to the head of the caudate [Inase et al, 1999]; this projection may form the pre-SMA-basal ganglia loop used in word generation [Crosson et al, 2003]. Previous studies based on an inherited speech disorder also suggested that an inferior frontal-basal ganglia loop is a critical neural circuit for speech production [Vargha-Khadem et al, 2005].…”

Section: Discussionmentioning

confidence: 98%

Neural correlates of noncanonical syntactic processing revealed by a picture‐sentence matching task

Kinno¹,

Kawamura²,

Shioda³

et al. 2007

Human Brain Mapping

107

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It remains controversial whether the left inferior frontal gyrus subserves syntactic processing or short-term memory demands. Here we devised a novel picture-sentence matching task involving Japanese sentences with different structures to clearly contrast syntactic reanalysis processes. Using event-related functional magnetic resonance imaging (fMRI), activations under three main conditions were directly compared: a canonical/subject-initial active sentence (AS), a noncanonical/subject-initial passive sentence (PS), and a noncanonical/object-initial scrambled sentence (SS). We found that activation in the dorsal region of the left inferior frontal gyrus (dF3t) was enhanced more by the noncanonical processing under the PS and SS conditions than by the canonical processing under the AS condition, and this enhancement was independent of domain-general factors, such as general memory demands and task difficulty. Moreover, the left posterior superior/middle temporal gyrus (pSTG/ MTG) showed more enhanced responses to object-initial sentences under the SS condition than to subject-initial sentences under the AS and PS conditions, which were not significantly affected by task difficulty. Furthermore, activation in the left lateral premotor cortex (LPMC) increased under the AS, PS, and SS conditions, in that order. It is possible that task difficulty affects the left LPMC, but the three distinct activations patterns suggest that these frontal and temporal regions work in concert to process syntactic structures, with their respective contributions dynamically regulated by linguistic requirements. Hum Brain Mapp 29: [1015][1016][1017][1018][1019][1020][1021][1022][1023][1024][1025][1026][1027] 2008. V V C 2007 Wiley-Liss, Inc.

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“…The Nogo action requires a powerful inhibition, which we assigned to the inhibition from the substantia nigra pars reticulata (SNr). The pre-SMA, among other frontal cortical area, is known to project to the subthalamic nucleus (STN) (Inase et al, 1999) which in turn project to the SNr (Kita and Kitai, 1987). Since these connections are excitatory, the output of pre-SMA neurons would lead to an inhibition of saccadic neurons in the superior colliculus.…”

Section: Discussionmentioning

confidence: 99%

“…This might represent the Nogo or inhibitory action of the switch mechanism. The Go action may be accomplished with the signal originating from the pre-SMA going through the caudate nucleus (Inase et al, 1999). Since the caudate nucleus has direct inhibitory connections to the SNr, the net effect of the pre-SMA signal would be facilitatory .…”

Section: Discussionmentioning

confidence: 99%

Brain mechanisms for switching from automatic to controlled eye movements

Hikosaka¹,

Isoda²

2008

Progress in Brain Research

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Human behaviour is mostly composed of habitual actions that require little conscious control. Such actions may become invalid if the environment changes, at which point we need to switch behaviour by overcoming habitual actions that are otherwise triggered automatically. It is unclear how the brain controls this type of behavioural switching. Here we show that the presupplementary motor area (pre-SMA) in the medial frontal cortex has a function in switching from automatic to volitionally controlled action. This was demonstrated using colour-matching saccade tasks performed by rhesus monkeys. We found that a group of pre-SMA neurons was selectively activated when subjects successfully switched from a habitual saccade to a controlled alternative saccade. Electrical stimulation in the pre-SMA replaced automatic incorrect saccades with slower correct saccades. A further test suggested that the pre-SMA enabled switching by first suppressing an automatic unwanted saccade and then boosting a controlled desired saccade. Our data suggest that the pre-SMA resolves response conflict so that the desired action can be selected. Possible neuronal circuits through which the pre-SMA might exert its switching functions will be discussed.

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Corticostriatal and corticosubthalamic input zones from the presupplementary motor area in the macaque monkey: comparison with the input zones from the supplementary motor area

Cited by 208 publications

References 62 publications

Predicting events of varying probability: uncertainty investigated by fMRI

Predicting events of varying probability: uncertainty investigated by fMRI

Neural correlates of noncanonical syntactic processing revealed by a picture‐sentence matching task

Brain mechanisms for switching from automatic to controlled eye movements

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