Coumarin Derivatives and Breast-Feeding

Coumarins in Polymers: From Light Harvesting to Photo-Cross-Linkable Tissue Scaffolds

“…[11][12][13][32][33][34][35][36][37][38][39] One example, warfarin, is the most prescribed anticoagulant on the market. [40][41][42] Recent medicinal research has focused on the use of coumarin derivatives as anti-HIV agents. A recent review by Yu and coworkers described the study of over 150 coumarin derivatives and their efficacy in fighting HIV.…”

Practice Bulletin No. 138

“…A value less than 55% should be followed up by assessing free protein S levels. Women using warfarin or unfractionated heparin who are breastfeeding can continue taking these medications (59)(60)(61). In pregnancy, it is unclear what protein S activity value is diagnostic, but free protein S cutoffs of less than 30% and less than 24% may be used in the second and third trimesters, respectively.…”

“…Warfarin, LMWH, and unfractionated heparin do not accumulate in breast milk and do not induce an anticoagulant effect in the infant; therefore, these anticoagulants may be used in women who breastfeed (59)(60)(61). Unfractionated heparin or LMWH can be restarted 4-6 hours after vaginal delivery or 6-12 hours after cesarean delivery.…”

Pregnancy-associated venous thrombosis

“…Treatment is usually commenced two to three days postpartum but beyond that time, warfarin is not associated with a significantly increased risk of obstetric haemorrhage and, in addition, little of the drug is found in breast milk so adverse neonatal effects have not been recorded clinically. 36 Warfarin may be of particular use when prolonged postnatal anticoagulation is planned, for example, when a woman has suffered an acute VTE towards the end of her pregnancy.…”