Could Selenium Administration Alleviate the Disturbances of Blood Parameters Caused by Lithium Administration in Rats?

Kiełczykowska, Małgorzata; Kocot, Joanna; Kurzepa, Jacek; Lewandowska, Anna; Żelazowska, Renata; Musik, Irena

doi:10.1007/s12011-014-9952-4

Cited by 19 publications

(21 citation statements)

References 42 publications

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“…Although the majority of the observed changes were insignificant, co-administration of selenium seems to display a tendency to restoration action in the case of parameters slightly altered by lithium alone (GPx after 3 weeks and the other studied parameters after 6 weeks). The obtained results are consistent with those obtained in our previous study in blood (Kiełczykowska et al 2014).…”

Section: Discussionsupporting

confidence: 93%

The Protective Influence of Selenium on Oxidant Disturbances in Brain of Rats Exposed to Lithium

Kiełczykowska¹,

Kocot

Lewandowska³

et al. 2015

Physiol Res

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For more than sixty years lithium carbonate has been used in medicine. However, during its administration different side effects including oxidative stress can occur. Selenium belongs to essential elements possessing antioxidant properties. This study aimed at evaluating if selenium could be used as a protective adjuvant in lithium therapy. The experiment was performed on four groups of Wistar rats: I (control), II (Li), III (Se), IV (Li + Se) treated with saline, lithium carbonate (2.7 mg Li/kg b.w.), sodium selenite (0.5 mg Se/kg b.w.) and lithium carbonate (2.7 mg Li/kg b.w.) + sodium selenite (0.5 mg Se/kg b.w.), respectively. All substances were administered as water solutions by stomach tube for 3 or 6 weeks. Catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as malonyldialdehyde (MDA) were determined in brain homogenates. Lithium slightly enhanced MDA and depressed CATand SOD after 6 weeks as well as GPx after 3 weeks. Selenium co-administration showed tendency to restore the disturbed parameters. Selenium alone and given with lithium significantly increased GPx vs. Li-treated group after 3 weeks. Having regarded the outcomes of this study, the research on application of selenium during lithium treatment seems to be worth continuation.

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Section: Discussionsupporting

confidence: 93%

The Protective Influence of Selenium on Oxidant Disturbances in Brain of Rats Exposed to Lithium

Kiełczykowska¹,

Kocot

Lewandowska³

et al. 2015

Physiol Res

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“…In the present study the total mean of serum urea in different doses of lithium carbonate and L-ascorbic acid showed higher values compared to the control group. The results agreed with Kielczykowska M, et al reported that lithium carbonate and L-ascorbic acid co administration treated rats in the form of water solution by stomach tube for 6 weeks caused the increased serum urea [22]. A similar study done by Omar HE, et al who reported that different doses of lithium carbonate and antioxidants vitamin treated rats showed increase of urea levels in all treated groups [23].…”

Section: Discussionsupporting

confidence: 86%

“…A similar study done by Sharma S, et al reported that lithium therapy treatment in rats caused increased urea [2]. The results also agree Kielczykowska M, et al Modawe reported that lithium carbonate treated rats in the form of water solution by stomach tube for 6 weeks caused the increased serum urea [22]. A similar study conducted by Omar HE, et al reported that different doses of lithium carbonate treated rats showed increase in all groups treated.…”

Section: Discussionsupporting

confidence: 71%

“…Omar HE, et al reported that different doses of lithium carbonate treated rats showed increase of serum creatinine in all groups of the study, their results agreed with groups B and C but disagreed with group D [23]. Kielczykowska M, et al reported that lithium carbonate treated rats in the form of water solution by stomach tube for 6 weeks caused no change in the concentration of the serum creatinine, their results agreed with group D and disagree with group C and B [22]. Also Omar HE, et al reported that the concentration of serum creatinine was significantly increased in oral administration of different doses of lithium treatment in rats [23].…”

Section: Discussionmentioning

confidence: 92%

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Lithium Carbonate Therapy Causes Nephrotoxicity and its Alleviation with Ascorbic Acid in Wistar Albino Rats

