Could “calprotectin” and “endocan” serve as “Troponin of Nephrologists”?

Azimi, Arsalan

doi:10.1016/j.mehy.2016.12.008

Cited by 13 publications

(13 citation statements)

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“…Molecular functions of the protein include hepatocyte growth receptor binding and insulin-like growth factor binding, and associated biological functions include angiogenesis and regulation of cell growth ( 49 ). Several studies have demonstrated a link between serum concentrations of ESM1 and hypertension and cardiovascular disease ( 50 ), as well as renal damage ( 51 ), suggesting it may have clinical utility as an inflammatory biomarker ( 50–52 ). This gene has also been linked to obesity ( 53 ) and diabetes through diabetes-mediated endothelial dysfunction ( 54 ) and subclinical atherosclerosis in patients with type 2 diabetes ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of maternal preconceptional and pregnancy micronutrient interventions on children’s DNA methylation: Findings from the EMPHASIS study

Saffari

Shrestha

Issarapu

et al. 2020

The American Journal of Clinical Nutrition

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Background Maternal nutrition in pregnancy has been linked to offspring health in early and later life, with changes to DNA methylation (DNAm) proposed as a mediating mechanism. Objective We investigated intervention-associated DNAm changes in children whose mothers participated in 2 randomized controlled trials of micronutrient supplementation before and during pregnancy, as part of the EMPHASIS (Epigenetic Mechanisms linking Preconceptional nutrition and Health Assessed in India and sub-Saharan Africa) study (ISRCTN14266771). Design We conducted epigenome-wide association studies with blood samples from Indian (n = 698) and Gambian (n = 293) children using the Illumina EPIC array and a targeted study of selected loci not on the array. The Indian micronutrient intervention was food based, whereas the Gambian intervention was a micronutrient tablet. Results We identified 6 differentially methylated CpGs in Gambians [2.5–5.0% reduction in intervention group, all false discovery rate (FDR) <5%], the majority mapping to ESM1, which also represented a strong signal in regional analysis. One CpG passed FDR <5% in the Indian cohort, but overall effect sizes were small (<1%) and did not have the characteristics of a robust signature. We also found strong evidence for enrichment of metastable epialleles among subthreshold signals in the Gambian analysis. This supports the notion that multiple methylation loci are influenced by micronutrient supplementation in the early embryo. Conclusions Maternal preconceptional and pregnancy micronutrient supplementation may alter DNAm in children measured at 7–9 y. Multiple factors, including differences between the nature of the intervention, participants, and settings, are likely to have contributed to the lack of replication in the Indian cohort. Potential links to phenotypic outcomes will be explored in the next stage of the EMPHASIS study.

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Section: Discussionmentioning

confidence: 99%

Effect of maternal preconceptional and pregnancy micronutrient interventions on children’s DNA methylation: Findings from the EMPHASIS study

Saffari

Shrestha

Issarapu

et al. 2020

The American Journal of Clinical Nutrition

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“…It has been also hypothesized that examining serum endocan levels could help differentiating between various pathogenesis of intrinsic AKI [ 6 ]. Following the considerations of Azimi [ 6 ], intrinsic causes of AKI could be divided into two large groups: Tubular and glomeruli/vasculatures injuries. The first group is represented by ischemic/toxic tubular injuries and tubulointerstitial pathologies, whereas the other one by i.e., glomerulonephritis and vasculitis.…”

Section: Endocan In Akimentioning

confidence: 99%

“…The first group is represented by ischemic/toxic tubular injuries and tubulointerstitial pathologies, whereas the other one by i.e., glomerulonephritis and vasculitis. Endocan as a marker of endothelial disfunction, a disfunction that is an important contributor to glomeruli/vasculatures pathologies, and less to tubular and tubulointerstitial diseases of the kidney could serve as a useful tool in diagnostics of these two entities [ 6 ].…”

Section: Endocan In Akimentioning

confidence: 99%

“…Despite these conflicting results, the characteristics of endocan—its extremely low concentrations in physiological conditions, its stability, and its easy and non-invasive detection in body fluids—suggest endocan as a possible biomarker of clinical importance [ 6 , 7 ]. Endocan has already been linked to the occurrence and course of various conditions, including inflammatory diseases, cancer, sepsis, cardiovascular events (CVE) and kidney diseases [ 1 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Endocan in Selected Kidney Diseases

Nalewajska

Gurazda

Marchelek-Myśliwiec

et al. 2020

IJMS

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Endocan, previously referred to as an endothelial-cell-specific molecule-1 (ESM-1) is a member of a proteoglycan family that is secreted by vascular endothelial cells of different organs, mainly lungs and kidneys. It is assumed to participate in endothelial activation and the triggering of inflammatory reactions, especially in microvasculatures. Thanks to its solubility in human fluids, i.e., urine and blood plasma, its stability and its low concentrations in physiological conditions, endocan has been proposed as an easily available, non-invasive biomarker for identifying and predicting the course of many diseases. Recently, endocan has been studied in relation to kidney diseases. In general, endocan levels have been linked to worse clinical outcomes of renal dysfunction; however, results are conflicting and require further evaluation. In this review, authors summarize available knowledge regarding the role of endocan in pathogenesis and progression of selected kidney diseases.

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“…Endocan has been shown to be correlated with the estimated glomerular filtration rate and, as such, may indicate the stage of chronic kidney disease (CKD) [14]. Indeed, it has been hypothesized that endocan could become a useful marker for differentiating acute kidney injury from CKD [15]. To date, endocan has never been tested in cardiac surgery for the early detection of postoperative pulmonary infection, although other biomarkers have been shown to be of interest in this context.…”

Section: Introductionmentioning

confidence: 99%

Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study

Perrotti¹,

Chenevier‐Gobeaux

Ecarnot³

et al. 2017

Cardiorenal Med

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Objectives: This pilot study aimed to evaluate the relevance of endocan plasma levels for predicting pulmonary infection after cardiac surgery in patients with chronic kidney disease (CKD). Methods: Serum collected in a previous prospective cohort study (from 166 patients with preoperative CKD who underwent cardiac surgery) was used. Five patients with postoperative pulmonary infection were compared with 15 randomly selected CKD patients with an uneventful outcome. Blood samples were tested at 4 time points (preoperatively and 6, 12, and 24 h after the end of surgery). Endocan, procalcitonin, and C-reactive protein plasma levels were compared between the two groups. Results: At 6 h, the patients with pulmonary infection had significantly higher levels of endocan than the patients without pulmonary infection (24.2 ± 15.6 vs. 6.4 ± 3.2 ng/mL; p = 0.03). A receiver operating characteristic curve analysis showed 80% sensitivity and 100% specificity for endocan to predict pulmonary infection (area under the curve 0.84), with a cutoff value of 15.9 ng/mL. The time saved by assessment of the endocan dosage compared to a clinical diagnosis of pulmonary infection was 47 h. Conclusion: This pilot study showed that a specific study to assess the link between endocan plasma levels and pulmonary infection after cardiac surgery in CKD patients is of potential utility.

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Could “calprotectin” and “endocan” serve as “Troponin of Nephrologists”?

Cited by 13 publications

References 56 publications

Effect of maternal preconceptional and pregnancy micronutrient interventions on children’s DNA methylation: Findings from the EMPHASIS study

Effect of maternal preconceptional and pregnancy micronutrient interventions on children’s DNA methylation: Findings from the EMPHASIS study

The Role of Endocan in Selected Kidney Diseases

Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study

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