Could serum albumin value and thrombocyte/lymphocyte ratio be an important prognostic factor in determining the severity of COVID 19?

Abstract

Background and aim: Creating potential clinical markers for risk assessment in patients with COVID-19 continues to be an area of interest. In this study, we aimed to evaluate whether serum albumin level and thrombocyte/lymphocyte ratio are related to the severity of the disease. Materials and methods:The patients were divided into two groups according to the severity of disease. Demographic data, serum albumin value, lymphocyte count, TLO-1 values (thrombocyte/lymphocyte ratio-1), the highest thrombocyte count during hospitalization, TLO-2 (thrombocyte/lymphocyte ratio-2) values formed by the highest thrombocyte count, were recorded.Results: There was no statistically significant differences (P > 0.05) in terms of sex, thrombocyte count at the time of admission, and highest thrombocyte count during hospital follow-up. There were statistically significant differences in terms of age, comorbidity, lymphocyte value at the time of hospitalization, lymphocyte count during hospital follow-up, TLO 1, TLO 2, and serum albumin values between the groups. The ICU group were found to be older, had higher rates of comorbidity, lower lymphocyte values, higher TLO 1-2, and lower serum albumin levels (P < 0.05). Conclusion:TLO-2 ratio above 260 and lymphocyte level below 1 103 cells/µL, would be a predictor of further intensive care unit need.

C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19

“…It also has to be considered that these initial studies were made in Chinese populations, with an evident limitation considering the potential generalization of the findings. Similar results were obtained in posterior specific studies not only in Chinese [ 17 , 18 ] but also in Caucasian populations [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. The main limitation of these studies was the usual small sample size, as shown in recent meta-analysis, that confirmed the utility of SA as a prognostic marker in hospitalized acute COVID-19, although again indicating a very high heterogeneity of the analyzed literature, as well as small samples [ 26 , 27 ].…”

“…As a consequence, low levels of albumin indicate a weakened general status and diminished host immune response, which is a well-known factor associated with comorbidity [ 12 ]. In accordance with this observation, an increasing number of studies that have specifically examined the potential predictive capacity of SA in COVID-19 have shown this parameter to be a good course indicator in terms of clinical deterioration, need for admission to the ICU, and mortality in patients with low SA values [ 12 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Value of thiol and ischemia modified albumin (IMA) in predicting mortality in serious COVID-19 pneumonia

“…As in COVID-19, in increased inflammation and OS-related pathophysiological processes, albumin is irreversibly oxidized [ 38 , 39 ]. It has been suggested in many studies that, hypoalbuminemia detected on admission could be predictive of the negative outcomes of COVID-19 [ 40 , 41 ]. Ducastel et al.…”

Liver biomarkers for prognosis in COVID-19

“…In fact, SA predicts ICU admission with a HR score of 1.87, 95% CI 1.05-3.32, p = 0.034 18 . A study conducted in 63 COVID-19 patients from Turkey revealed that SA at admission predicts ICU admission with a cutoff point of ≤ 36 g/L, AUC of 0.989 (95% CI 0.924-1.00; p < 0.001), sensitivity of 96.7%, and specificity of 93.9% 19 . On the other hand, a study of 128 COVID-19 patients from Dubai showed that SA failed to predict ICU admission (AUC 0.256, 95% CI 0.146-0.366) 20 .…”

“…Since the coronavirus disease 2019 (COVID- 19) outbreak began in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread worldwide 1 . COVID-19 presentation is heterogeneous and ranges from asymptomatic disease to severe illness characterized by pneumonia, acute respiratory distress syndrome (ARDS), and sepsis that may eventually lead to death 2 .…”