Modawe¹

2018

IJBP

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Backgrounds: Lithium carbonate is drug has been used for prolonged treatment of psychiatric disorders. But was known to be accompanied by side effects and highly toxicity especially to renal tissue.Objectives: this study aimed to investigate the influence of lithium carbonate and ascorbic acid on the kidney tissue in Wistar albino rats.Methodology: Ninety rats were used in two experiments. The experiment was performed in three months and blood samples were collected monthly, then specimen of the kidney, was used for histopathological examination. In experiment 1, forty rats were used and divided to four groups, three groups were subjected to different oral doses of drug (9, 17 and 34 mg/kg/BW) daily and the fourth was kept as control group. In experiment 2, fifty rats were used and divided to five groups, ascorbic acid, (7mg/kg BW) as antioxidant was added to the different doses of drug during the experimental period.Results: Urea and creatinine showed significantly (P≤0.005) higher levels in the groups used different doses of the lithium therapy compared to the control group. Only the uric acid showed significantly (P≤0.003) lower level compared to the control group. Tubular necrosis, congestion and infiltration of inflammatory cells were the common pathological lesions observed in the kidney and congestion of capillaries was the common pathological lesion at different doses of lithium carbonate. The serum levels of urea and uric acid were significantly (p≤0.004) increased in all groups of the treated rats compared to the control group. The serum creatinine was significantly (P≤0.000) higher in rats treated with 9mg/kg BW, and ascorbic acid but other groups treated with higher doses and ascorbic acid showed significantly (p≤0.000) lower levels compared to the control group. For histopatholgical changes, when drug was accompanied by Lascorbic acid, the infiltration of inflammatory cells was less in kidney compared to the groups treated with lithium carbonate alone.Modawe GA and ElBagir NM. Lithium Carbonate Therapy Causes Nephrotoxicity and its Alleviation with Ascorbic Acid in Wistar Albino Rats. Int J Biochem Physiol 2018, 3(3): 000129.Copyright© Modawe GA and ElBagir NM.2 Conclusions: The use of L-ascorbic acid alone also reduced infiltration of inflammatory cells. The study recommended that patients on drug should be periodically evaluated for renal dysfunction and also advised to be supplied with ascorbic acid, to reduce the toxicity of lithium therapy. Future studies should investigate the effect of different doses of the ascorbic acid on responses to lithium therapy. Also the effects of other antioxidants on drug responses should be tested.

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“…In the previous part of our research, we found that lithium treatment significantly decreased serum Mg and enhanced serum Ca [23]. In contrast, in the current study, magnesium in organs was not affected by Li treatment, whereas calcium was changed in the studied organs in different ways.…”

Section: Discussioncontrasting

confidence: 81%

The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats

Kiełczykowska

Musik

Kurzepa

et al. 2016

Biol Trace Elem Res

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Lithium is widely used in medicine and the therapy is often long term. Apart from beneficial effects, its application can cause diverse side effects. The current study was performed with the aim of the evaluation of the effect of lithium and/or selenium administration on magnesium, calcium and silicon levels in rats. The study was performed on rats divided into four groups (six animals each): control—received saline, Li—received Li2CO3 (2.7 mg Li/kg b.w.), Se—received Na2SeO3·H2O (0.5 mg Se/kg b.w.), and Li+Se—received simultaneously Li2CO3 and Na2SeO3·H2O (2.7 and 0.5 mg Se/kg b.w.). The administration was performed in form of water solutions by a stomach tube once a day for 6 weeks. In the organs (liver, kidney, brain, spleen, heart, lung and femoral muscle), the concentrations of magnesium, calcium and silicon were determined. Lithium significantly increased Ca in the kidney, brain and spleen. Coadministration of selenium reversed this effect. No changes of magnesium in organs were observed. Silicon was affected only in spleen—an increase vs. control was observed in all studied groups. The beneficial influence of coadministration of selenium in case of calcium lets us suggest that an issue of its possible use as an adjuvant alleviating side effects in lithium-treated subjects is worth being continued.

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Could Selenium Administration Alleviate the Disturbances of Blood Parameters Caused by Lithium Administration in Rats?

Cited by 19 publications

References 42 publications

The Protective Influence of Selenium on Oxidant Disturbances in Brain of Rats Exposed to Lithium

The Protective Influence of Selenium on Oxidant Disturbances in Brain of Rats Exposed to Lithium

Lithium Carbonate Therapy Causes Nephrotoxicity and its Alleviation with Ascorbic Acid in Wistar Albino Rats

The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats

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