Corynebacterium godavarianum Jani et al. 2018 and Corynebacterium hadale Wei et al. 2018 are both later heterotypic synonyms of Corynebacterium gottingense Atasayar et al. 2017, proposal of an emended description of Corynebacterium gottingense Atasayar et al. 2017

Bernard, Kathryn; Pacheco, Ana Luisa; Burdz, Tamara; Wiebe, Deborah; Bernier, Anne-Marie

doi:10.1099/ijsem.0.004153

Cited by 12 publications

(4 citation statements)

References 19 publications

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“…Consistent with the recent re-classification of Corynebacterium hadale and Corynebacterium godavarianum as Corynebacterium gottingense ( Bernard et al, 2020 ), all three strains clustered very closely in the phylogenomic tree as did strains of Corynebacterium accolens and Corynebacterium segmentosum ( Sagerfors et al, 2021 ; Figure 2 ). Similarly, independent assemblies of the genomes of the type strains of Corynebacterium imitans , Corynebacterium jeikeium , Corynebacterium minutissimum , Corynebacterium pilosum and Corynebacterium renale were indistinguishable in the core genome tree ( Figure 2 ), demonstrating reproducibility and robustness of the genome sequencing and compilation by different laboratories.…”

Section: Resultssupporting

confidence: 83%

“…One representative each from the two lineages of Corynebacterium ulcerans ( Subedi et al, 2018 ) was included. Type strains of Corynebacterium hadale and Corynebacterium godavarianum , both heterotypic synonyms of Corynebacterium gottingense , were included ( Bernard et al, 2020 ) along with a ‘ Corynebacterium crenatum ’ strain that is considered to be a subspecies of Corynebacterium glutamicum ( Man et al, 2016 ). The genome sequences of the type strains of Corynebacterium accolens and Corynebacterium segmentosum , which were recently found to belong to the same species, were also included ( Sagerfors et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

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Phylogenomic Reappraisal of Fatty Acid Biosynthesis, Mycolic Acid Biosynthesis and Clinical Relevance Among Members of the Genus Corynebacterium

et al. 2021

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The genus Corynebacterium encompasses many species of biotechnological, medical or veterinary significance. An important characteristic of this genus is the presence of mycolic acids in their cell envelopes, which form the basis of a protective outer membrane (mycomembrane). Mycolic acids in the cell envelope of Mycobacterium tuberculosis have been associated with virulence. In this study, we have analysed the genomes of 140 corynebacterial strains, including representatives of 126 different species. More than 50% of these strains were isolated from clinical material from humans or animals, highlighting the true scale of pathogenic potential within the genus. Phylogenomically, these species are very diverse and have been organised into 19 groups and 30 singleton strains. We find that a substantial number of corynebacteria lack FAS-I, i.e., have no capability for de novo fatty acid biosynthesis and must obtain fatty acids from their habitat; this appears to explain the well-known lipophilic phenotype of some species. In most species, key genes associated with the condensation and maturation of mycolic acids are present, consistent with the reports of mycolic acids in their species descriptions. Conversely, species reported to lack mycolic acids lacked these key genes. Interestingly, Corynebacterium ciconiae, which is reported to lack mycolic acids, appears to possess all genes required for mycolic acid biosynthesis. We suggest that although a mycolic acid-based mycomembrane is widely considered to be the target for interventions by the immune system and chemotherapeutics, the structure is not essential in corynebacteria and is not a prerequisite for pathogenicity or colonisation of animal hosts.

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Section: Resultssupporting

confidence: 83%

Section: Methodsmentioning

confidence: 99%

Phylogenomic Reappraisal of Fatty Acid Biosynthesis, Mycolic Acid Biosynthesis and Clinical Relevance Among Members of the Genus Corynebacterium

et al. 2021

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“…The genus Corynebacterium was first described by Lechmann and Neumann in 1896 and later emended by Bernard et al in 2020 [ 2 ]. This genus currently contains 136 validly published and correctly named species [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Wei et al described, in May 2018, Corynebacterium hadale isolated from hadoplegic water of the New Britain Trench [ 7 ]. Heuristically, in 2020, Bernard et al proposed that C. godavarianum and C. hadale were later heterotypic synonyms of C. gottingense based on 16S rRNA gene sequencing of strains with >99% similarity between them by 16s rRNA [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

First Bacteremia Due to Corynebacterium gottingense in an Immunocompromised Child: A Case Report, 16S rDNA-Based Phylogenetic Analyses and Review of the Literature

et al. 2023

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Corynebacterium gottingense is a Gram-positive bacillus that has not been reported as pathogenic in pediatric patients. Herein, a case of catheter-associated bloodstream infection by C. gottingense in a 13-year-old immunocompromised child with febrile neutropenia induced for osteosarcoma is reported. The species was identified by Sanger sequencing of the 16s rRNA sequence of the bacterial strain and was compared phylogenetically with published sequences. As suggested in the literature, the presented strain was multi-susceptible, particularly to amoxicillin. The patient was treated with piperacillin/tazobactam for seven days in the context of a urinary co-infection, resulting in resolution of fever within 48 h and then relaunched with oral amoxicillin for 3 days (for a total of 10 days of antibiotic therapy). Phylogenetic analyses based on 16S rDNA demonstrated the complexity of the genus Corynebacterium spp. but failed to demonstrate a direct benefit in predicting clinical outcome based on this single information.

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Coryneform Gram‐Positive Rods

Mattos‐Guaraldi,

Santos,

Vieira

2023

ClinMicroNow

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This chapter presents Coryneform bacteria comprising aerobically or facultatively anaerobically growing, asporogenous, non‐acid fast Gram‐positive rods with irregular morphology. Establishing the clinical significance of coryneform bacteria can be difficult for caregivers and microbiologists. Corynebacterium spp. form the predominant group and include diphtheria toxin (DT)‐producing Corynebacterium diphtheriae , the causative agent of classic diphtheria, which was once a major cause of illness and death among children. Laboratory procedures for identification of Corynebacterium spp. and other coryneform bacteria include collection and transport of clinical samples, isolation practices, culture conditions, phenotypic and molecular assays, as well as antimicrobial susceptibility testing. Molecular techniques have been increasingly used in microbiology laboratories for the identification of Corynebacterium species and other coryneform bacteria. Detection of antibodies directed against DT is the only established serologic test for coryneform bacteria.

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Corynebacterium godavarianum Jani et al. 2018 and Corynebacterium hadale Wei et al. 2018 are both later heterotypic synonyms of Corynebacterium gottingense Atasayar et al. 2017, proposal of an emended description of Corynebacterium gottingense Atasayar et al. 2017

Abstract: Seven strains of an unidentifiable Corynebacterium species recovered from blood cultures, urine or cerebrospinal fluid over 26 years, closest to but differentiated from Show more

Cited by 12 publications

References 19 publications

Phylogenomic Reappraisal of Fatty Acid Biosynthesis, Mycolic Acid Biosynthesis and Clinical Relevance Among Members of the Genus Corynebacterium

Phylogenomic Reappraisal of Fatty Acid Biosynthesis, Mycolic Acid Biosynthesis and Clinical Relevance Among Members of the Genus Corynebacterium

First Bacteremia Due to Corynebacterium gottingense in an Immunocompromised Child: A Case Report, 16S rDNA-Based Phylogenetic Analyses and Review of the Literature

Coryneform Gram‐Positive Rods

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