The article presents the results of an analysis of the impact of the financial and economic sanctions imposed on Russia by the United States, the EU and a group of countries that joined them in March 2014, which, as we know, were constantly extended and supplemented with further restrictive and prohibitive measures. Auto solved two specific research tasks. This is, first, the definition of channels for sanctions to influence the dynamics of Russia’s economic development. Second, the assessment of the time and strength of the negative impact of sanctions on the values of such macroeconomic indicators as: foreign direct investment and investment (FDI) in fixed assets; fixed assets and their commissioning, gross domestic product (GDP) and industrial production; consumer price indices, real monetary income of the population and final consumption. The use of economic and statistical tools made it possible to determine the years of the most severe impact of anti-Russian sanctions on the listed macroeconomic indicators, which in a certain part are also officially approved indicators of the state of economic security of the country. The similarity of channels and results of sanctions, on the one hand, and global financial and economic crises, on the other hand, is also established.